Antibiotic-resistance mutations in penicillin-binding protein 2 from the ceftriaxone-resistant Neisseria gonorrhoeae strain H041 strike a delicate balance between increasing resistance and maintaining transpeptidase activity.

PMID: 412928292025

Key Findings

The study characterizes various mutant forms of the penA gene, which encodes penicillin-binding protein 2 (PBP2), and their impact on resistance to ceftriaxone, cefixime, and penicillin G in Neisseria gonorrhoeae.

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1gene entry

7mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
penA	1	penicillin-binding protein 2 (PBP2)	CeftriaxoneCefiximePenicillin	Neisseria gonorrhoeae	Reslit	-

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
penA	A311V	-	-	Neisseria gonorrhoeae	Ceftriaxone\|Cefixime	Reslit	-
penA	N512Y	-	-	Neisseria gonorrhoeae	Ceftriaxone\|Cefixime	Reslit	-
penA	I312M	-	-	Neisseria gonorrhoeae	Ceftriaxone\|Cefixime	Reslit

Browse Papers

Antibiotic-resistance mutations in penicillin-binding protein 2 from the ceftriaxone-resistant Neisseria gonorrhoeae strain H041 strike a delicate balance between increasing resistance and maintaining transpeptidase activity.

AMR Genes

AMR Mutations