Verapamil Suppresses the Development of Resistance Against Anti-Tuberculosis Drugs in Mycobacteria.

PMID: 413036062025

Key Findings

Verapamil reduces the resistance frequency of antimycobacterial drugs by downregulating efflux pump expression and inducing DNA repair genes, with a specific point mutation (A90V) in gyrA contributing to moxifloxacin resistance.

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1gene entry

1mutation entry

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
efpA	1	efflux pump	Moxifloxacin	Mycobacterium smegmatis	Reslit	-

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
gyrA	A90V	-	-	Mycobacterium smegmatis	Moxifloxacin	Reslit	-

Browse Papers

Verapamil Suppresses the Development of Resistance Against Anti-Tuberculosis Drugs in Mycobacteria.

AMR Genes

AMR Mutations