Transmission of extended spectrum beta-lactamase-producing Escherichia coli and antimicrobial resistance gene flow across One Health compartments in eastern Africa: a whole-genome sequence analysis from a prospective cohort study.

PMID: 413142272026Malawi|Uganda

Key Findings

The study identified bla CTX-M-15, bla CTX-M-27, and bla CTX-M-14 as the most prevalent extended-spectrum beta-lactamase (ESBL) genes in ESBL-producing E. coli isolates from Malawi and Uganda. Additionally, mutations in pmrB (E123D and Y358N) were found to confer resistance to colistin.

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3gene entries

2mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
blaCTX-M	3	beta-lactamase	CefoxitinCefotaximeCeftriaxoneCeftazidimeCefepime	Escherichia coli	Reslit	-

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
pmrB	Y358N	-	-	-	Colistin	Reslit	-
pmrB	E123D	-	-	-	Colistin	Reslit	-

Browse Papers

Transmission of extended spectrum beta-lactamase-producing Escherichia coli and antimicrobial resistance gene flow across One Health compartments in eastern Africa: a whole-genome sequence analysis from a prospective cohort study.

AMR Genes

AMR Mutations