Emergence of mutH (V76G) among longitudinal carbapenem resistant Klebsiella pneumoniae causing long-term colonization and recurrent infection disrupts DNA mismatch repair and results in a hypermutator phenotype.

PMID: 413325542025

Key Findings

The study identifies a hypermutator phenotype in K. pneumoniae due to a V76G substitution in the mutH gene, which disrupts DNA mismatch repair and leads to increased resistance to ceftazidime-avibactam and meropenem-vaborbactam.

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1gene entry

1mutation entry

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
blaKPC	1	Beta-lactamase	CeftazidimeCarbapenem	Klebsiella pneumoniae	Reslit	-

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
mutH	V76G	G227A	disrupts catalysis due to loss of this stabilizing hydrophobic interaction	Klebsiella pneumoniae	Ceftazidime-avibactam\|Meropenem/vaborbactam	Reslit	-

Browse Papers

Emergence of mutH (V76G) among longitudinal carbapenem resistant Klebsiella pneumoniae causing long-term colonization and recurrent infection disrupts DNA mismatch repair and results in a hypermutator phenotype.

AMR Genes

AMR Mutations