Modulators of gene amplification alter evolution of antibiotic resistance in Staphylococcus aureus.

PMID: 414747952025

Key Findings

The study identifies sdrM as a key gene for delafloxacin resistance in Staphylococcus aureus through gene amplification. Mutations increasing sdrM expression reduce the selection for sdrM amplification.

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1gene entry

3mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
sdrM	1	efflux pump	Delafloxacin	Staphylococcus aureus	Reslit	-

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
rexB	E48K	-	-	-	Daptomycin	Reslit	-
recD2	G360A	-	-	-	Daptomycin	Reslit	-
recD2	A227E	-	-	-	Daptomycin	Reslit	-

Browse Papers

Modulators of gene amplification alter evolution of antibiotic resistance in Staphylococcus aureus.

AMR Genes

AMR Mutations