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Dual role of ramR mutation in enhancing immune activation and elevating eravacycline resistance in Klebsiella pneumoniae.

PMID: 416761142024

Key Findings

mutations in ramR lead to upregulation of efflux pumps

0gene entries

3mutation entries

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
ramR	F165L	-	disrupt the binding affinity of RamR to the ramA promoter	Klebsiella pneumoniae	Eravacycline\|Tetracycline\|Tigecycline\|Minocycline\|Levofloxacin\|Ceftazidime\|Cefepime\|Cefoxitin\|Imipenem\|Meropenem\|Piperacillin/tazobactam\|Ceftolozane/tazobactam\|Aztreonam\|Colistin\|Ertapenem\|Ampicillin/sulbactam\|Imipenem/relebactam	Reslit	-
ramR	I141T	-	no significant impact on RamR's function or DNA-binding affinity	Klebsiella pneumoniae	Eravacycline	Reslit	-
ramR	L58P	-	disrupt the binding affinity of RamR to the ramA promoter	Klebsiella pneumoniae	Eravacycline\|Tetracycline\|Tigecycline\|Minocycline\|Levofloxacin\|Ceftazidime\|Cefepime\|Cefoxitin\|Imipenem\|Meropenem\|Piperacillin/tazobactam\|Ceftolozane/tazobactam\|Aztreonam\|Colistin\|Ertapenem\|Ampicillin/sulbactam\|Imipenem/relebactam	Reslit	-