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Genetic evidence for a role of parC mutations in development of high-level fluoroquinolone resistance in Escherichia coli.

PMID: 88492441996

Key Findings

parC mutations contribute to high-level fluoroquinolone resistance in E. coli.

0gene entries

10mutation entries

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
parC	G78D	-	DNA topoisomerase IV subunit A ParC	Escherichia coli	CiprofloxacinQUINOLONE	ReslitReference Gene Catalog	-
gyrA	S83W	-	DNA gyrase subunit A GyrA	Escherichia coli	QUINOLONE	Reference Gene Catalog	-
gyrA	D87G	-	DNA gyrase subunit A GyrA	Escherichia coli	QUINOLONE/TRICLOSAN	Reference Gene Catalog	-
gyrA	D87Y	-	DNA gyrase subunit A GyrA	Escherichia coli	QUINOLONE	Reference Gene Catalog	-
gyrA	S83L	-	DNA gyrase subunit A GyrA	Escherichia coli	QUINOLONE	Reference Gene Catalog	-
parC	S80I	-	DNA topoisomerase IV subunit A ParC	Escherichia coli	QUINOLONE	Reference Gene Catalog	-
parC	S80R	-	DNA topoisomerase IV subunit A ParC	Escherichia coli	QUINOLONE	Reference Gene Catalog	-
parC	E84G	-	DNA topoisomerase IV subunit A ParC	Escherichia coli	QUINOLONE	Reference Gene Catalog	-
parC	E84K	-	DNA topoisomerase IV subunit A ParC	Escherichia coli	QUINOLONE	Reference Gene Catalog	-