A novel, double mutation in DNA gyrase A of Escherichia coli conferring resistance to quinolone antibiotics.

PMID: 89807601997

Key Findings

The presence of Asp82Gly or Gly81Asp alone led to low-level resistance to fluoroquinolones but not to nalidixic acid resistance. When both mutations were present, resistance to both nalidixic acid and fluoroquinolones was expressed.

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0gene entries

5mutation entries

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
gyrA	G81D	-	-	Escherichia coli	Nalidixic acid\|Fluoroquinolones	Reslit	-
gyrA	D82G	-	DNA gyrase subunit A GyrA, Target modification	Escherichia coli	Nalidixic acid\|FluoroquinolonesQUINOLONECiprofloxacin+1 more	ReslitReference Gene CatalogResFinder Database	-

Browse Papers

A novel, double mutation in DNA gyrase A of Escherichia coli conferring resistance to quinolone antibiotics.

AMR Mutations