Properties of IRT-14 (TEM-45), a newly characterized mutant of TEM-type beta-lactamases.

PMID: 90211941997

Key Findings

IRT-14 (TEM-45) is a mutant TEM-type beta-lactamase that confers resistance to broad-spectrum penicillins with reduced sensitivity to beta-lactamase inhibitors. Structural modifications and promoter region mutations contribute to this resistance.

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4gene entries

2mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
blaTEM	2	beta-lactamase	PenicillinTICARCILLINAMOXICILLINTICARCILLIN+CLAVULANIC ACIDAMPICILLIN+CLAVULANIC ACIDAMPICILLINBETA-LACTAMAMOXICILLIN+CLAVULANIC ACIDPIPERACILLIN+TAZOBACTAM+1 more	Escherichia coli	Card DatabaseReference Gene CatalogResFinder DatabaseReslit

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
blaTEM	M69L	-	-	Escherichia coli	Penicillin	Reslit	-
blaTEM	R275Q	-	-	Escherichia coli	Penicillin	Reslit	-

Browse Papers

Properties of IRT-14 (TEM-45), a newly characterized mutant of TEM-type beta-lactamases.

AMR Genes

AMR Mutations