Sequence of the gene encoding a plasmid-mediated cefotaxime-hydrolyzing class A beta-lactamase (CTX-M-4): involvement of serine 237 in cephalosporin hydrolysis.

PMID: 95931621998Russia

Key Findings

The study identified the blaCTX-M-4 gene, a plasmid-mediated class A beta-lactamase that hydrolyzes cefotaxime. A Ser237Ala mutation in CTX-M-4 reduced its hydrolytic activity against cefotaxime and decreased resistance to the antibiotic.

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5gene entries

2mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
blaCTX-M	1	class A beta-lactamase	CefotaximeAZTREONAMTICARCILLINCEPHALOSPORINAMOXICILLINCEFEPIMEAMPICILLINCEFOTAXIMECEFTAZIDIME+2 more	Escherichia coli Salmonella typhimurium Salmonella enterica subsp. enterica serovar Typhimurium	Card DatabaseReference Gene CatalogResFinder Database

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
blaCTX-M-4	S237A	-	reduced slightly the relative hydrolytic activity against cefotaxime and the susceptibility to inhibition by clavulanate	Escherichia coli, Salmonella typhimurium	Cefotaxime\|Cefoxitin	Reslit	-

Browse Papers

Sequence of the gene encoding a plasmid-mediated cefotaxime-hydrolyzing class A beta-lactamase (CTX-M-4): involvement of serine 237 in cephalosporin hydrolysis.

AMR Genes

AMR Mutations