Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
glycosyltransferase
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| R273C | - | Loss of function | Mycobacterium tuberculosis | ethionamide | Reslit | Candidate |
| G299C | - | Loss of function | Mycobacterium tuberculosis | ethionamide | Reslit | Candidate |
| G356D | - | Loss of function | Mycobacterium tuberculosis | ethionamide | Reslit | Candidate |
| E361A | - | Loss of function | Mycobacterium tuberculosis | ethionamide | Reslit | Candidate |
| A187V | - | single resistance variant | Mycobacterium tuberculosis | isoniazidethionamide | Card DatabaseReslit | Confirmed |
| V237L | - | - | - | ethionamide | Reslit | Candidate |
| A422V | - | - | - | ethionamide | Reslit | Candidate |
| Y155S | - | - | Mycobacterium tuberculosis | ethionamide | Reslit | Candidate |
| H178R | - | - | Mycobacterium tuberculosis | ethionamide | Reslit | Candidate |
| V171G | - | - | Mycobacterium tuberculosis | ethionamide | Reslit | Candidate |
| A35V | - | - | Mycobacterium tuberculosis | isoniazid | Reslit | Candidate |
| F355S | - | single resistance variant | Mycobacterium tuberculosis | isoniazidprothionamide | Card Database | Established |
| - | Loss of function | Mycobacterium tuberculosis | ethionamide | Reslit | Candidate |
Mycothiol biosynthesis is essential for ethionamide susceptibility in Mycobacterium tuberculosis.
Research Article
Mutations in the mshA gene, which is involved in mycothiol biosynthesis, confer co-resistance to isoniazid and ethionamide in Mycobacterium tuberculosis.
Resistance to Isoniazid and Ethionamide in Mycobacterium tuberculosis: Genes, Mutations, and Causalities.
Review
The study identifies key genes and mutations involved in resistance to isoniazid (INH) and ethionamide (ETH) in Mycobacterium tuberculosis, highlighting the role of katG, inhA, and ethA in resistance mechanisms.
Investigating resistance in clinical Mycobacterium tuberculosis complex isolates with genomic and phenotypic antimicrobial susceptibility testing: a multicentre observational study.
Research Article
The study identifies various AMR genes and mutations in Mycobacterium tuberculosis complex isolates, including rpoB, fabG1, inhA, ndh, katG, mshA, ahpC, gyrA, gyrB, rrs, eis, embCAB, pncA, and rpsA, which are associated with resistance to rifampicin, isoniazid, fluoroquinolones, aminoglycosides, ethambutol, and pyrazinamide.
The MAGMA pipeline for comprehensive genomic analyses of clinical Mycobacterium tuberculosis samples.
Research Article
The MAGMA pipeline was developed for comprehensive genomic analyses of clinical Mycobacterium tuberculosis samples, demonstrating improved detection of drug resistance variants compared to existing pipelines like MTBseq. It successfully identified various AMR genes and mutations associated with resistance to multiple anti-TB drugs.
Leveraging large-scale Mycobacterium tuberculosis whole genome sequence data to characterise drug-resistant mutations using machine learning and statistical approaches.
Research Article
The study identifies several genes and mutations associated with drug resistance in Mycobacterium tuberculosis, including pncA, ethA, ndh, mshA, embR, rpoB, inhA, gyrA, and Rv0678, along with their respective mutations that confer resistance to pyrazinamide, ethionamide, isoniazid, rifampicin, ethambutol, fluoroquinolones, bedaquiline, and clofazimine.
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