Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
outer membrane porin
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| G141D | - | single resistance variant, outer membrane protein F OmpF | Escherichia coli | Beta-lactamsCEPHALOSPORIN | Card DatabaseReference Gene Catalog | Confirmed |
| G123D | - | - | Escherichia coli | Carbapenem|Cefepime | Reslit | Candidate |
| G120D | - | increased permeation of various substrates, including carbohydrates and antibiotics |
| Escherichia coli |
Tetracycline|Enoxacin |
Reslit |
| Candidate |
| R132D | - | increased permeation of various substrates, including carbohydrates and antibiotics | Escherichia coli | Nalidixic acid|Tetracycline | Reslit | Candidate |
| T71S | - | - | E. coli | Tetracycline | Reslit | Candidate |
| R154A | - | single resistance variant | Escherichia coli | Beta-lactams | Card Database | Established |
| R154D | - | single resistance variant | Escherichia coli | Beta-lactams | Card Database | Established |
| A123V | - | - | - | Ciprofloxacin | Reslit | Candidate |
| L15Ter | - | outer membrane protein F OmpF | Escherichia coli | CARBAPENEM | Reference Gene Catalog | Established |
| Q88Ter | - | outer membrane protein F OmpF | Escherichia coli | CARBAPENEM | Reference Gene Catalog | Established |
| G141E | - | outer membrane protein F OmpF, single resistance variant | Escherichia coli | CEPHALOSPORINBeta-lactams | Card DatabaseReference Gene Catalog | Confirmed |
| - | - | Escherichia coli | Ceftazidime|Ceftriaxone|Cefepime | Reslit | Candidate |
| - | - | E. coli | Ampicillin|Carbenicillin | Reslit | Candidate |
A Protein Important for Antimicrobial Peptide Resistance, YdeI/OmdA, Is in the Periplasm and Interacts with OmpD/NmpC.
The study identifies YdeI/OmdA, OmpD, YgiW, and OmpF as important for resistance to polymyxin B and cathelicidin antimicrobial peptide in Salmonella enterica serovar Typhimurium.
Differential gene expression by RamA in ciprofloxacin-resistant Salmonella Typhimurium.
The study shows that the constitutive expression of ramA leads to increased expression of the multidrug efflux pump AcrAB-TolC and decreased expression of the porin protein OmpF, resulting in a multiple drug resistance phenotype. Disruption of ramA increases susceptibility to over 70 antimicrobials and toxic compounds.
Subminimal inhibitory concentrations of the disinfectant benzalkonium chloride select for a tolerant subpopulation of Escherichia coli with inheritable characteristics.
Exposure to sub-minimal inhibitory concentrations of benzalkonium chloride selects for a tolerant subpopulation of E. coli, involving upregulation of the acrB efflux gene, downregulation of ompF, and a point mutation in rpsA.
Prediction of antibiotic resistance by gene expression profiles.
The study identifies key genes and mutations involved in antibiotic resistance in E. coli, highlighting the role of gene expression changes and specific mutations in conferring resistance to various antibiotics.
Adaptive modulation of antibiotic resistance through intragenomic coevolution.
The study identifies chromosomal mutations in ompF and acrR that contribute to tetracycline resistance in E. coli, along with plasmid mutations in tetA and tetR that reduce the efficacy of the plasmid-encoded tetracycline efflux pump, demonstrating intragenomic coevolution between the chromosome and plasmid.
Contribution to antibiotic resistance in laboratory evolution experiments and in clinical isolates
The study identifies MGEs carrying antibiotic resistance genes such as vanHBX, blaKPC-2, blaKPC-3, and CTX-M-97, highlighting their role in bacterial adaptation and resistance.
TraDIS-Xpress: a high-resolution whole-genome assay identifies novel mechanisms of triclosan action and resistance.
The study identified several genes involved in triclosan resistance, including fabI, acrAB, ompF, marR, soxS, rpoN, pcnB, infB, lon, rbsB, and trkHA. These genes were found to play roles in triclosan sensitivity through various mechanisms such as efflux pumps, porins, and stress response regulation.
High-throughput laboratory evolution reveals evolutionary constraints in Escherichia coli.
The study identifies several genes and mutations that contribute to chemical resistance in E. coli, including mprA, prlF, acrR, ompF, rssB, ycbZ, and yhjE, which are associated with resistance to various antibiotics and other stressors.
Cefmetazole Resistance Mechanism for Escherichia Coli Including ESBL-Producing Strains.
The study identified that decreased expression of porin genes ompF, ompC, and phoE contributes to cefmetazole resistance in E. coli, particularly in ESBL-producing strains. The addition of relebactam suppressed resistance acquisition.
PhoPQ Regulates Quinolone and Cephalosporin Resistance Formation in Salmonella Enteritidis at the Transcriptional Level.
PhoPQ regulates quinolone and cephalosporin resistance in Salmonella Enteritidis by directly targeting the ompF and acnA genes, affecting envelope integrity, osmotic stress response, and redox balance.
Better together-Salmonella biofilm-associated antibiotic resistance.
The study identifies several genes involved in Salmonella biofilm-associated antibiotic resistance, including efflux pumps, porins, and stress response proteins, highlighting their role in multidrug resistance and biofilm formation.
Fosfomycin Uptake in Escherichia coli Is Mediated by the Outer-Membrane Porins OmpF, OmpC, and LamB.
The study identifies OmpF, OmpC, and LamB as critical outer-membrane porins involved in fosfomycin uptake in E. coli, with their deletion leading to increased resistance to fosfomycin.
Whole genome sequence-based molecular characterization of blood isolates of carbapenem-resistant Enterobacter cloacae complex from ICU patients in Kolkata, India, during 2017-2022: emergence of phylogenetically heterogeneous Enterobacter hormaechei subsp. xiangfangensis.
The study identified several carbapenemase and extended-spectrum beta-lactamase genes, including bla NDM-1, bla NDM-4, bla NDM-5, bla NDM-7, bla OXA-181, bla OXA-232, bla KPC-3, bla CTX-M-15, bla SFO-1, bla ACT, and bla CMH-3, in carbapenem-resistant Enterobacter cloacae complex isolates from Kolkata, India. Novel integrons (In180, In4874, In4887, and In4888) were also discovered.
In-host evolution of Yersinia enterocolitica during a chronic human infection.
The study identifies a novel deletion in the DNA gyrase gene gyrA conferring quinolone resistance and a truncation of OmpF in Yersinia enterocolitica isolates, contributing to third-generation cephalosporin resistance.
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