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Browse Mutations ompFR154D

GeneompF

outer membrane porin protein

Protein ChangeR154D

Validation StatusEstablished

Databases

Card Database

Overview

Mechanism: single resistance variant
Resistance To: Beta-lactams
Organisms: Escherichia coli
Papers: 1

Paper Information1

1

Substitutions in the eyelet region disrupt cefepime diffusion through the Escherichia coli OmpF channel.

PMID 10639355 · 2000

Escherichia coli ompF with mutation conferring resistance to beta-lactam antibiotics; CARD accession: CARD:3003390

Mutation Information

Protein Change: R154D
Organisms: Escherichia coli
Confers Resistance To

ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

Beta-lactams

Effect on Function

single resistance variant

Source Database

Card Database

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© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research