Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
penicillin-binding protein
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| N598K | - | - | Staphylococcus aureus | oxacillin | Reslit | Candidate |
| L421P | - | - | Neisseria gonorrhoeae | ceftriaxone | Reslit | Candidate |
| D354A | - | - | Klebsiella pneumoniae | ceftazidime avibactam | Reslit | Candidate |
| F504L | - | lower affinity for ceftriaxone and restrict conformational changes that normally accompany acylation, single resistance variant | Neisseria gonorrhoeae, Neisseria meningitidis | penicillinceftazidimeceftriaxone+1 more | Card DatabaseReslit | Confirmed |
| P551S | - | single resistance variant | Neisseria gonorrhoeae | penicillinceftriaxonecefixime+1 more | Card DatabaseReslit | Confirmed |
| I415F | - | - | Treponema pallidum | penicillin | Reslit | Candidate |
| I415M | - | - | Treponema pallidum | penicillin | Reslit | Candidate |
| G608D | - | - | Burkholderia pseudomallei | beta lactams | Reslit | Candidate |
| V588F | - | - | - | beta lactams | Reslit | Candidate |
| V631F | - | - | - | beta lactams | Reslit | Candidate |
| G593A | - | - | - | beta lactams | Reslit | Candidate |
| G105R | - | - | Salmonella enterica | amoxicillin | Reslit | Candidate |
| S494H | - | single resistance variant | Helicobacter pylori | amoxicillin | Card DatabaseReslit | Confirmed |
| E572G | - | single resistance variant | Helicobacter pylori | amoxicillin | Card DatabaseReslit | Confirmed |
| G631S | - | - | Staphylococcus aureus | ceftaroline | Reslit | Candidate |
| D156N | - | - | Staphylococcus aureus | ceftaroline | Reslit | Candidate |
| G581D | - | - | Staphylococcus aureus | ceftaroline | Reslit | Candidate |
| H541N | - | - | Neisseria gonorrhoeae | ceftriaxone | Reslit | Candidate |
| G545S | - | reduced acylation rates and increased resistance to cephalosporins, lower affinity for ceftriaxone and restrict conformational changes that normally accompany acylation, single resistance variant | Neisseria gonorrhoeae, Neisseria meningitidis | cefiximeceftriaxoneceftazidime+1 more | Card DatabaseReslit | Confirmed |
| P285A | - | - | Staphylococcus aureus | vancomycin | Reslit | Candidate |
| T439V | - | - | Staphylococcus aureus | vancomycin | Reslit | Candidate |
| A420V | - | - | Staphylococcus aureus | vancomycin | Reslit | Candidate |
| A557T | - | - | Staphylococcus aureus | vancomycin | Reslit | Candidate |
| T691A | - | - | Staphylococcus aureus | vancomycin | Reslit | Candidate |
| P825A | - | - | Staphylococcus aureus | vancomycin | Reslit | Candidate |
| T489E | - | - | Staphylococcus aureus | vancomycin | Reslit | Candidate |
| H121R | - | - | Staphylococcus aureus | vancomycin | Reslit | Candidate |
| R262C | - | - | Staphylococcus aureus | vancomycin | Reslit | Candidate |
| A172T | - | - | Staphylococcus aureus | vancomycin | Reslit | Candidate |
| T31M | - | - | Staphylococcus aureus | oxacillincefoxitinpenicillin | Reslit | Candidate |
| D156Y | - | - | Staphylococcus aureus | oxacillincefoxitinpenicillin | Reslit | Candidate |
| G146R | - | - | Staphylococcus aureus | dalbavancinteicoplanin | Reslit | Candidate |
| A606D | - | - | Staphylococcus aureus | cefoxitinpenicillincephalosporins+2 more | Reslit | Candidate |
| F44S | - | - | Staphylococcus aureus | oxacillin | Reslit | Candidate |
| D350A | - | - | Acinetobacter baumannii | carbapenemscephalosporins | Reslit | Candidate |
| D365A | - | - | Acinetobacter baumannii | carbapenemscephalosporins | Reslit | Candidate |
| C384A | - | - | Acinetobacter baumannii | carbapenemscephalosporins | Reslit | Candidate |
| H371A | - | - | Acinetobacter baumannii | carbapenemscephalosporins | Reslit | Candidate |
| A69V | - | - | Helicobacter pylori | amoxicillin | Reslit | Candidate |
| N512Y | - | lower affinity for ceftriaxone and restrict conformational changes that normally accompany acylation, single resistance variant | Neisseria gonorrhoeae, Neisseria meningitidis | ceftazidimeceftriaxonebeta lactams | Card DatabaseReslit | Confirmed |
| A311V | - | lower affinity for ceftriaxone and restrict conformational changes that normally accompany acylation, single resistance variant | Neisseria gonorrhoeae | ceftazidimeceftriaxonebeta lactams | Card DatabaseReslit | Confirmed |
| I312M | - | lower affinity for ceftriaxone and restrict conformational changes that normally accompany acylation, single resistance variant | Neisseria gonorrhoeae, Neisseria meningitidis | ceftazidimeceftriaxonebeta lactams | Card DatabaseReslit | Confirmed |
| V316T | - | lower affinity for ceftriaxone and restrict conformational changes that normally accompany acylation, single resistance variant | Neisseria gonorrhoeae, Neisseria meningitidis | ceftazidimeceftriaxonebeta lactams | Card DatabaseReslit | Confirmed |
| T483S | - | lower affinity for ceftriaxone and restrict conformational changes that normally accompany acylation, single resistance variant | Neisseria gonorrhoeae | ceftazidimeceftriaxonebeta lactams | Card DatabaseReslit | Confirmed |
| A501V | - | single resistance variant | Neisseria gonorrhoeae | ceftriaxonecefiximebeta lactams | Card DatabaseReslit | Confirmed |
| E183A | - | - | Staphylococcus aureus | ceftobiproleceftriaxonecefazolin+2 more | Reslit | Candidate |
| F241R | - | - | Staphylococcus aureus | ceftobiproleceftriaxonecefazolin+2 more | Reslit | Candidate |
| T534A | - | - | - | ceftriaxonecefixime | Reslit | Candidate |
| A501P | - | single resistance variant | Neisseria gonorrhoeae, Neisseria meningitidis | ceftriaxonecefiximebeta lactams | Card DatabaseReslit | Confirmed |
| G542S | - | single resistance variant | Neisseria gonorrhoeae | ceftriaxonecefiximebeta lactams | Card DatabaseReslit | Confirmed |
| A450D | - | reduced affinity for β-lactams | Staphylococcus aureus | oxacillin | Reslit | Candidate |
| S569A | - | Target modification, penicillin-binding protein PBP2 | Staphylococcus aureus | cefoxitincephalosporins | Reference Gene CatalogResFinder Database | Confirmed |
| A541M | - | single resistance variant | Helicobacter pylori | amoxicillin | Card Database | Established |
| I259T | - | single resistance variant | Helicobacter pylori | amoxicillin | Card Database | Established |
| A296V | - | single resistance variant | Helicobacter pylori | amoxicillin | Card Database | Established |
| A510V | - | single resistance variant | Neisseria gonorrhoeae, Neisseria meningitidis | beta lactams | Card Database | Established |
| A516G | - | single resistance variant | Neisseria gonorrhoeae | beta lactams | Card Database | Established |
| P551L | - | single resistance variant | Neisseria gonorrhoeae | beta lactams | Card Database | Established |
| N513Y | - | single resistance variant | Neisseria gonorrhoeae | beta lactams | Card Database | Established |
| V316P | - | single resistance variant | Neisseria gonorrhoeae | beta lactams | Card Database | Established |
| A501T | - | single resistance variant | Neisseria gonorrhoeae | beta lactams | Card Database | Established |
| G482S | - | single resistance variant | Neisseria meningitidis | beta lactams | Card Database | Established |
| A555T | - | - | meropenem | Reslit | Candidate | |
| A285P | - | Staphylococcus aureus | oxacillin | Reslit | Candidate |
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| pbp2 | Reslit | 12 | Carbapenems, Beta lactams, Oxacillin, Cefixime, Ceftriaxone, Amoxicillin, Ceftaroline, Cephalosporins, Penicillin | Acinetobacter baumannii A118, Laribacter hongkongensis, Staphylococcus aureus, Neisseria gonorrhoeae, Helicobacter pylori, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Escherichia coli, Enterobacter spp. +2 more | Argentina, Hong Kong, Japan, Australia, Sweden, France, Spain, Bronx, New York, Europe, Russia +2 more | 2011, 2013, 2015, 2020, 2022, 2024, 2025, 2026 | AEOW00000000 | - |
| pbp | Reslit | 2 | Beta lactams | Arcobacter butzleri 55, Staphylococcus aureus | shellfish | 2019, 2023 | QXMK00000000|QXNB0000000 | - |
| pb | Reslit | 1 | Polymyxin b | Acinetobacter baumannii | - | 2021 | - | - |
Genomic analysis of Acinetobacter baumannii A118 by comparison of optical maps: identification of structures related to its susceptibility phenotype.
Research Article
The study identifies the absence of the AbaR-type resistance island and the tet(A) gene in Acinetobacter baumannii A118, which may explain its susceptibility to various antibiotics. It also characterizes genes such as cat, bla_ADC, bla_OXA-51-like, carO, and pbp2, which are involved in resistance to chloramphenicol, cephalosporins, carbapenems, and other antibiotics.
Virulence determinants, drug resistance and mobile genetic elements of Laribacter hongkongensis: a genome-wide analysis.
Research Article
The study identifies several β-lactam resistance genes, including ampC, lacA, pbp2, pbp3, pbp4a, pbp6a, and pbp7, as well as multidrug efflux pumps such as acrAB-tolC, acrAD-tolC, mdtABC-tolC, emrAB-tolC, mexAB-oprM, and others. Additionally, genes like bacA, ksgA, crcB, and rarD are implicated in resistance to bacitracin, kasugamycin, streptomycin, camphor, and chloramphenicol, respectively.
Exposure of clinical MRSA heterogeneous strains to β-lactams redirects metabolism to optimize energy production through the TCA cycle.
Research Article
The study identifies genes involved in the metabolic adaptation of MRSA strains under β-lactam pressure, highlighting the role of the TCA cycle and specific genes like mecA, citB, citZ, acsA, pbp2, and femA in mediating resistance to oxacillin.
Current and future antimicrobial treatment of gonorrhoea - the rapidly evolving Neisseria gonorrhoeae continues to challenge.
Review
The paper discusses the emergence of ceftriaxone-resistant Neisseria gonorrhoeae strains, highlighting mutations in penA, mtrR, and penB genes that contribute to resistance. These mutations alter penicillin-binding protein 2, increase efflux pump activity, and reduce drug uptake, respectively.
Genomic Characterization of Arcobacter butzleri Isolated From Shellfish: Novel Insight Into Antibiotic Resistance and Virulence Determinants.
Research Article
The study identified several antibiotic resistance genes in Arcobacter butzleri strains isolated from shellfish, including genes conferring resistance to beta-lactams, polymyxin, chloramphenicol, tetracycline, and macrolides.
Helicobacter pylori Infections in the Bronx, New York: Surveying Antibiotic Susceptibility and Strain Lineage by Whole-Genome Sequencing.
Research Article
The study identified various AMR genes and mutations in H. pylori isolates, including 23S rRNA mutations for clarithromycin resistance, gyrA mutations for levofloxacin resistance, pbp1, pbp2, and pbp3 mutations for amoxicillin resistance, rdxA mutations for metronidazole resistance, 16S rRNA mutations for tetracycline resistance, and rpoB mutations for rifampin resistance.
In vitro and in vivo Activity of Combinations of Polymyxin B with Other Antimicrobials Against Carbapenem-Resistant Acinetobacter baumannii.
Research Article
Polymyxin B (PB) showed 100% sensitivity against ten carbapenem-resistant Acinetobacter baumannii (CRAB) strains. PB combined with other antibiotics exhibited synergistic effects, particularly with rifampicin (RIF).
WYBQ-4: a New Bactericidal Agent against Methicillin-Resistant Staphylococcus aureus.
Research Article
WYBQ-4 is a new bactericidal agent with potent activity against methicillin-resistant Staphylococcus aureus (MRSA). It binds to penicillin-binding proteins (PBPs), including PBP1, PBP2, PBP3, PBP4, and PBP2a, and interferes with cell wall synthesis, leading to bacterial cell death.
In Silico Genome-Scale Analysis of Molecular Mechanisms Contributing to the Development of a Persistent Infection with Methicillin-Resistant Staphylococcus aureus (MRSA) ST239.
Research Article
The study identified specific amino acid substitutions in PBP2 and PBP2a that confer resistance to ceftaroline in the MRSA ST239 strain SA943.
Detecting patterns of accessory genome coevolution in Staphylococcus aureus using data from thousands of genomes.
Research Article
The study identifies coevolving genes in Staphylococcus aureus, highlighting interactions among antibiotic resistance genes, mobile genetic elements, and virulence factors. Key findings include the coevolution of beta-lactam resistance genes (blaZ, blaI, blaR1), metal resistance genes (cadA, cadC, copB, mco), and plasmid replication genes (repD, repE, repN, pre).
Potential involvement of beta-lactamase homologous proteins in resistance to beta-lactam antibiotics in gram-negative bacteria of the ESKAPEE group.
Research Article
The study identifies and characterizes beta-lactamase homologous proteins in gram-negative bacteria of the ESKAPEE group, highlighting their potential role in resistance to beta-lactam antibiotics.
Virulence and resistance gene analysis of Rothia nasimurium by whole gene sequencing.
Research Article
The study identified multiple AMR genes in Rothia nasimurium Y1, including vanA, vanC, vanB, vanE, vanD, vanG, vanF, vanM, vanL, vanO, vanN, mtrA, vanRA, arlR, vanRI, vanRB, vanRC, vanRD, vanRF, vanRG, CpxR, kdpE, vanRM, vanRN, baeR, adeR, vanRL, smeR, gyrA, gyrB, parC, Mfd, mfd, PBP2, PBP2x, EF-Tu, dfrE, pncA, tetB(P), tetQ, tet44, tetT, tetW, tetS, tetM, tetO, otr(A), tet36, tet32, clbC, clbB, clbA, cipA, cfrA, cfrC, sul3, ParY, murA, cls, and ileS, which confer resistance to various antibiotics such as glycopeptides, beta-lactams, fluoroquinolones, tetracyclines, sulfonamides, aminoglycosides, lincosamides, phenicols, macrolides, and others.
Virulence and resistance gene analysis of Rothia nasimurium by whole gene sequencing.
Research Article
The study identified multiple AMR genes in Rothia nasimurium Y1, including vanA, vanC, vanB, vanE, vanD, vanG, vanF, vanM, vanL, vanO, vanN, mtrA, vanRA, arlR, vanRI, vanRB, vanRC, vanRD, vanRF, vanRG, CpxR, kdpE, vanRM, vanRN, baeR, adeR, vanRL, smeR, gyrA, gyrB, parC, Mfd, mfd, PBP2, PBP2x, EF-Tu, dfrE, pncA, tetB(P), tetQ, tet44, tetT, tetW, tetS, tetM, tetO, otr(A), tet36, tet32, clbC, clbB, clbA, cipA, cfrA, cfrC, sul3, ParY, murA, cls, and ileS, which confer resistance to various antibiotics such as glycopeptides, beta-lactams, fluoroquinolones, tetracyclines, sulfonamides, aminoglycosides, lincosamides, phenicols, macrolides, and others.
Genome analysis of Actinobacillus pleuropneumoniae strain APPFJLYC01 reveals multidrug resistance and high virulence potential.
Research Article
The study identified 10 antibiotic resistance genes in the Actinobacillus pleuropneumoniae strain APPFJLYC01, including genes conferring resistance to multiple antibiotic classes such as β-lactams, tetracyclines, aminoglycosides, and macrolides.
Effect of surgical antimicrobial prophylaxis duration for colic surgery on complications and resistome.
Research Article
The study found that extending surgical antimicrobial prophylaxis beyond 24 hours did not increase postoperative complications but led to a higher abundance of beta-lactam resistance genes, including TEM, BlaZ, SHV, CfxA, and PBP2, as well as aminoglycoside-modifying enzymes like AAC(6'), ANT(3"), ANT(6), APH(2"), APH(3'), APH(3"), and APH(6) in the fecal resistome of horses.
No comments yet. Be the first to comment!