ResLit - Antimicrobial Resistance Gene & Mutation Database

Genepbp2

penicillin-binding protein 2

Protein ChangeA450D

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: reduced affinity for β-lactams
Resistance To: Oxacillin
Organisms: Staphylococcus aureus
Papers: 1

Paper Information1

Genetic and Phenotypic Changes Related to the Development of mec-Independent Oxacillin Non-Susceptibility in ST8 Staphylococcus aureus Recovered after Antibiotic Therapy in a Patient with Bacteremia.

PMID 38927220 · 2024

The Ala450Asp mutation in PBP2 contributes to oxacillin resistance.

Mutation Information

pbp2: p.A450D

Protein Change: A450D
Organisms: Staphylococcus aureus
Confers Resistance To

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Mutation Information