Browse AMR Mutations
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
Overview
Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes clinical isolates with alterations in GyrA and ParC proteins.
mutations in gyrA are associated with fluoroquinolone resistance
Molecular Surveillance Identifies Multiple Transmissions of Typhoid in West Africa.
Fluoroquinolone-resistant typhoid, South Africa.
In vitro synergism of ciprofloxacin and cefotaxime against nalidixic acid-resistant Salmonella enterica serotypes Paratyphi A and Paratyphi B.
Ciprofloxacin-resistant Salmonella enterica Serotype Typhi, United States, 1999-2008.
The Evolution of Fluoroquinolone Resistance in Salmonella under Exposure to Sub-Inhibitory Concentration of Enrofloxacin.
mutations in QRDR region
Mutational Diversity in the Quinolone Resistance-Determining Regions of Type-II Topoisomerases of Salmonella Serovars.
Common mutation in S. Typhi and other Salmonella serovars.
Mutations in gyrA are common in quinolone-resistant Salmonella isolates.
Diversity in the Characteristics of Klebsiella pneumoniae ST101 of Human, Environmental, and Animal Origin.
Molecular mechanisms impact on fluoroquinolone resistance among E.coli from enteric carriage monitoring before prostate biopsy and earliest description of qnrB81.
Mutations in the QRDR of gyrA contribute to fluoroquinolone resistance.
Genotypic Diversity among Salmonella Typhi Isolated from Children Living in Informal Settlements in Nairobi, Kenya.
Detection of antimicrobial resistance in Glaesserella parasuis in South China using whole-genome sequencing.
Molecular epidemiology of Salmonella Enteritidis in humans and animals in Spain.
A global atlas and drivers of antimicrobial resistance in Salmonella during 1900-2023.
Unveiling the Genetic Diversity and Antimicrobial Resistance Profiles of Salmonella Population From 2016 to 2020 in Thai Canal Water.
Double amino acid substitutions in both positions of GyrA (S83F, D87N) and ParC (T57S, S80I) were observed in only S. Kentucky ST198 strains.
Detection of Decreased Fluoroquinolone Susceptibility in Salmonellas and Validation of Nalidixic Acid Screening Test
Use of a LightCycler gyrA mutation assay for rapid identification of mutations conferring decreased susceptibility to ciprofloxacin in multiresistant Salmonella enterica serotype Typhimurium DT104 isolates.
Mutations in gyrA confer decreased susceptibility to ciprofloxacin in multiresistant Salmonella enterica serotype Typhimurium DT104 isolates.
Patterns of resistance associated with integrons, the extended-spectrum beta-lactamase SHV-5 gene, and a multidrug efflux pump of Klebsiella pneumoniae causing a nosocomial outbreak.
Increase in nalidixic acid resistance among non-Typhi Salmonella enterica isolates in the United States from 1996 to 2003.
Mutations in gyrA were found in all ciprofloxacin-resistant isolates.
Specific patterns of gyrA mutations determine the resistance difference to ciprofloxacin and levofloxacin in Klebsiella pneumoniae and Escherichia coli.
Mutations in gyrA are responsible for fluoroquinolone resistance.
Multidrug Resistant Klebsiella pneumoniae ST101 Clone Survival Chain From Inpatients to Hospital Effluent After Chlorine Treatment.
amino acid substitutions in GyrA
Escherichia coli Isolated from Diabetic Foot Osteomyelitis: Clonal Diversity, Resistance Profile, Virulence Potential, and Genome Adaptation.
The genomic epidemiology of multi-drug resistant invasive non-typhoidal Salmonella in selected sub-Saharan African countries.
Mutations in gyrA confer resistance to fluoroquinolones.
Genomic evolution of the globally disseminated multidrug-resistant Klebsiella pneumoniae clonal group 147.
Mutation in gyrA leads to decreased susceptibility to fluoroquinolones.
Genetic and in-silico approaches for investigating the mechanisms of ciprofloxacin resistance in Salmonella typhi: Mutations, extrusion, and antimicrobial resistance.
Retrospective analysis of antimicrobial resistance associated with bovine respiratory disease.
Molecular Characteristics of Epidemiologically Successful Salmonella Enteritidis in Poland.
Genomic epidemiology of Salmonella Typhimurium and its monophasic variants in Southern China: A spatiotemporal and source attribution analysis.
Detection and Preliminary Genomic Characterization of Poultry-Derived Salmonella enterica from Southern Kazakhstan.
Ciprofloxacin-resistant Salmonella enterica serovar Typhimurium strains are difficult to select in the absence of AcrB and TolC.
Contribution of target alteration, protection and efflux pump in achieving high ciprofloxacin resistance in Enterobacteriaceae.
Mutations in gyrA gene were identified in several Enterobacteriaceae isolates.
Genomic analysis of Salmonella enterica serotype Paratyphi A during an outbreak in Cambodia, 2013-2015.
Mutation associated with decreased susceptibility to ciprofloxacin.
Whole-Genome Sequencing of Drug-Resistant Salmonella enterica Isolates from Dairy Cattle and Humans in New York and Washington States Reveals Source and Geographic Associations.
Mutations in gyrA are associated with quinolone resistance.
Clinical and molecular characteristics of Chryseobacterium indologenes isolates at a teaching hospital in Shanghai, China.
Mutations in GyrA contribute to quinolone resistance.
Characterisation of Salmonella Enteritidis ST11 and ST1925 Associated with Human Intestinal and Extra-Intestinal Infections in Singapore.
Genomic Epidemiology and Antimicrobial Resistance Mechanisms of Imported Typhoid in Australia.
Extensive Drug-Resistant Salmonella enterica Isolated From Poultry and Humans: Prevalence and Molecular Determinants Behind the Co-resistance to Ciprofloxacin and Tigecycline.
Mutations in gyrA gene were detected at codon S83 or D87 or both in 89.66% of XDR Salmonella.
Detection of Delafloxacin Resistance Mechanisms in Multidrug-Resistant Klebsiella pneumoniae.
Prevalence and characterization of ciprofloxacin-resistant Salmonella enterica spp. isolated from food animals during 2010-2023 in South Korea.
Comprehensive analysis of extensive drug-resistant Salmonella Typhi in Gujarat region, India: genomic findings and prospective alternative therapy.
mutation in QRDR region
Phenotypic and genetic characterization of antimicrobial resistance in Salmonella enterica serovar Choleraesuis isolates from humans and animals in Spain from 2006 to 2021.
Improving health and productivity in laying hens with the phage cocktail SalmoFree®.
Genomic evolution of Salmonella Dublin in cattle and humans in the United States.
A contemporary genomic snapshot of Salmonella Paratyphi A in Pakistan.
Multiple point mutations in gyrA were identified, contributing to ciprofloxacin resistance.
Genomic signature of multidrug-resistant Salmonella enterica serovar typhi isolates related to a massive outbreak in Zambia between 2010 and 2012.
Identification and characterization of multidrug-resistant Salmonella enterica serotype Albert isolates in the United States.
Structure based in silico analysis of quinolone resistance in clinical isolates of Salmonella Typhi from India.
Mutations in DNA Gyrase alter the characteristics of the binding pocket resulting in the loss of crucial molecular interactions and consequently decrease the binding affinity of fluoroquinolones with the target protein.
Mutations in the QRDR of gyrA are responsible for quinolone resistance in S. Typhi.
Antimicrobial susceptibility of travel-related Salmonella enterica serovar Typhi isolates detected in Switzerland (2002-2013) and molecular characterization of quinolone resistant isolates.
Phylogeographical analysis of the dominant multidrug-resistant H58 clade of Salmonella Typhi identifies inter- and intracontinental transmission events.
Antimicrobial Resistance and Molecular Investigation of H2S-Negative Salmonella enterica subsp. enterica serovar Choleraesuis Isolates in China.
S. Enteritidis and S. Typhimurium Harboring SPI-1 and SPI-2 Are the Predominant Serotypes Associated With Human Salmonellosis in Saudi Arabia.
Analysis of isolates from Bangladesh highlights multiple ways to carry resistance genes in Salmonella Typhi.
Mutations in gyrA are associated with ciprofloxacin resistance.
Genomic Features of High-Priority Salmonella enterica Serovars Circulating in the Food Production Chain, Brazil, 2000-2016.
Informal genomic surveillance of regional distribution of Salmonella Typhi genotypes and antimicrobial resistance via returning travellers.
Mutations in the quinolone resistance determining region (QRDR) of gyrA and parC are associated with reduced susceptibility to fluoroquinolones.
Chromosomal and plasmid-mediated fluoroquinolone resistance in human Salmonella enterica infection in Ghana.
Impact of co-existence of PMQR genes and QRDR mutations on fluoroquinolones resistance in Enterobacteriaceae strains isolated from community and hospital acquired UTIs.
Diversity of Serotype, Genotype, and Antibiotic Susceptibility of Salmonella Prevalent in Pickled Ready-to-Eat Meat.
Mutations in GyrA are associated with fluoroquinolone resistance.
Mutations in GyrA contribute to quinolone resistance.
Genetic Diversity of Salmonella enterica subsp. enterica Serovar Enteritidis from Human and Non-Human Sources in Portugal.
Genomic analysis of Salmonella isolated from canal water in Bangkok, Thailand.
Antimicrobial resistance and population genomics of emerging multidrug-resistant Salmonella 4,[5],12:i:- in Guangdong, China.
The Genetic Landscape of Antimicrobial Resistance Genes in Enterococcus cecorum Broiler Isolates.
Lack of efflux mediated quinolone resistance in Salmonella enterica serovars Typhi and Paratyphi A.
associated with resistance
Molecular analysis of ciprofloxacin resistance mechanisms in Malaysian ESBL-producing Klebsiella pneumoniae isolates and development of mismatch amplification mutation assays (MAMA) for rapid detection of gyrA and parC mutations.
Antimicrobial resistance in Salmonella enterica Serovar Typhi isolates from Bangladesh, Indonesia, Taiwan, and Vietnam.
Mutations in gyrA and parC contribute to quinolone resistance.
Fluoroquinolone resistance in Salmonella: insights by whole-genome sequencing.
chromosomal mutations in gyrA contribute to fluoroquinolone resistance
Contribution of OqxAB Efflux Pump in Selection of Fluoroquinolone-Resistant Klebsiella pneumoniae.
Only one mutation found in K. pneumoniae SE191
The phylogeography and incidence of multi-drug resistant typhoid fever in sub-Saharan Africa.
Mutations in gyrA confer reduced susceptibility to fluoroquinolones.
Salmonella enterica Serovar Typhi in Bangladesh: Exploration of Genomic Diversity and Antimicrobial Resistance.
Mutations in gyrA are associated with ciprofloxacin resistance.
Diversity, Virulence, and Antimicrobial Resistance in Isolates From the Newly Emerging Klebsiella pneumoniae ST101 Lineage.
Molecular and Physiological Characterization of Fluoroquinolone-Highly Resistant Salmonella Enteritidis Strains.
Mutations in gyrA are associated with fluoroquinolone resistance.
Non-typhoidal Salmonella blood stream infection in Kuwait: Clinical and microbiological characteristics.
Mutations in gyrA gene confer resistance to ciprofloxacin.
Genetic Diversity of Salmonella Derby from the Poultry Sector in Europe.
Detected in four poultry-related genomes from strains isolated in Italy.
Clonal Spread of pESI-Positive Multidrug-Resistant ST32 Salmonella enterica Serovar Infantis Isolates among Broilers and Humans in Slovenia.
Emergence of colistin resistance and characterization of antimicrobial resistance and virulence factors of Aeromonas hydrophila, Salmonella spp., and Vibrio cholerae isolated from hybrid red tilapia cage culture.
Mutation in gyrA was identified in ciprofloxacin-resistant Salmonella isolates.
Salmonella Typhi whole genome sequencing in Rwanda shows a diverse historical population with recent introduction of haplotype H58.
S83Y substitution in gyrA gene leads to decreased ciprofloxacin susceptibility
Founding of the culture collection of antibiotic-resistant strains of zoonotic bacteria in the Russian Federation.
Genomic analysis and antimicrobial activity of β-lactam/β-lactamase inhibitors and other agents against KPC-producing Klebsiella pneumoniae clinical isolates from Brazilian hospitals.
Phenotypic and genotypic antimicrobial resistance correlation and plasmid characterization in Salmonella spp. isolates from Italy reveal high heterogeneity among serovars.
Laboratory and molecular surveillance of paediatric typhoidal Salmonella in Nepal: Antimicrobial resistance and implications for vaccine policy.
Mutations in the QRDR of gyrA contribute to fluoroquinolone resistance.
Resistome of carbapenem- and colistin-resistant Klebsiella pneumoniae clinical isolates.
mutations in gyrA
Phylogenetic Analysis Indicates a Longer Term Presence of the Globally Distributed H58 Haplotype of Salmonella Typhi in Southern India.
Population structure and antimicrobial resistance patterns of Salmonella Typhi isolates in urban Dhaka, Bangladesh from 2004 to 2016.
Isolation of Drug-Resistant Gallibacterium anatis from Calves with Unresponsive Bronchopneumonia, Belgium.
Molecular epidemiology of Salmonella Infantis in Europe: insights into the success of the bacterial host and its parasitic pESI-like megaplasmid.
Discovery of seven novel mutations of gyrB, parC and parE in Salmonella Typhi and Paratyphi strains from Jiangsu Province of China.
Mutations in gyrA contribute to quinolone resistance
Genomic profiling of antimicrobial resistance genes in clinical isolates of Salmonella Typhi from patients infected with Typhoid fever in India.
Emergence of Multidrug-Resistant Salmonella enterica Subspecies enterica Serovar Infantis of Multilocus Sequence Type 2283 in German Broiler Farms.
Mutation in gyrA leads to resistance against fluoroquinolones
Whole genome sequencing analyses revealed that Salmonella enterica serovar Dublin strains from Brazil belonged to two predominant clades.
Antimicrobial susceptibility and genomic profiling of Salmonella enterica from bloodstream infections at a tertiary referral hospital in Lusaka, Zambia, 2018-2019.
Spread of Carbapenem-Resistant Klebsiella pneumoniae Clinical Isolates Producing NDM-Type Metallo-β-Lactamase in Myanmar.
Antibiotic resistance and associated resistance determinants in different Salmonella enterica serovars isolated from pigs in Argentina.
Other mutations observed: Ser83Phe, Asp87Gly, and a double mutation Ser83Tyr+Asp72Glu.
Detection of Antimicrobial Resistance Mechanisms in Third-Generation Cephalosporin and Ciprofloxacin Resistant Salmonella Isolates from Livestock Meat and Human Diarrhea Patients
Prevalence and whole-genome sequencing analysis of Salmonella reveal its spread along the duck production chain.
Mutations in gyrA contribute to nalidixic acid resistance in Salmonella typhimurium.
Antimicrobial resistance genes, virulence markers and prophage sequences in Salmonella enterica serovar Enteritidis isolated in Tunisia using whole genome sequencing.
Mutations in gyrA gene confer resistance to nalidixic acid and pefloxacin.
Whole genome sequencing of the multidrug-resistant Chryseobacterium indologenes isolated from a patient in Brazil.
Mutation in gyrA contributes to quinolone resistance.
Molecular characterization of circulating Salmonella Typhi strains in an urban informal settlement in Kenya.
Salmonella Typhi Haplotype 58 (H58) Biofilm Formation and Genetic Variation in Typhoid Fever Patients with Gallstones in an Endemic Setting in Kenya.
A retrospective investigation of the population structure and geospatial distribution of Salmonella Paratyphi A in Kathmandu, Nepal.
Mutations in gyrA were associated with reduced susceptibility to fluoroquinolones.
A multicenter genomic epidemiological investigation in Brazil, Chile, and Mexico reveals the diversity and persistence of Salmonella populations in surface waters.
The origins of haplotype 58 (H58) Salmonella enterica serovar Typhi.
Mutations in the quinolone resistance determining region (QRDR) of gyrA are associated with decreased fluoroquinolone susceptibility.
Investigation of gyrA and parC mutations and the prevalence of plasmid-mediated quinolone resistance genes in Klebsiella pneumoniae clinical isolates.
gyrA mutations associated with fluoroquinolone resistance in eight species of Enterobacteriaceae.
gyrA
Mechanisms of quinolone resistance in Escherichia coli and Salmonella: recent developments.
gyrA
Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.
Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone
Alterations in the GyrA subunit of DNA gyrase and the ParC subunit of DNA topoisomerase IV associated with quinolone resistance in Enterococcus faecalis.
Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone
Comparative studies of mutations in animal isolates and experimental in vitro- and in vivo-selected mutants of Salmonella spp. suggest a counterselection of highly fluoroquinolone-resistant strains in the field.
Salmonella typhimurium gyrA mutations associated with fluoroquinolone resistance.
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