Home Browse Genes Browse Mutations Download Collaborators About

Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research

Home Browse Genes Browse Mutations Download Collaborators About

Browse Mutations rpoBS491F

GenerpoB

Protein ChangeS491F

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: upregulation of a previously uncharacterized operon (prdRAB) that leads to cell membrane remodelling and cross-resistance to daptomycin through reduced binding of the antibiotic, mutated
Resistance To: Daptomycin, Daptomycin|Rifampicin
Organisms: Enterococcus faecium
Papers: 2

Paper Information2

1

Rifaximin prophylaxis causes resistance to the last-resort antibiotic daptomycin.

PMID 39443798 · 2024

Mutations in rpoB lead to daptomycin resistance in VREfm.

Mutation Information

Protein Change: S491F
Organisms: Enterococcus faecium
Confers Resistance To: Daptomycin

ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

Effect on Function

upregulation of a previously uncharacterized operon (prdRAB) that leads to cell membrane remodelling and cross-resistance to daptomycin through reduced binding of the antibiotic

Source Database

Reslit

2

Characterization of a Tigecycline-, Linezolid- and Vancomycin-Resistant Clinical Enteroccoccus faecium Isolate, Carrying vanA and vanB Genes.

PMID 37821741 · 2023

Mutation Information

Protein Change: S491F
Organisms: Enterococcus faecium
Confers Resistance To: Daptomycin|Rifampicin
Effect on Function: mutated
Source Database: Reslit

Comments (0)

No comments yet. Be the first to comment!

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research