Browse AMR Mutations
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
Overview
gyrA and gyrB Mutations Are Implicated in Cross-Resistance to Ciprofloxacin and Moxifloxacin in Clostridium difficile.
Research Article
Clostridioides difficile gyrA conferring resistance to fluoroquinolones; CARD accession: CARD:3003995
gyrA
Fluoroquinolone resistance in Clostridium difficile isolates from a prospective study of C. difficile infections in Europe.
Research Article
Thr82Ile was the most frequent amino acid change identified
Effects of exposure of Clostridium difficile PCR ribotypes 027 and 001 to fluoroquinolones in a human gut model.
Research Article
Mutation present in both parent strains and resistant mutants.
Molecular analysis of the gyrA and gyrB quinolone resistance-determining regions of fluoroquinolone-resistant Clostridium difficile mutants selected in vitro.
Research Article
Clostridium difficile Isolates Resistant to Fluoroquinolones in Italy: Emergence of PCR Ribotype 018
Research Article
Mutation in gyrA confers resistance to fluoroquinolones
Antimicrobial susceptibilities and molecular epidemiology of clinical isolates of Clostridium difficile in taiwan.
Research Article
Characterizations of clinical isolates of clostridium difficile by toxin genotypes and by susceptibility to 12 antimicrobial agents, including fidaxomicin (OPT-80) and rifaximin: a multicenter study in Taiwan.
Research Article
Dissimilar Fitness Associated with Resistance to Fluoroquinolones Influences Clonal Dynamics of Various Multiresistant Bacteria.
Review
This mutation was identified in C. difficile ribotype 027 strains and is associated with a minimal fitness cost.
Comparative Genome Analysis and Global Phylogeny of the Toxin Variant Clostridium difficile PCR Ribotype 017 Reveals the Evolution of Two Independent Sublineages.
Research Article
Predominance of Clostridium difficile Ribotypes 017 and 078 among Toxigenic Clinical Isolates in Southern Taiwan.
Research Article
Mutation in gyrA leads to moxifloxacin resistance.
A Clostridium difficile Lineage Endemic to Costa Rican Hospitals Is Multidrug Resistant by Acquisition of Chromosomal Mutations and Novel Mobile Genetic Elements.
Research Article
fluoroquinolone resistance
Genomic evolution and virulence association of Clostridioides difficile sequence type 37 (ribotype 017) in China.
Research Article
associated with fluoroquinolone resistance
A species-wide genetic atlas of antimicrobial resistance in Clostridioides difficile.
Research Article
Most common substitution in fluoroquinolone resistance
Clostridioides difficile evolution in a tertiary German hospital through a retrospective genomic characterization.
Research Article
Whole-Genome Sequencing Reveals the High Nosocomial Transmission and Antimicrobial Resistance of Clostridioides difficile in a Single Center in China, a Four-Year Retrospective Study.
Research Article
Global evolutionary dynamics and resistome analysis of Clostridioides difficile ribotype 017.
Research Article
Molecular Epidemiology and Antimicrobial Resistance of Clostridioides difficile in Hospitalized Patients From Mexico.
Research Article
Phenotypic and genotypic antimicrobial resistance profiles of clinical Clostridioides difficile isolates collected from private and public health settings in South Africa.
Research Article
Mutation in the DNA gyrase A (gyrA) associated with fluoroquinolone resistance
Emerging Clostridioides difficile strains belonging to PCR ribotype 955 in Serbia are distinct from metronidazole-resistant RT955 outbreak isolates from the UK.
Research Article
Phenotypic and genotypic analysis of Clostridium difficile isolates: a single-center study.
Research Article
Defining the phylogenetics and resistome of the major Clostridioides difficile ribotypes circulating in Australia.
Research Article
most common resistance-conferring mutation
Independent Microevolution Mediated by Mobile Genetic Elements of Individual Clostridium difficile Isolates from Clade 4 Revealed by Whole-Genome Sequencing.
Research Article
A global to local genomics analysis of Clostridioides difficile ST1/RT027 identifies cryptic transmission events in a northern Arizona healthcare network.
Research Article
Mutation in gyrA gene associated with fluoroquinolone resistance
Molecular epidemiology of Clostridioides difficile in companion animals: Genetic overlap with human strains and public health concerns.
Research Article
Confirmed by WGS.
Effects of Omeprazole on Recurrent Clostridioides difficile Infection Caused by ST81 Strains and Their Potential Mechanisms.
Research Article
Intrinsic mutation in all ST81 strains
A genomic survey of Clostridioides difficile isolates from hospitalized patients in Melbourne, Australia.
Research Article
Antimicrobial susceptibility profiles of human and piglet Clostridium difficile PCR-ribotype 078.
Research Article
Molecular epidemiology of Clostridium difficile in two tertiary care hospitals in Shandong Province, China.
Research Article
Clostridium difficile Infections: A Global Overview of Drug Sensitivity and Resistance Mechanisms.
Review
Global Evolution of Pathogenic Bacteria With Extensive Use of Fluoroquinolone Agents.
Research Article
High prevalence of Clostridiodes diffiicle PCR ribotypes 001 and 126 in Iran.
Research Article
Origin, genomic diversity and microevolution of the Clostridium difficile B1/NAP1/RT027/ST01 strain in Costa Rica, Chile, Honduras and Mexico.
Research Article
associated with fluoroquinolone resistance
Toxin profiles and antimicrobial resistance patterns among toxigenic clinical isolates of Clostridioides (Clostridium) difficile.
Research Article
The association of a reduced susceptibility to moxifloxacin in causative Clostridium (Clostridioides) difficile strain with the clinical outcome of patients.
Research Article
Thr82Ile in the GyrA was the most prevalent mutation associated with reduced susceptibility to moxifloxacin.
Reference Susceptibility Testing and Genomic Surveillance of Clostridioides difficile, United States, 2012-17.
Research Article
Acquired immune deficiency syndrome and the developing nervous system.
Review
gyrA
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