ResLit - Antimicrobial Resistance Gene & Mutation Database

Nucleotide ChangeG259A

Validation StatusConfirmed2+ DBs

Databases

Card DatabaseReference Gene CatalogResFinder DatabaseReslit

Overview

Resistance To: fluoroquinolones
Organisms: Salmonella enterica, Escherichia coli
Papers: 2

Paper Information2

A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A.

Research Article

PMID 20511368 · 2010

Mutations in gyrA are associated with decreased fluoroquinolone susceptibility.

Mutation Information

gyrA: c.G259A

Nucleotide Change: G259A
Organisms: Salmonella enterica
Confers Resistance To: fluoroquinolones
Validation Method: multiplex PCR and Luminex xTAG assay
Source Database: Reslit

Pandemic fluoroquinolone resistant Escherichia coli clone ST1193 emerged via simultaneous homologous recombinations in 11 gene loci.

Research Article

PMID 31262826 · 2019

Mutation Information

gyrA: p.D87N / c.G259A

Protein Change: D87N
Nucleotide Change: G259A
Organisms: Escherichia coli
Confers Resistance To: fluoroquinolones
Validation Method: sequence analysis
Source Database: Reslit

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