Browse AMR Mutations
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
Overview
Rapid Detection of Multidrug-Resistant Mycobacterium tuberculosis by Use of Real-Time PCR and High-Resolution Melt Analysis.
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First Evaluation of GenoType MTBDRplus 2.0 Performed Directly on Respiratory Specimens in Central America.
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Analytical and clinical performance characteristics of the Abbott RealTime MTB RIF/INH Resistance, an assay for the detection of rifampicin and isoniazid resistant Mycobacterium tuberculosis in pulmonary specimens.
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Evaluation of genotype MTBDRplus assay for rapid detection of isoniazid and rifampicin resistance in Mycobacterium tuberculosis clinical isolates from Pakistan.
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Emergence and clonal transmission of multi-drug-resistant tuberculosis among patients in Chad.
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Investigation of the Rv3065, Rv2942, Rv1258c, Rv1410c, and Rv2459 efflux pump genes expression among multidrug-resistant Mycobacterium tuberculosis clinical isolates.
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The Regulation of ManLAM-Related Gene Expression in Mycobacterium tuberculosis with Different Drug Resistance Profiles Following Isoniazid Treatment.
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Potential of nanopore sequencing for tuberculosis diagnosis and drug resistance detection.
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Direct detection from sputum for drug-resistant Mycobacterium tuberculosis using a CRISPR-Cas14a-based approach.
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Mutation detected in INH-resistant isolates.
Nanopore-based targeted sequencing (NTS) for drug-resistant tuberculosis: an integrated tool for personalized treatment strategies and guidance for new drug development.
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Promoter mutation
Screening and characterization of mutations in isoniazid-resistant Mycobacterium tuberculosis isolates obtained in Brazil.
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Mutations in the inhA promoter region and structural gene were identified, including I21V and I21T.
GenoType MTBDRplus assay for molecular detection of rifampin and isoniazid resistance in Mycobacterium tuberculosis strains and clinical samples.
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The non-clonality of drug resistance in Beijing-genotype isolates of Mycobacterium tuberculosis from the Western Cape of South Africa.
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Confers isoniazid and ethionamide resistance
Evaluation of microscopic observation drug susceptibility assay for diagnosis of multidrug-resistant tuberculosis in Viet Nam.
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Mutation in inhA promoter region
Assessment of a 96-Well Plate Assay of Quantitative Drug Susceptibility Testing for Mycobacterium Tuberculosis Complex in China.
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Direct Detection of Rifampin and Isoniazid Resistance in Sputum Samples from Tuberculosis Patients by High-Resolution Melt Curve Analysis.
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Isoniazid resistance profile and associated levofloxacin and pyrazinamide resistance in rifampicin resistant and sensitive isolates/from pulmonary and extrapulmonary tuberculosis patients in Pakistan: A laboratory based surveillance study 2015-19.
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associated with isoniazid resistance
Xpert MTB/XDR: a 10-Color Reflex Assay Suitable for Point-of-Care Settings To Detect Isoniazid, Fluoroquinolone, and Second-Line-Injectable-Drug Resistance Directly from Mycobacterium tuberculosis-Positive Sputum.
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Genomic Profiling of Mycobacterium tuberculosis Strains, Myanmar.
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Mycobacterium tuberculosis Lineages Associated with Mutations and Drug Resistance in Isolates from India.
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Prevalence of katG and inhA mutations associated with isoniazid resistance in Mycobacterium tuberculosis clinical isolates in Cameroon.
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Mutations associated with resistance to rifampicin and isoniazid identified in strains of the Mycobacterium tuberculosis complex by GenoType MTBDRplus in Panama, 2015-2021.
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Development of multiplex assay for rapid characterization of Mycobacterium tuberculosis.
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Mutation in inhA promoter region (-15 C->T) leads to isoniazid resistance.
Molecular detection of rifampin and isoniazid resistance to guide chronic TB patient management in Burkina Faso.
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High-resolution melting curve analysis for rapid detection of rifampin and isoniazid resistance in Mycobacterium tuberculosis clinical isolates.
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Mutation in inhA promoter region is associated with isoniazid resistance.
Detection of tuberculosis drug resistance: a comparison by Mycobacterium tuberculosis MLPA assay versus Genotype®MTBDRplus.
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Systematic Review of Mutations Associated with Isoniazid Resistance Points to Continuing Evolution and Subsequent Evasion of Molecular Detection, and Potential for Emergence of Multidrug Resistance in Clinical Strains of Mycobacterium tuberculosis.
Review
Molecular Determinants of Ethionamide Resistance in Clinical Isolates of Mycobacterium tuberculosis.
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High specificity but low sensitivity
Evaluation of the cobas MTB and MTB-RIF/INH assay in clinical samples for the detection of Mycobacterium tuberculosis in respiratory specimens.
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Detected in strain MP 2104
Tuberculous spondylitis in Russia and prominent role of multidrug-resistant clone Mycobacterium tuberculosis Beijing B0/W148.
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Resistance to Isoniazid and Ethionamide in Mycobacterium tuberculosis: Genes, Mutations, and Causalities.
Review
High Prevalence of inhA Promoter Mutations among Patients with Drug-Resistant Tuberculosis in KwaZulu-Natal, South Africa.
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The -15C→T mutation was the most common inhA promoter mutation found in the study.
Detection of multidrug-resistant Mycobacterium tuberculosis strains isolated in Brazil using a multimarker genetic assay for katG and rpoB genes.
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associated with isoniazid resistance
Multi-Fluorescence Real-Time PCR Assay for Detection of RIF and INH Resistance of M. tuberculosis.
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Genetic Diversity and Molecular Epidemiology of Mycobacterium tuberculosis in Roraima State, Brazil.
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Prevalence and genetic profiles of isoniazid resistance in tuberculosis patients: A multicountry analysis of cross-sectional data.
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Development of a multiplex droplet digital PCR method for detection and monitoring of Mycobacterium tuberculosis and drug-resistant tuberculosis.
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Predicting extensively drug-resistant Mycobacterium tuberculosis phenotypes with genetic mutations.
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Evaluation of the AID TB resistance line probe assay for rapid detection of genetic alterations associated with drug resistance in Mycobacterium tuberculosis strains.
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Validating a 14-Drug Microtiter Plate Containing Bedaquiline and Delamanid for Large-Scale Research Susceptibility Testing of Mycobacterium tuberculosis.
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Promoter mutation in inhA gene associated with low-level isoniazid resistance.
Unexpected Genomic and Phenotypic Diversity of Mycobacterium africanum Lineage 5 Affects Drug Resistance, Protein Secretion, and Immunogenicity.
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Transition bias influences the evolution of antibiotic resistance in Mycobacterium tuberculosis.
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mutation in inhA promoter leading to isoniazid resistance
Prevalence and molecular characterization of multidrug-resistant M. tuberculosis in Jiangxi province, China.
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Genomic characterization of MDR/XDR-TB in Kazakhstan by a combination of high-throughput methods predominantly shows the ongoing transmission of L2/Beijing 94-32 central Asian/Russian clusters.
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In silico evaluation of WHO-endorsed molecular methods to detect drug resistant tuberculosis.
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Promoter region mutations in inhA
A rapid, accurate, and low-cost method for detecting Mycobacterium tuberculosis and its drug-resistant genes in pulmonary tuberculosis: Applications of MassARRAY DNA mass spectrometry.
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Consistent with phenotypic results
In vitro modeling of isoniazid resistance mechanisms in Mycobacterium tuberculosis H37Rv.
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Detected in passage 2
Molecular characterization of genetic mutations with fitness loss in pulmonary tuberculosis patients associated with HIV co-infection in Northwest Amhara, Ethiopia.
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Detected in INH-mono-resistant isolates
Tuberculosis-spoligo-rifampin-isoniazid typing: an all-in-one assay technique for surveillance and control of multidrug-resistant tuberculosis on Luminex devices.
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Primary multidrug-resistant Mycobacterium tuberculosis in 2 regions, Eastern Siberia, Russian Federation.
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All inhA mutations were associated with a Ser315Thr mutation in katG except for 1 isolate in which katG did not amplify.
Programmatically selected multidrug-resistant strains drive the emergence of extensively drug-resistant tuberculosis in South Africa.
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High-resolution melting analysis for molecular detection of multidrug resistance tuberculosis in Peruvian isolates.
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Isoniazid resistance levels of Mycobacterium tuberculosis can largely be predicted by high-confidence resistance-conferring mutations.
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Mutations promoted from gene entry 'inhA' (model emitted mutations_found inside genes).
Efflux Activity Differentially Modulates the Levels of Isoniazid and Rifampicin Resistance among Multidrug Resistant and Monoresistant Mycobacterium tuberculosis Strains.
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Molecular Targets Related Drug Resistance Mechanisms in MDR-, XDR-, and TDR-Mycobacterium tuberculosis Strains.
Review
Promoter region mutation at position -15C/T is associated with low-level resistance to INH.
Association Between the Phenotype and Genotype of Isoniazid Resistance Among Mycobacterium tuberculosis Isolates in Thailand.
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Emergence of multidrug-resistant Mycobacterium tuberculosis of the Beijing lineage in Portugal and Guinea-Bissau: a snapshot of moving clones by whole-genome sequencing.
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Present in GC1 isolates.
Xpert Mycobacterium tuberculosis/Rifampicin-Detected Rifampicin Resistance is a Suboptimal Surrogate for Multidrug-resistant Tuberculosis in Eastern Democratic Republic of the Congo: Diagnostic and Clinical Implications.
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Translating drug resistant tuberculosis treatment guidelines to reality in war-torn Kandahar, Afghanistan: A retrospective cohort study.
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Mutations in inhA were identified in 8 (9.9%) of patients.
Whole-genome sequencing of Mycobacterium tuberculosis from Cambodia.
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Associated with isoniazid resistance
The Hidden Epidemic of Isoniazid-Resistant Tuberculosis in South Africa.
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