ResLit - Antimicrobial Resistance Gene & Mutation Database

GenevraS

two-component system sensor histidine kinase

Protein ChangeM192I

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: enhanced catalytic efficiency
Resistance To: vancomycin, daptomycin
Organisms: Staphylococcus aureus
Papers: 2

Paper Information2

Contribution of selected gene mutations to resistance in clinical isolates of vancomycin-intermediate Staphylococcus aureus.

Research Article

PMID 22948864 · 2012

Mutation Information

vraS: p.M192I

Protein Change: M192I
Organisms: Staphylococcus aureus
Confers Resistance To: vancomycin
Validation Method: sequencing
Source Database: Reslit

Staphylococcus aureus sensor histidine kinase VraS mutations linked to antibiotic resistance affect enzymatic catalysis, stability, and substrate interactions.

Research Article

PMID 41453699 · 2026

Mutation Information

vraS: p.M192I

Protein Change: M192I
Organisms: Staphylococcus aureus
Confers Resistance To: vancomycindaptomycin
Effect on Function: enhanced catalytic efficiency
Validation Method: kinetic assays and molecular dynamics simulations
Source Database: Reslit

Comments (0)

No comments yet. Be the first to comment!

Mutation Information

Mutation Information

Browse AMR Mutations

Mutation Information

Mutation Information