Browse AMR Mutations
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
Overview
Clinically relevant mutations that cause derepression of the Neisseria gonorrhoeae MtrC-MtrD-MtrE Efflux pump system confer different levels of antimicrobial resistance and in vivo fitness.
Confers higher in vitro resistance and in vivo fitness compared to other mtrR mutations
mtrR
Neisseria gonorrhoeae mtrR with mutation conferring resistance; CARD accession: CARD:3004851
Neisseria gonorrhoeae Sequence Typing for Antimicrobial Resistance, a Novel Antimicrobial Resistance Multilocus Typing Scheme for Tracking Global Dissemination of N. gonorrhoeae Strains.
mutations in mtrR lead to overexpression of the MtrCDE efflux pump, contributing to resistance against multiple antimicrobials
Susceptibility Trends of Zoliflodacin against Multidrug-Resistant Neisseria gonorrhoeae Clinical Isolates in Nanjing, China, 2014 to 2018.
The Impact of Selected Bacterial Sexually Transmitted Diseases on Pregnancy and Female Fertility.
Structures of Neisseria gonorrhoeae MtrR-operator complexes reveal molecular mechanisms of DNA recognition and antibiotic resistance-conferring clinical mutations.
Mutations in mtrR lead to loss of DNA binding and increased resistance to macrolides and cationic antimicrobial peptides.
Molecular Epidemiology, Antimicrobial Surveillance, and PK/PD Analysis to Guide the Treatment of Neisseria gonorrhoeae Infections.
Mutations in the mtrR gene contribute to azithromycin resistance.
The antimicrobial resistance landscape of Neisseria gonorrhoeae in New Zealand from November 2018 to March 2019 and the role of sexual orientation in transmission.
Differential contribution of PBP occupancy and efflux on the effectiveness of β-lactams at their target site in clinical isolates of Neisseria gonorrhoeae.
Mutations in mtrR are associated with increased resistance to beta-lactams, macrolides, and tetracyclines.
WGS to predict antibiotic MICs for Neisseria gonorrhoeae.
Antimicrobial susceptibility of Neisseria gonorrhoeae isolates from Hefei (2014-2015): genetic characteristics of antimicrobial resistance.
Mutations in mtrR gene are associated with resistance to azithromycin.
Plasmid mediated penicillin and tetracycline resistance among Neisseria gonorrhoeae isolates from Kenya.
Mutations in mtrR are associated with overexpression of the MtrCDE efflux pump, contributing to resistance to penicillin and tetracycline.
Genetic AMR mechanisms: genotypic and phenotypic benchmarks
Mutations in mtrR and its promoter contribute to increased resistance to tetracycline and azithromycin.
First National Genomic Epidemiological Study of Neisseria gonorrhoeae Strains Spreading Across Sweden in 2016.
Genetic identification of mutations and MLST types associated with decreased susceptibility to ceftriaxone in Neisseria gonorrhoeae.
Mutations in MtrR are associated with ceftriaxone resistance.
Antimicrobial susceptibility of Neisseria gonorrhoeae isolates from symptomatic men attending the Nanjing sexually transmitted diseases clinic (2011-2012): genetic characteristics of isolates with reduced sensitivity to ceftriaxone.
Equations To Predict Antimicrobial MICs in Neisseria gonorrhoeae Using Molecular Antimicrobial Resistance Determinants.
Travel-associated lineages and unique endemic antimicrobial-susceptible lineages of Neisseria gonorrhoeae predominate in Western Australia.
Penicillin-Binding Protein Occupancy Dataset for 18 β-Lactams and 4 β-Lactamase Inhibitors in Neisseria gonorrhoeae.
Mutation in mtrR gene affects efflux pump regulation and resistance to multiple antibiotics.
Whole genome analysis and antimicrobial resistance of Neisseria gonorrhoeae isolates from Ghana.
Mutations in mtrR were linked to resistance to beta-lactams and macrolides.
Two cases of extensively drug-resistant (XDR) Neisseria gonorrhoeae infection combining ceftriaxone-resistance and high-level azithromycin resistance, France, November 2022 and May 2023.
Antimicrobial susceptibility and genetic characteristics of Neisseria gonorrhoeae isolates from Vietnam, 2011.
Phylogeny and antimicrobial resistance in Neisseria gonorrhoeae isolates from Rio de Janeiro, Brazil.
Genomic epidemiology and antimicrobial resistance of Neisseria gonorrhoeae in New Zealand.
Genotypic characterization and genome comparison reveal insights into potential vaccine coverage and genealogy of Neisseria meningitidis in military camps in Vietnam.
The A39T mutation in mtrR was observed in NMB_VN2013 and NMB_VN2015, and may contribute to increased antibiotic resistance.
Azithromycin resistant gonococci: a literature review.
mutations in mtrR are associated with azithromycin resistance
Whole-genome sequence analysis of high-level penicillin-resistant strains and antimicrobial susceptibility of Neisseria gonorrhoeae clinical isolates from Thailand.
Mutations in mtrR contribute to azithromycin resistance.
Molecular Mechanisms of Drug Resistance and Epidemiology of Multidrug-Resistant Variants of Neisseria gonorrhoeae.
mutations in mtrR contribute to resistance through overexpression of MtrCDE efflux pump
Emergence of Extensively Drug-Resistant Neisseria gonorrhoeae, France, 2023.
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