ResLit - Antimicrobial Resistance Gene & Mutation Database

GenemtrR

transcriptional repressor

Protein ChangeR44A

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: loss of DNA binding
Resistance To: macrolides
Organisms: Neisseria gonorrhoeae
Papers: 1

Paper Information1

Structures of Neisseria gonorrhoeae MtrR-operator complexes reveal molecular mechanisms of DNA recognition and antibiotic resistance-conferring clinical mutations.

Research Article

PMID 33784401 · 2021

Mutations in mtrR lead to loss of DNA binding and increased resistance to macrolides and cationic antimicrobial peptides.

Mutation Information

mtrR: p.R44A

Protein Change: R44A
Organisms: Neisseria gonorrhoeae
Confers Resistance To: macrolides
Effect on Function: loss of DNA binding
Validation Method: fluorescence polarization-based DNA binding assay
Source Database: Reslit

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