Browse AMR Mutations
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
Overview
The DnaK Chaperone System Buffers the Fitness Cost of Antibiotic Resistance Mutations in Mycobacteria.
Research Article
The inhA S94A mutation is associated with isoniazid resistance and shows no fitness defect in the absence of DnaJ1 or DnaJ2.
Computational modeling and bioinformatic analyses of functional mutations in drug target genes in Mycobacterium tuberculosis.
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Whole-genome sequencing of Mycobacterium tuberculosis for prediction of drug resistance.
Research Article
Mutations in inhA were associated with isoniazid resistance.
Clinical and Mycobacterium tuberculosis strain characteristics of tuberculosis patients with diabetes mellitus in Changping District, Beijing, China.
Research Article
Probing mechanisms of resistance to the tuberculosis drug isoniazid: Conformational changes caused by inhibition of InhA, the enoyl reductase from Mycobacterium tuberculosis.
Research Article
Mutations in the cofactor binding site of InhA reduce NADH affinity but have minimal effect on INH-NAD adduct affinity.
Genotypic characterization of drug resistant Mycobacterium tuberculosis in Quebec, 2002-2012.
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most common mutation
Whole genome analysis of extensively drug resistant Mycobacterium tuberculosis strains in Peru.
Research Article
Mycobacterium tuberculosis Lineages Associated with Mutations and Drug Resistance in Isolates from India.
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Whole genome sequencing analysis of Mycobacterium tuberculosis reveals circulating strain types and drug-resistance mutations in the Philippines.
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Mutations associated with isoniazid resistance.
Clinical characteristics and genomic epidemiological survey of tuberculosis in Wuzhou, China, 2022.
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Effects of mutations in multiple Ethionamide-resistance-associated genes among Mycobacterium tuberculosis clinical isolates from China.
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Most prevalent mutation
Population genetics study of isoniazid resistance mutations and evolution of multidrug-resistant Mycobacterium tuberculosis.
Research Article
Resistance to Isoniazid and Ethionamide in Mycobacterium tuberculosis: Genes, Mutations, and Causalities.
Review
Molecular Dynamics Assisted Mechanistic Study of Isoniazid-Resistance against Mycobacterium tuberculosis InhA.
Research Article
Mutations in InhA reduce NADH binding affinity, leading to isoniazid resistance.
Multidrug-Resistant Tuberculosis Complicated by Nosocomial Infection with Multidrug-Resistant Enterobacteriaceae.
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Ion Channel Blockers as Antimicrobial Agents, Efflux Inhibitors, and Enhancers of Macrophage Killing Activity against Drug Resistant Mycobacterium tuberculosis.
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Mutations in inhA gene contribute to isoniazid resistance.
Retrospective Analysis of Archived Pyrazinamide Resistant Mycobacterium tuberculosis Complex Isolates from Uganda-Evidence of Interspecies Transmission.
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Molecular characterization of multidrug-resistant Mycobacterium tuberculosis (MDR-TB) isolates identifies local transmission of infection in Kuwait, a country with a low incidence of TB and MDR-TB.
Research Article
Metabolic Rewiring of Mycobacterium tuberculosis upon Drug Treatment and Antibiotics Resistance.
Review
Rapid detection of isoniazid resistance in Mycobacterium tuberculosis isolates by use of real-time-PCR-based melting curve analysis.
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Pre-clinical evaluation of quinoxaline-derived chalcones in tuberculosis.
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Mutations in inhA gene were identified in clinical isolates and laboratory strains.
Application of next-generation sequencing to detect variants of drug-resistant Mycobacterium tuberculosis: genotype-phenotype correlation.
Research Article
The pathogenic mechanism of Mycobacterium tuberculosis: implication for new drug development.
Review
S94A mutation disrupts hydrogen-bonding network
Role of the first WHO mutation catalogue in the diagnosis of antibiotic resistance in Mycobacterium tuberculosis in the Valencia Region, Spain: a retrospective genomic analysis.
Research Article
mutations in inhA are associated with isoniazid resistance
Systematic review of allelic exchange experiments aimed at identifying mutations that confer drug resistance in Mycobacterium tuberculosis.
Review
Mutation in inhA confers resistance to isoniazid and ethambutol
Isoniazid resistance levels of Mycobacterium tuberculosis can largely be predicted by high-confidence resistance-conferring mutations.
Research Article
Mutations promoted from gene entry 'inhA' (model emitted mutations_found inside genes).
Examining the role of protein structural dynamics in drug resistance in Mycobacterium tuberculosis.
Research Article
The S94A mutation in InhA reduces the effectiveness of INH-NAD inhibition.
Direct Whole-Genome Sequencing of Sputum Accurately Identifies Drug-Resistant Mycobacterium tuberculosis Faster than MGIT Culture Sequencing.
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Emergence of multidrug-resistant Mycobacterium tuberculosis of the Beijing lineage in Portugal and Guinea-Bissau: a snapshot of moving clones by whole-genome sequencing.
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Present in GC1 isolates.
Translating drug resistant tuberculosis treatment guidelines to reality in war-torn Kandahar, Afghanistan: A retrospective cohort study.
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Mutations in inhA were identified in 8 (9.9%) of patients.
Initial resistance to companion drugs should not be considered an exclusion criterion for the shorter multidrug-resistant tuberculosis treatment regimen.
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Mutations in inhA are associated with isoniazid resistance.
A convolutional neural network highlights mutations relevant to antimicrobial resistance in Mycobacterium tuberculosis.
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Phylogenetic lineages of tuberculosis isolates and their association with patient demographics in Tanzania.
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Evaluation of Whole Genome Sequencing-Based Predictions of Antimicrobial Resistance to TB First Line Agents: A Lesson from 5 Years of Data.
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Molecular investigation of resistance to the antituberculous drug ethionamide in multidrug-resistant clinical isolates of Mycobacterium tuberculosis.
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Tuberculosis drug resistance mutation database.
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Genotypic analysis of genes associated with isoniazid and ethionamide resistance in MDR-TB isolates from Thailand.
Research Article
Genome sequencing of 161 Mycobacterium tuberculosis isolates from China identifies genes and intergenic regions associated with drug resistance.
Research Article
The genetics and biochemistry of isoniazid resistance in mycobacterium tuberculosis.
Review
Mycobacterium tuberculosis inhA mutations conferring resistance to ethionamide; CARD accession: CARD:3004876
Mycobacterium tuberculosis inhA mutations conferring resistance to isoniazid; CARD accession: CARD:3003393
A data compendium associating the genomes of 12,289 Mycobacterium tuberculosis isolates with quantitative resistance phenotypes to 13 antibiotics.
Research Article
Mycobacterium tuberculosis inhA mutations conferring resistance to isoniazid; CARD accession: CARD:3003393
Mechanisms of isoniazid resistance in Mycobacterium tuberculosis: enzymatic characterization of enoyl reductase mutants identified in isoniazid-resistant clinical isolates.
Research Article
Mycobacterium tuberculosis inhA mutations conferring resistance to isoniazid; CARD accession: CARD:3003393
Integrating standardized whole genome sequence analysis with a global Mycobacterium tuberculosis antibiotic resistance knowledgebase.
Research Article
Mycobacterium tuberculosis inhA mutations conferring resistance to isoniazid; CARD accession: CARD:3003393
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