Browse AMR Mutations
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
Overview
Computational modeling and bioinformatic analyses of functional mutations in drug target genes in Mycobacterium tuberculosis.
Research Article
The whole-genome sequencing in predicting Mycobacterium tuberculosis drug susceptibility and resistance in Papua, Indonesia.
Research Article
Screening and characterization of mutations in isoniazid-resistant Mycobacterium tuberculosis isolates obtained in Brazil.
Research Article
Mutations in the inhA promoter region and structural gene were identified, including I21V and I21T.
Molecular dynamics simulation studies of the wild-type, I21V, and I16T mutants of isoniazid-resistant Mycobacterium tuberculosis enoyl reductase (InhA) in complex with NADH: toward the understanding of NADH-InhA different affinities.
Research Article
Mutations in the glycine-rich loop of InhA reduce NADH affinity, contributing to isoniazid resistance.
Probing mechanisms of resistance to the tuberculosis drug isoniazid: Conformational changes caused by inhibition of InhA, the enoyl reductase from Mycobacterium tuberculosis.
Research Article
Mutations in the cofactor binding site of InhA reduce NADH affinity but have minimal effect on INH-NAD adduct affinity.
Genotypic characterization of drug resistant Mycobacterium tuberculosis in Quebec, 2002-2012.
Research Article
most common mutation
Whole genome sequencing analysis of Mycobacterium tuberculosis reveals circulating strain types and drug-resistance mutations in the Philippines.
Research Article
Mutations associated with isoniazid resistance.
Evolution and spread of a highly drug resistant strain of Mycobacterium tuberculosis in Papua New Guinea.
Research Article
associated with Isoniazid resistance
Molecular Dynamics Assisted Mechanistic Study of Isoniazid-Resistance against Mycobacterium tuberculosis InhA.
Research Article
Mutations in InhA reduce NADH binding affinity, leading to isoniazid resistance.
Mycobacterium tuberculosis whole genome sequencing provides insights into the Manila strain and drug-resistance mutations in the Philippines.
Research Article
Confirmed in the study
A complete high-quality MinION nanopore assembly of an extensively drug-resistant Mycobacterium tuberculosis Beijing lineage strain identifies novel variation in repetitive PE/PPE gene regions.
Research Article
Prevalence and genetic basis of first-line drug resistance of Mycobacterium tuberculosis in Ca Mau, Vietnam.
Research Article
Quantitative measurement of antibiotic resistance in Mycobacterium tuberculosis reveals genetic determinants of resistance and susceptibility in a target gene approach.
Research Article
mutations
Multi-clonal evolution of multi-drug-resistant/extensively drug-resistant Mycobacterium tuberculosis in a high-prevalence setting of Papua New Guinea for over three decades.
Research Article
Initial resistance to companion drugs should not be considered an exclusion criterion for the shorter multidrug-resistant tuberculosis treatment regimen.
Research Article
Mutations in inhA are associated with isoniazid resistance.
Evaluation of Whole Genome Sequencing-Based Predictions of Antimicrobial Resistance to TB First Line Agents: A Lesson from 5 Years of Data.
Research Article
Genotypic analysis of genes associated with isoniazid and ethionamide resistance in MDR-TB isolates from Thailand.
Research Article
The genetics and biochemistry of isoniazid resistance in mycobacterium tuberculosis.
Review
Tuberculosis drug resistance mutation database.
Research Article
Integrating standardized whole genome sequence analysis with a global Mycobacterium tuberculosis antibiotic resistance knowledgebase.
Research Article
Mycobacterium tuberculosis inhA mutations conferring resistance to ethionamide; CARD accession: CARD:3004876
Mechanisms of isoniazid resistance in Mycobacterium tuberculosis: enzymatic characterization of enoyl reductase mutants identified in isoniazid-resistant clinical isolates.
Research Article
Mycobacterium tuberculosis inhA mutations conferring resistance to isoniazid; CARD accession: CARD:3003393
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