Browse AMR Mutations
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
Overview
Evaluation of the MTBDRsl test for detection of second-line-drug resistance in Mycobacterium tuberculosis.
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detected by MTBDRsl assay
Emergence and molecular characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates from the Delhi Region in India.
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Previously reported
Structural insights into the quinolone resistance mechanism of Mycobacterium tuberculosis DNA gyrase.
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Mutations in the quinolone resistance-determining regions (QRDR) of GyrA and GyrB.
GenoType MTBDRsl for molecular detection of second-line-drug and ethambutol resistance in Mycobacterium tuberculosis strains and clinical samples.
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Mutations in gyrA were associated with resistance to fluoroquinolones.
Characterization of gyrA and gyrB mutations and fluoroquinolone resistance in Mycobacterium tuberculosis clinical isolates from Hubei Province, China.
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Molecular characterization of multidrug- and extensively drug-resistant Mycobacterium tuberculosis strains in Jiangxi, China.
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Includes the most prevalent mutation in gyrA
Mycobacterium tuberculosis Subculture Results in Loss of Potentially Clinically Relevant Heteroresistance
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Selected for in subculture
Identification of drug resistance mutations among Mycobacterium bovis lineages in the Americas.
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The DnaK Chaperone System Buffers the Fitness Cost of Antibiotic Resistance Mutations in Mycobacteria.
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Fluoroquinolone resistance-conferring mutations in gyrA show no fitness defect in the absence of DnaJ1 or DnaJ2.
Microevolution of Mycobacterium tuberculosis Subpopulations and Heteroresistance in a Patient Receiving 27 Years of Tuberculosis Treatment in Germany.
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Globally diverse Mycobacterium tuberculosis resistance acquisition: a retrospective geographical and temporal analysis of whole genome sequences.
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Computational modeling and bioinformatic analyses of functional mutations in drug target genes in Mycobacterium tuberculosis.
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Prevalence of extensively drug-resistant tuberculosis in a Chinese multidrug-resistant TB cohort after redefinition.
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Whole-genome sequencing of Mycobacterium tuberculosis for prediction of drug resistance.
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Mutations in gyrA were associated with ofloxacin resistance.
Molecular Epidemiology of Mycobacterium tuberculosis Complex Strains in Urban and Slum Settings of Nairobi, Kenya.
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Transmission of multidrug-resistant tuberculosis in Jiangxi, China, and associated risk factors.
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Rifampicin and isoniazid resistance not promote fluoroquinolone resistance in Mycobacterium smegmatis.
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Multi-drug resistance and compensatory mutations in Mycobacterium tuberculosis in Vietnam.
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Nanopore-based targeted sequencing (NTS) for drug-resistant tuberculosis: an integrated tool for personalized treatment strategies and guidance for new drug development.
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Surveillance and analysis of drug resistance and drug resistance levels in multidrug resistant tuberculosis on the tropical islands of China.
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Whole-genome sequencing and machine learning reveal key drivers of delayed sputum conversion in rifampicin-resistant tuberculosis.
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Multiplex PCR amplimer conformation analysis for rapid detection of gyrA mutations in fluoroquinolone-resistant Mycobacterium tuberculosis clinical isolates.
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Evaluation of a new line probe assay for rapid identification of gyrA mutations in Mycobacterium tuberculosis.
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associated with fluoroquinolone resistance
Genetic and phenotypic characterization of drug-resistant Mycobacterium tuberculosis isolates in Hong Kong.
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Detected in multiple isolates
Sequence analyses of just four genes to detect extensively drug-resistant Mycobacterium tuberculosis strains in multidrug-resistant tuberculosis patients undergoing treatment.
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Comparative study on genotypic and phenotypic second-line drug resistance testing of Mycobacterium tuberculosis complex isolates.
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mutations detected in 7 strains
Should moxifloxacin be used for the treatment of extensively drug-resistant tuberculosis? An answer from a murine model.
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Mutations in gyrA were associated with increased MICs for fluoroquinolones.
Rapid diagnosis of extensively drug-resistant tuberculosis by use of a reverse line blot hybridization assay.
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Evaluation of two molecular assays for rapid detection of mycobacterium tuberculosis resistance to fluoroquinolones in high-tuberculosis and -multidrug-resistance Settings.
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Most common mutation in FQ-resistant strains.
Incidence of moxifloxacin resistance in clinical Mycobacterium tuberculosis isolates in Houston, Texas.
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Drug-resistant tuberculosis in Central Mozambique: the role of a rapid genotypic susceptibility testing.
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Assessment of a 96-Well Plate Assay of Quantitative Drug Susceptibility Testing for Mycobacterium Tuberculosis Complex in China.
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Molecular characteristics of ofloxacin mono-resistant Mycobacterium tuberculosis isolates from new and previously treated tuberculosis patients.
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Fluoroquinolone Resistance Mutation Detection Is Equivalent to Culture-Based Drug Sensitivity Testing for Predicting Multidrug-Resistant Tuberculosis Treatment Outcome: A Retrospective Cohort Study.
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Mutations in gyrA and gyrB are associated with fluoroquinolone resistance in Mycobacterium tuberculosis.
Molecular Evaluation of Fluoroquinolone Resistance in Serial Mycobacterium tuberculosis Isolates from Individuals Diagnosed with Multidrug-Resistant Tuberculosis.
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Xpert MTB/XDR: a 10-Color Reflex Assay Suitable for Point-of-Care Settings To Detect Isoniazid, Fluoroquinolone, and Second-Line-Injectable-Drug Resistance Directly from Mycobacterium tuberculosis-Positive Sputum.
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Drug-resistant Mycobacterium tuberculosis and its genotypes isolated from an outbreak in western Thailand.
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Moxifloxacin Activates the SOS Response in Mycobacterium tuberculosis in a Dose- and Time-Dependent Manner.
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The mutation D94G in the gyrA gene confers fluoroquinolone resistance.
Clinical outcomes and molecular characterization of drug-resistant tuberculosis in pre- and extensively drug-resistant disease based on line probe assays.
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Increasing prevalence of resistance to second-line drugs among multidrug-resistant Mycobacterium tuberculosis isolates in Kuwait.
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Whole genome analysis of extensively drug resistant Mycobacterium tuberculosis strains in Peru.
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Screening of Compounds for Anti-tuberculosis Activity, and in vitro and in vivo Evaluation of Potential Candidates.
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The D94G mutation in gyrA was found to be the key role of resistance to orbifloxacin.
Evolution and emergence of multidrug-resistant Mycobacterium tuberculosis in Chisinau, Moldova.
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Multiple gyrA mutations (D94G, D94A, A90V) confer resistance to fluoroquinolones.
Genomic Profiling of Mycobacterium tuberculosis Strains, Myanmar.
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Analysis on Drug-Resistance-Associated Mutations among Multidrug-Resistant Mycobacterium tuberculosis Isolates in China.
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Strong Increase in Moxifloxacin Resistance Rate among Multidrug-Resistant Mycobacterium tuberculosis Isolates in China, 2007 to 2013.
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Most common mutation in 2007 and 2013
A modified decision tree approach to improve the prediction and mutation discovery for drug resistance in Mycobacterium tuberculosis.
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Application of Amplicon-Based Targeted NGS Technology for Diagnosis of Drug-Resistant Tuberculosis Using FFPE Specimens.
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high-confidence mutation
Molecular characterisation of second-line drug resistance among drug resistant tuberculosis patients tested in Uganda: a two and a half-year's review.
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Molecular Epidemiology and Polymorphism Analysis in Drug-Resistant Genes in M. tuberculosis Clinical Isolates from Western and Northern India.
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variable codons
Whole genome sequencing analysis of Mycobacterium tuberculosis reveals circulating strain types and drug-resistance mutations in the Philippines.
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Common mutations underlying fluoroquinolone resistance.
Whole-genome sequencing reveals transmission pattern and drug resistance of Mycobacterium tuberculosis intra- or inter-hosts.
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Genetic diversity and transmission pattern of multidrug-resistant tuberculosis based on whole-genome sequencing in Wuhan, China.
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Genomic characterization of multidrug-resistant tuberculosis in Shanghai, China: antibiotic resistance, virulence and transmission.
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Identification and quantification of gyrA variants in fluoroquinolone-resistant Mycobacterium tuberculosis in a MeltArray reaction.
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All mutations are in the quinolone resistance-determining region (QRDR) of gyrA.
Whole-Genome Sequence-Based Diversity of Mycobacterium tuberculosis Strains Isolated from a Central Western Region of Mexico.
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Genomic characterization of XDR Mycobacterium tuberculosis isolates in Argentina (2006-2015).
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Molecular epidemiology of drug resistance and transmission of Mycobacterium tuberculosis in Meigu County, Sichuan Province, China.
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Novel gyrase mutations in quinolone-resistant and -hypersusceptible clinical isolates of Mycobacterium tuberculosis: functional analysis of mutant enzymes.
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Mutations in gyrA and gyrB were associated with quinolone resistance or hypersusceptibility.
Mycobacterium tuberculosis gyrA conferring resistance to fluoroquinolones; CARD accession: CARD:3003295
Association of mutation patterns in gyrA/B genes and ofloxacin resistance levels in Mycobacterium tuberculosis isolates from East China in 2009.
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The S95T mutation in gyrA was a natural polymorphism and not considered a resistance mechanism.
Performance assessment of the GenoType MTBDRsl test and DNA sequencing for detection of second-line and ethambutol drug resistance among patients infected with multidrug-resistant Mycobacterium tuberculosis.
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Effect of efflux pump inhibitors on drug susceptibility of ofloxacin resistant Mycobacterium tuberculosis isolates.
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Seven isolates showed mutations at codon Asp94Tyr, Asp94Val, Asp94Gly, Gly88Arg, Arg98Leu, and Ser95Thr.
New insights into fluoroquinolone resistance in Mycobacterium tuberculosis: functional genetic analysis of gyrA and gyrB mutations.
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Mutations in gyrA were analyzed for their impact on fluoroquinolone resistance.
FIND Tuberculosis Strain Bank: a Resource for Researchers and Developers Working on Tests To Detect Mycobacterium tuberculosis and Related Drug Resistance.
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Some Synonymous and Nonsynonymous gyrA Mutations in Mycobacterium tuberculosis Lead to Systematic False-Positive Fluoroquinolone Resistance Results with the Hain GenoType MTBDRsl Assays.
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Mutations in gyrA lead to false-positive fluoroquinolone resistance results
Diagnostic Performance of the GenoType MTBDRplus and MTBDRsl Assays to Identify Tuberculosis Drug Resistance in Eastern China.
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Prevalence and Molecular Characterization of Second-Line Drugs Resistance among Multidrug-Resistant Mycobacterium tuberculosis Isolates in Southwest of China.
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Extensively drug resistant tuberculosis in Mali: a case report.
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Correlation of gyr Mutations with the Minimum Inhibitory Concentrations of Fluoroquinolones among Multidrug-Resistant Mycobacterium tuberculosis Isolates in Bangladesh.
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Mutations in the gyrA gene are associated with fluoroquinolone resistance in MDR-TB isolates.
Putative extensive and pre-extensive drug resistant-tuberculosis associated with unusual genotypes on the Thailand-Myanmar border.
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Performance of GenoType MTBDRsl assay for detection of second-line drugs and ethambutol resistance directly from sputum specimens of MDR-TB patients in Bangladesh.
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Epidemiological cut-off values for a 96-well broth microdilution plate for high-throughput research antibiotic susceptibility testing of M. tuberculosis.
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Use of Whole-Genome Sequencing to Predict Mycobacterium tuberculosis Complex Drug Resistance from Early Positive Liquid Cultures.
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Evolution and spread of a highly drug resistant strain of Mycobacterium tuberculosis in Papua New Guinea.
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associated with Fluoroquinolone resistance
Whole genomic analysis uncovers high genetic diversity of rifampicin-resistant Mycobacterium tuberculosis strains in Botswana.
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Evaluation of the Xpert MTB/XDR test for detection of isoniazid, fluoroquinolones, and second-line injectable drugs resistance to Mycobacterium tuberculosis-Anhui Province, China.
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Tracking the evolution of an extensively drug-resistant cross-border Mycobacterium tuberculosis cluster, Europe, January 2016 up to August 2025: implications for European surveillance.
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Fluoroquinolone and Second-Line Injectable Resistance Among Rifampicin- and Isoniazid-Resistant Mycobacterium tuberculosis Clinical Isolates: A Molecular Study from a High-Burden Setting.
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mutations in gyrA are associated with fluoroquinolone resistance
A novel one-tube nested fluorescence melting curve analysis for rapid detection of drug-resistant Mycobacterium tuberculosis.
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All mutations were confirmed by DNA sequencing.
Characterization of extensively drug-resistant Mycobacterium tuberculosis isolates circulating in Siberia.
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associated with ofloxacin resistance
Unraveling Mycobacterium tuberculosis genomic diversity and evolution in Lisbon, Portugal, a highly drug resistant setting.
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Mutations in gyrA are associated with fluoroquinolone resistance.
Correlating Minimum Inhibitory Concentrations of ofloxacin and moxifloxacin with gyrA mutations using the genotype MTBDRsl assay.
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Mutations in gyrA are associated with fluoroquinolone resistance in Mycobacterium tuberculosis.
Molecular diagnosis of fluoroquinolone resistance in Mycobacterium tuberculosis.
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Mutations in gyrA are associated with fluoroquinolone resistance.
Clinical application of whole-genome sequencing to inform treatment for multidrug-resistant tuberculosis cases.
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Whole genome sequencing based characterization of extensively drug-resistant Mycobacterium tuberculosis isolates from Pakistan.
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Mutations in the gyrA gene associated with fluoroquinolone resistance
Frequency and geographic distribution of gyrA and gyrB mutations associated with fluoroquinolone resistance in clinical Mycobacterium tuberculosis isolates: a systematic review.
Review
Mutations in gyrA are associated with fluoroquinolone resistance in Mycobacterium tuberculosis.
Comparative Evaluation of Sloppy Molecular Beacon and Dual-Labeled Probe Melting Temperature Assays to Identify Mutations in Mycobacterium tuberculosis Resulting in Rifampin, Fluoroquinolone and Aminoglycoside Resistance.
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Correlation between GyrA substitutions and ofloxacin, levofloxacin, and moxifloxacin cross-resistance in Mycobacterium tuberculosis.
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Mutations in gyrA QRDR correlate with increased MICs for fluoroquinolones.
Diagnostic Performance of the New Version (v2.0) of GenoType MTBDRsl Assay for Detection of Resistance to Fluoroquinolones and Second-Line Injectables Drugs: a Multicenter Study.
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Determination of MICs of levofloxacin for Mycobacterium tuberculosis with gyrA mutations.
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Mutations in gyrA were correlated with levofloxacin resistance.
Gyrase Mutations Are Associated with Variable Levels of Fluoroquinolone Resistance in Mycobacterium tuberculosis.
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MTBDRplus and MTBDRsl Assays: Absence of Wild-Type Probe Hybridization and Implications for Detection of Drug-Resistant Tuberculosis.
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Fluoroquinolone interactions with Mycobacterium tuberculosis gyrase: Enhancing drug activity against wild-type and resistant gyrase.
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Mutations in GyrA lead to fluoroquinolone resistance by disrupting the water-metal ion bridge.
Mycobacterium tuberculosis whole genome sequencing and protein structure modelling provides insights into anti-tuberculosis drug resistance.
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Moxifloxacin Improves Treatment Outcomes in Patients with Ofloxacin-Resistant Multidrug-Resistant Tuberculosis.
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Mutation at codon 94 in the gyrA gene was the most frequent mutation associated with high-level MFX resistance.
Whole genomic sequencing as a tool for diagnosis of drug and multidrug-resistance tuberculosis in an endemic region in Mexico.
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Development and evaluation of novel bio-safe filter paper-based kits for sputum microscopy and transport to directly detect Mycobacterium tuberculosis and associated drug resistance.
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Fluoroquinolone heteroresistance in Mycobacterium tuberculosis: detection by genotypic and phenotypic assays in experimentally mixed populations.
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wild-type gyrA is susceptible to fluoroquinolones
Prevalence, risk and genetic characteristics of drug-resistant tuberculosis in a tertiary care tuberculosis hospital in China.
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The Genetic Background Modulates the Evolution of Fluoroquinolone-Resistance in Mycobacterium tuberculosis.
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Most prevalent in high-frequency OFX-R strains.
Whole genome sequencing of drug resistant Mycobacterium tuberculosis isolates from a high burden tuberculosis region of North West Pakistan.
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Phenotypic and genotypic characterization of levofloxacin- and moxifloxacin-resistant Mycobacterium tuberculosis clinical isolates in southern China.
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Novel mutations detected in gyrA and gyrB genes.
Molecular characterization of pre-extensive drug resistant Mycobacterium tuberculosis in Northeast Brazil.
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Transmission dynamics of drug-resistant tuberculosis in Ningbo, China: an epidemiological and genomic analysis.
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Mutational Dynamics Related to Antibiotic Resistance in M. tuberculosis Isolates from Serial Samples of Patients with Tuberculosis and Type 2 Diabetes Mellitus.
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observed in one isolate from one individual with T2DM-TB
Rapid detection of multidrug resistance in tuberculosis using nanopore-based targeted next-generation sequencing: a multicenter, double-blind study.
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Common mutation in gyrA
Development of a multiplex droplet digital PCR method for detection and monitoring of Mycobacterium tuberculosis and drug-resistant tuberculosis.
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Whole-genome sequencing of clinical isolates from tuberculosis patients in India: real-world data indicates a high proportion of pre-XDR cases.
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Mutations in gyrA are associated with fluoroquinolone resistance.
Drug Resistance and Epidemiological Success of Modern Mycobacterium tuberculosis Lineages in Western India.
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Predicting extensively drug-resistant Mycobacterium tuberculosis phenotypes with genetic mutations.
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Evaluation of the AID TB resistance line probe assay for rapid detection of genetic alterations associated with drug resistance in Mycobacterium tuberculosis strains.
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Epistasis between antibiotic resistance mutations drives the evolution of extensively drug-resistant tuberculosis.
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High proportion of heteroresistance in gyrA and gyrB in fluoroquinolone-resistant Mycobacterium tuberculosis clinical isolates.
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mutations in gyrA and gyrB are responsible for fluoroquinolone resistance in M. tuberculosis
Pyrosequencing for rapid detection of tuberculosis resistance in clinical isolates and sputum samples from re-treatment pulmonary tuberculosis patients.
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The structural modeling of the interaction between levofloxacin and the Mycobacterium tuberculosis gyrase catalytic site sheds light on the mechanisms of fluoroquinolones resistant tuberculosis in Colombian clinical isolates.
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A complete high-quality MinION nanopore assembly of an extensively drug-resistant Mycobacterium tuberculosis Beijing lineage strain identifies novel variation in repetitive PE/PPE gene regions.
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Performance of an Xpert-based diagnostic algorithm for the rapid detection of drug-resistant tuberculosis among high-risk populations in a low-incidence setting.
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Molecular detection of rifampin, isoniazid, and ofloxacin resistance in Iranian isolates of Mycobacterium tuberculosis by high-resolution melting analysis.
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Levofloxacin Pharmacokinetics/Pharmacodynamics, Dosing, Susceptibility Breakpoints, and Artificial Intelligence in the Treatment of Multidrug-resistant Tuberculosis.
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Mutations in gyrA were associated with levofloxacin resistance.
Whole-Genome Sequencing of Drug-Resistant Mycobacterium tuberculosis Strains, Tunisia, 2012-2016.
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In silico evaluation of WHO-endorsed molecular methods to detect drug resistant tuberculosis.
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Mutations in gyrA associated with fluoroquinolone resistance
Recent Advances in Methods to Detect Drug-Resistant Mtb
Review
TBProfiler for automated calling of the association with drug resistance of variants in Mycobacterium tuberculosis.
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Variant classified as associated with resistance in the WHO catalogue.
Analysis of drug resistance among difficult-to-treat tuberculosis patients in Ghana identifies several pre-XDR TB cases.
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Clinical utility of target-based next-generation sequencing for drug-resistant TB.
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Mutations in gyrA were identified as a key determinant of fluoroquinolone resistance.
A rapid, accurate, and low-cost method for detecting Mycobacterium tuberculosis and its drug-resistant genes in pulmonary tuberculosis: Applications of MassARRAY DNA mass spectrometry.
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Poor correlation with phenotype
Mycobacterium tuberculosis Intra-Host Evolution Among Drug-Resistant Tuberculosis Patients Failing Treatment.
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Resistance Profiles to Second-Line Anti-Tuberculosis Drugs and Their Treatment Outcomes: A Three-Year Retrospective Analysis from South India.
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Rapid detection of fluoroquinolone resistance in Mycobacterium tuberculosis using a novel multienzyme isothermal rapid assay.
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Mutations in codons 90 and 94 of gyrA are associated with fluoroquinolone resistance.
Molecular Analysis of Anti-Tuberculosis Drug Resistance of Mycobacterium tuberculosis Isolated in the Republic of Korea.
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Analysis of Drug-Resistance Characteristics and Genetic Diversity of Multidrug-Resistant Tuberculosis Based on Whole-Genome Sequencing on the Hainan Island, China.
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Molecular characterization of genetic mutations with fitness loss in pulmonary tuberculosis patients associated with HIV co-infection in Northwest Amhara, Ethiopia.
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Mutation in the gyrA gene is associated with fluoroquinolone resistance.
Monitoring of First-line Drug Resistance Mutations Outside the Scope of Xpert MTB/RIF Ultra is Needed for Successful Control of DR-TB in Southern Mozambique.
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A systematic review of gyrase mutations associated with fluoroquinolone-resistant Mycobacterium tuberculosis and a proposed gyrase numbering system.
Review
Mutations in gyrA codons 90, 91, and 94 are commonly associated with fluoroquinolone resistance.
High-resolution melting analysis for the rapid detection of fluoroquinolone and streptomycin resistance in Mycobacterium tuberculosis.
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Mutations in gyrA were associated with fluoroquinolone resistance.
Rapid diagnosis of drug resistance to fluoroquinolones, amikacin, capreomycin, kanamycin and ethambutol using genotype MTBDRsl assay: a meta-analysis.
Review
Mutations in gyrA gene confer resistance to fluoroquinolones.
Detection of second-line drug resistance in Mycobacterium tuberculosis using oligonucleotide microarrays.
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Fluoroquinolone susceptibility in Mycobacterium tuberculosis after pre-diagnosis exposure to older- versus newer-generation fluoroquinolones.
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Mutations at codon 94 in gyrA were associated with higher fluoroquinolone MICs.
Primary multidrug-resistant Mycobacterium tuberculosis in 2 regions, Eastern Siberia, Russian Federation.
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Fluoroquinolones, gyrA Not performed
Systematic review of allelic exchange experiments aimed at identifying mutations that confer drug resistance in Mycobacterium tuberculosis.
Review
Mutations in gyrA confer resistance to fluoroquinolones
Programmatically selected multidrug-resistant strains drive the emergence of extensively drug-resistant tuberculosis in South Africa.
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Role of gyrB Mutations in Pre-extensively and Extensively Drug-Resistant Tuberculosis in Thai Clinical Isolates.
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Mutations in gyrA contribute to quinolone resistance in Mycobacterium tuberculosis.
Wild-Type and Non-Wild-Type Mycobacterium tuberculosis MIC Distributions for the Novel Fluoroquinolone Antofloxacin Compared with Those for Ofloxacin, Levofloxacin, and Moxifloxacin.
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This mutation does not confer resistance and was excluded from the analysis.
Sequence Analysis of Fluoroquinolone Resistance-Associated Genes gyrA and gyrB in Clinical Mycobacterium tuberculosis Isolates from Patients Suspected of Having Multidrug-Resistant Tuberculosis in New Delhi, India.
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Heterozygous mutations were observed in 4/27 (14.8%) mutations.
Rapid Microarray-Based Detection of Rifampin, Isoniazid, and Fluoroquinolone Resistance in Mycobacterium tuberculosis by Use of a Single Cartridge.
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Mutations in gyrA were analyzed for their association with resistance to fluoroquinolones.
Multi-clonal evolution of multi-drug-resistant/extensively drug-resistant Mycobacterium tuberculosis in a high-prevalence setting of Papua New Guinea for over three decades.
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Mutations promoted from gene entry 'gyrA' (model emitted mutations_found inside genes).
Whole-Genome Analysis of Mycobacterium tuberculosis from Patients with Tuberculous Spondylitis, Russia.
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Interaction between rpsL and gyrA mutations affects the fitness and dual resistance of Mycobacterium tuberculosis clinical isolates against streptomycin and fluoroquinolones.
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Phylogenomic assessment of drug-resistant Mycobacterium tuberculosis strains from Beira, Mozambique.
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Multidrug- and Extensively Drug-Resistant Mycobacterium tuberculosis Beijing Clades, Ukraine, 2015.
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Mutations promoted from gene entry 'gyrA' (model emitted mutations_found inside genes).
Performance of Genotype MTBDRsl V2.0 over the Genotype MTBDRsl V1 for detection of second line drug resistance: An Indian perspective.
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Second-line Drug Resistance Characterization in Mycobacterium tuberculosis by Genotype MTBDRsl Assay.
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gyrA MUT3C
Resistance-Conferring Mutations on Whole-Genome Sequencing of Fluoroquinolone-resistant and -Susceptible Mycobacterium tuberculosis Isolates: A Proposed Threshold for Identifying Resistance.
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Mutations in gyrA and gyrB are the most frequent mechanism of fluoroquinolone resistance.
Detection of drug resistant Mycobacterium tuberculosis by high-throughput sequencing of DNA isolated from acid fast bacilli smears.
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Mutation in gyrA is associated with fluoroquinolone, moxifloxacin, and ofloxacin resistance.
Fluoroquinolone resistance and mutational profile of gyrA in pulmonary MDR tuberculosis patients.
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Mutations in gyrA are associated with high-level resistance to fluoroquinolones.
ODELAM, rapid sequence-independent detection of drug resistance in isolates of Mycobacterium tuberculosis.
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The D94G mutation in gyrA is responsible for ofloxacin resistance in TRS10 and ADB42.
Fitness Cost and Compensatory Evolution in Levofloxacin-Resistant Mycobacterium aurum.
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mutations in quinolone-resistance-determining region of gyrA gene
Case Report: Dynamics of Acquired Fluoroquinolone Resistance under Standardized Short-Course Treatment of Multidrug-Resistant Tuberculosis.
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gyrA D94G mutation detected in month 9 sample and culture isolate
Characterisation of drug-resistant Mycobacterium tuberculosis mutations and transmission in Pakistan.
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A data compendium associating the genomes of 12,289 Mycobacterium tuberculosis isolates with quantitative resistance phenotypes to 13 antibiotics.
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mutations in gyrA are associated with fluoroquinolone resistance
Mycobacterium tuberculosis gyrA conferring resistance to fluoroquinolones; CARD accession: CARD:3003295
High fluoroquinolone resistance proportions among multidrug-resistant tuberculosis driven by dominant L2 Mycobacterium tuberculosis clones in the Mumbai Metropolitan Region.
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Mutations in gyrA are associated with fluoroquinolone resistance.
Predicting antibiotic resistance in complex protein targets using alchemical free energy methods.
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Resistant to moxifloxacin
Whole-genome sequencing for surveillance of fluoroquinolone resistance in rifampicin-susceptible tuberculosis in a rural district of Shanghai: A 10-year retrospective study.
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Mutations in gyrA were associated with fluoroquinolone resistance in Mycobacterium tuberculosis.
Whole Genome Sequencing of Mycobacterium tuberculosis under routine conditions in a high-burden area of multidrug-resistant tuberculosis in Peru.
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Evaluation of genetic correlation with fluoroquinolones resistance in rifampicin-resistant Mycobacterium tuberculosis isolates.
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Asp94Gly was the most common mutation in gyrA associated with high-level resistance to LFX and MFX.
Risk assessment and transmission of fluoroquinolone resistance in drug-resistant pulmonary tuberculosis: a retrospective genomic epidemiology study.
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Most common mutation in fluoroquinolone-resistant isolates
Characterization of mutations in multi- and extensive drug resistance among strains of Mycobacterium tuberculosis clinical isolates in Republic of Korea.
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Genome sequencing of 161 Mycobacterium tuberculosis isolates from China identifies genes and intergenic regions associated with drug resistance.
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Triplex real-time PCR melting curve analysis for detecting Mycobacterium tuberculosis mutations associated with resistance to second-line drugs in a single reaction.
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Detection of streptomycin and quinolone resistance in Mycobacterium tuberculosis by a low-density DNA array.
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Detection of first- and second-line drug resistance in Mycobacterium tuberculosis clinical isolates by pyrosequencing.
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Evaluation of genotype MTBDRsl assay to detect drug resistance associated with fluoroquinolones, aminoglycosides and ethambutol on clinical sediments.
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Tuberculosis drug resistance mutation database.
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Integrating standardized whole genome sequence analysis with a global Mycobacterium tuberculosis antibiotic resistance knowledgebase.
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Mycobacterium tuberculosis gyrA conferring resistance to fluoroquinolones; CARD accession: CARD:3003295
Molecular detection of mutations associated with first- and second-line drug resistance compared with conventional drug susceptibility testing of Mycobacterium tuberculosis.
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Mycobacterium tuberculosis gyrA conferring resistance to fluoroquinolones; CARD accession: CARD:3003295
Mycobacterium tuberculosis gyrA conferring resistance to fluoroquinolones; CARD accession: CARD:3003295
Development and validation of a diagnostic DNA microarray to detect quinolone-resistant Escherichia coli among clinical isolates.
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Single nucleotide exchange at position 83
Clinical and molecular characteristics of Chryseobacterium indologenes isolates at a teaching hospital in Shanghai, China.
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Mutations in GyrA contribute to quinolone resistance.
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