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Browse Mutations pbp3A413V

Genepbp3

penicillin-binding protein

Protein ChangeA413V

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: altered the structural loop adjacent to the active site, potentially diminishing the binding affinity of aztreonam
Resistance To: ceftazidime, aztreonam
Organisms: Klebsiella pneumoniae
Papers: 1

Paper Information1

1

From genomics to treatment: overcoming pan-drug-resistant Klebsiella pneumoniae in clinical settings.

Research Article

PMID 40520176 · 2025

Mutation Information

Protein Change: A413V
Organisms: Klebsiella pneumoniae
Confers Resistance To: ceftazidimeaztreonam
Effect on Function: altered the structural loop adjacent to the active site, potentially diminishing the binding affinity of aztreonam
Validation Method: whole-genome sequencing and MIC testing
Source Database: Reslit

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
Help
GitHub
Zenodo archive
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research