ResLit - Antimicrobial Resistance Gene & Mutation Database

Penicillin-binding protein 1

Protein ChangeS314A

Validation StatusCandidate

Databases

Reslit

Overview

Paper Information1

Evidence for a dual role of PBP1 in the cell division and cell separation of Staphylococcus aureus.

Research Article

The S314A mutation in the TPase domain of PBP1 leads to loss of transpeptidase activity and impairs cell division and growth.

Protein Change: S314A
Organisms: Staphylococcus aureus
Confers Resistance To: penicillin
Validation Method: Functional assay demonstrating loss of TPase activity and growth impairment
Source Database: Reslit

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