Browse AMR Mutations
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
Overview
Topoisomerase sequences of coagulase-negative staphylococcal isolates resistant to ciprofloxacin or trovafloxacin.
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Mutation in gyrA codon 84 associated with ciprofloxacin resistance.
Quinolone resistance in Staphylococci: activities of new nonfluorinated quinolones against molecular targets in whole cells and clinical isolates.
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Mutations promoted from gene entry 'gyrA' (model emitted mutations_found inside genes).
Target preference of 15 quinolones against Staphylococcus aureus, based on antibacterial activities and target inhibition.
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Bactericidal activities of BMS-284756, a novel Des-F(6)-quinolone, against Staphylococcus aureus strains with topoisomerase mutations.
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Characterization of new staphylococcal cassette chromosome mec (SCCmec) and topoisomerase genes in fluoroquinolone- and methicillin-resistant Staphylococcus pseudintermedius.
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gyrA
In vitro evaluation of CBR-2092, a novel rifamycin-quinolone hybrid antibiotic: studies of the mode of action in Staphylococcus aureus.
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Skin lesion caused by ST398 and ST1 MRSA, Spain.
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Bactericidal activity of besifloxacin against staphylococci, Streptococcus pneumoniae and Haemophilus influenzae.
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Empyema caused by MRSA ST398 with atypical resistance profile, Spain.
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In vitro and in vivo profiles of ACH-702, an isothiazoloquinolone, against bacterial pathogens.
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Mutation in gyrA (Ser84Leu) leads to fluoroquinolone resistance.
Genomic and Long-Term Transcriptomic Imprints Related to the Daptomycin Mechanism of Action Occurring in Daptomycin- and Methicillin-Resistant Staphylococcus aureus Under Daptomycin Exposure.
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Mutation in gyrA gene leading to reduced susceptibility to fluoroquinolones
Comparative genomics of ST5 and ST30 methicillin-resistant Staphylococcus aureus sequential isolates recovered from paediatric patients with cystic fibrosis.
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mutation in isolates
A platform for detecting cross-resistance in antibacterial drug discovery.
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Clonal Lineages, Antimicrobial Resistance, and PVL Carriage of Staphylococcus aureus Associated to Skin and Soft-Tissue Infections from Ambulatory Patients in Portugal.
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Shared and Unique Evolutionary Trajectories to Ciprofloxacin Resistance in Gram-Negative Bacterial Pathogens.
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Mutations in gyrA are responsible for ciprofloxacin resistance in E. coli, A. baumannii, and P. aeruginosa.
Epidemiology of the Staphylococcus aureus CA-MRSA USA300 in Belgium.
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Deciphering the genomic character of the multidrug-resistant Staphylococcus aureus from Dhaka, Bangladesh.
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Combination therapy delays antimicrobial resistance after adaptive laboratory evolution of Staphylococcus aureus.
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Mutations in gyrA were associated with high-level ciprofloxacin resistance
Species Distribution, Antimicrobial Resistance, and Enterotoxin Profiles of Non-aureus Staphylococci Isolated from Poultry Slaughterhouses in Korea.
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Clade-specific adaptation and global spread of Staphylococcus aureus ST188 with emergence of a multidrug-resistant MRSA sublineage.
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Fluoroquinolone resistance mutation
Activities of trovafloxacin compared with those of other fluoroquinolones against purified topoisomerases and gyrA and grlA mutants of Staphylococcus aureus.
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mutation in gyrA gene
Activities and postantibiotic effects of gemifloxacin compared to those of 11 other agents against Haemophilus influenzae and Moraxella catarrhalis.
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Induction of fibronectin-binding proteins and increased adhesion of quinolone-resistant Staphylococcus aureus by subinhibitory levels of ciprofloxacin.
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Dual targeting of DNA gyrase and topoisomerase IV: target interactions of garenoxacin (BMS-284756, T-3811ME), a new desfluoroquinolone.
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Evolution of Ciprofloxacin-Resistant Staphylococcus aureus in In Vitro Pharmacokinetic Environments
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Mutation detected in gyrA QRDR
Reduced levofloxacin susceptibility and tetracycline resistance in a clinical isolate of Haemophilus quentini identified by 16S rRNA sequencing.
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In vitro evaluation of CBR-2092, a novel rifamycin-quinolone hybrid antibiotic: microbiology profiling studies with staphylococci and streptococci.
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Mutation in gyrA gene leads to fluoroquinolone resistance.
Genomic analysis of an emerging multiresistant Staphylococcus aureus strain rapidly spreading in cystic fibrosis patients revealed the presence of an antibiotic inducible bacteriophage.
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Exploring the contribution of efflux on the resistance to fluoroquinolones in clinical isolates of Staphylococcus aureus.
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In Vitro Activity of Delafloxacin and Microbiological Response against Fluoroquinolone-Susceptible and Nonsusceptible Staphylococcus aureus Isolates from Two Phase 3 Studies of Acute Bacterial Skin and Skin Structure Infections.
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Antimicrobial Resistance and Virulence of Methicillin-Resistant Staphylococcus aureus from Human, Chicken and Environmental Samples within Live Bird Markets in Three Nigerian Cities.
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The Persister Character of Clinical Isolates of Staphylococcus aureus Contributes to Faster Evolution to Resistance and Higher Survival in THP-1 Monocytes: A Study With Moxifloxacin.
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S. pseudintermedius and S. aureus lineages with transmission ability circulate as causative agents of infections in pets for years.
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Detected in ciprofloxacin-resistant SP isolates
Genome-Wide Association Studies for the Detection of Genetic Variants Associated With Daptomycin and Ceftaroline Resistance in Staphylococcus aureus.
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This mutation is associated with ceftaroline resistance in S. aureus.
High-Level Quinolone-Resistant Haemophilus haemolyticus in Pediatric Patient with No History of Quinolone Exposure.
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Transmission of Methicillin-Resistant Staphylococcus spp. from Infected Dogs to the Home Environment and Owners.
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Genomic analysis of Staphylococcus aureus isolates from bacteremia reveals genetic features associated with the COVID-19 pandemic.
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The circulation of methicillin-resistant Staphylococcus aureus between humans, horses and the environment at the equine clinic.
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Comparative In vitro antibacterial activity of nemonoxacin and other fluoroquinolones in correlation with resistant mechanisms in contemporary methicillin-resistant Staphylococcus aureus blood isolates in Taiwan.
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Skin Infections Caused by Panton-Valentine Leukocidin and Methicillin-Susceptible Staphylococcus aureus in Child, Japan.
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In vitro activities of novel nonfluorinated quinolones PGE 9262932 and PGE 9509924 against clinical isolates of Staphylococcus aureus and Streptococcus pneumoniae with defined mutations in DNA gyrase and topoisomerase IV.
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Mutations in gyrA are associated with quinolone resistance.
Use of a three-dimensional microarray system for detection of levofloxacin resistance and the mecA gene in Staphylococcus aureus.
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Activity of gatifloxacin in an in vitro pharmacokinetic-pharmacodynamic model against Staphylococcus aureus strains either susceptible to ciprofloxacin or exhibiting various levels and mechanisms of ciprofloxacin resistance.
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Community-acquired methicillin-resistant Staphylococcus aureus: community transmission, pathogenesis, and drug resistance.
Review
Antistaphylococcal activities of the new fluoroquinolone JNJ-Q2
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Single Ser84Leu GyrA substitution elevated JNJ-Q2 MICs by 4-fold
A genomic portrait of the emergence, evolution, and global spread of a methicillin-resistant Staphylococcus aureus pandemic.
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Implanted Port Catheter System Infection Caused by Methicillin-resistant Staphylococcus pseudintermedius ST71-SCCmec type III.
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Virulence Determinants in Staphylococcus aureus Clones Causing Osteomyelitis in Italy.
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Methicillin-resistant Staphylococcus aureus outbreak in a Dutch equine referral clinic.
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Dissecting the genetic features and evolution of Staphylococcus aureus sequence type 88: a global perspective.
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Present in most quinolone-resistant ST88 strains.
Genomic insights into the spread of methicillin-resistant Staphylococcus aureus involved in ear infections.
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Genomic analysis of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) causing infections in children-a Spanish multicenter study.
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Transmission and microevolution of USA300 MRSA in U.S. households: evidence from whole-genome sequencing.
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Deoxynybomycins inhibit mutant DNA gyrase and rescue mice infected with fluoroquinolone-resistant bacteria.
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Mutations in GyrA are responsible for fluoroquinolone resistance and are targeted by deoxynybomycin.
Single-molecule sequencing reveals the molecular basis of multidrug-resistance in ST772 methicillin-resistant Staphylococcus aureus.
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Healthcare- and Community-Associated Methicillin-Resistant Staphylococcus aureus (MRSA) and Fatal Pneumonia with Pediatric Deaths in Krasnoyarsk, Siberian Russia: Unique MRSA's Multiple Virulence Factors, Genome, and Stepwise Evolution.
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Characterization of mannitol-fermenting methicillin-resistant staphylococci isolated from pigs in Nigeria.
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Additional substitutions in some isolates: Ser98Ile and Arg100Lys in S. lentus strain C4022; Glu88Asp and Asp96Thr in S. sciuri C3997 and S. lentus C4005
Demography and Intercontinental Spread of the USA300 Community-Acquired Methicillin-Resistant Staphylococcus aureus Lineage.
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Molecular characterization of fluoroquinolones, macrolides, and imipenem resistance in Haemophilus influenzae: analysis of the mutations in QRDRs and assessment of the extent of the AcrAB-TolC-mediated resistance.
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In Vitro Derivation of Fluoroquinolone-Resistant Mutants from Multiple Lineages of Haemophilus influenzae and Identification of Mutations Associated with Fluoroquinolone Resistance.
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In Vitro Activity and Microbiological Efficacy of Gepotidacin from a Phase 2, Randomized, Multicenter, Dose-Ranging Study in Patients with Acute Bacterial Skin and Skin Structure Infections.
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Characterization of the First mecA-Positive Multidrug-Resistant Staphylococcus pseudintermedius Isolated from an Argentinian Patient.
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A Comparative Phenotypic and Genomic Analysis of Methicillin-Resistant Staphylococcus aureus ST45 Isolates From Cellulitis and Osteomyelitis in Taiwan.
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Detected only in OM-MRSA strains
Detection of grlA and gyrA mutations in 344 Staphylococcus aureus strains.
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Y-688, a new quinolone active against quinolone-resistant Staphylococcus aureus: lack of in vivo efficacy in experimental endocarditis.
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Mutation in gyrA was associated with reduced susceptibility to fluoroquinolones.
Genomic Comparison of Highly Virulent, Moderately Virulent, and Avirulent Strains From a Genetically Closely-Related MRSA ST239 Sub-lineage Provides Insights Into Pathogenesis.
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associated with quinolone resistance
Phylogenomics of Staphylococcus aureus CC5: Evolution, Resistance, and Virulence
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associated with fluoroquinolone resistance
Antimicrobial resistance, virulence genes profiling and molecular relatedness of methicillin-resistant Staphylococcus aureus strains isolated from hospitalized patients in Guangdong Province, China.
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In Vitro and In Vivo Activity of Zabofloxacin and Other Fluoroquinolones Against MRSA Isolates from A University Hospital in Egypt.
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Molecular Basis of Non-β-Lactam Antibiotics Resistance in Staphylococcus aureus.
Review
Mutations in gyrA contribute to fluoroquinolone resistance.
Bacterial resistance to antibacterial agents: Mechanisms, control strategies, and implications for global health.
Review
In Vitro and In Vivo Properties of CUO246, a Novel Bacterial DNA Gyrase/Topoisomerase IV Inhibitor.
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CID12261165, a flavonoid compound as antibacterial agents against quinolone-resistant Staphylococcus aureus.
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Mutations in gyrA were associated with resistance to CID12261165 and levofloxacin.
Exploring Efflux as a Mechanism of Reduced Susceptibility towards Biocides and Fluoroquinolones in Staphylococcus pseudintermedius.
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Genomic Diversity of Methicillin-Resistant Staphylococcus aureus CC398 Isolates Collected from Diseased Swine in the German National Resistance Monitoring Program GERM-Vet from 2007 to 2019.
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Phenotypic and genomic analysis of the hypervirulent ST22 methicillin-resistant Staphylococcus aureus in China.
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Fluoroquinolone resistance does not facilitate phage Φ13 integration or excision in Staphylococcus aureus.
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Genomic alterations involved in fluoroquinolone resistance development in Staphylococcus aureus.
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Updated Review on Clinically-Relevant Properties of Delafloxacin.
Review
Most frequent mutation observed in DLX-resistant S. aureus strains
Whole-Genome Sequencing-Based Screening of MRSA in Patients and Healthcare Workers in Public Hospitals in Benin.
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Species Profiles and Antimicrobial Resistance of Non-aureus Staphylococci Isolated from Healthy Broilers, Farm Environments, and Farm Workers.
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First Isolation of Methicillin-Resistant Livestock-Associated Staphylococcus aureus CC398 and CC1 in Intensive Pig Production Farms in Argentina.
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Genetic Determinants in MRSA Carriage and Their Association with Decolonization Outcome.
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Isolation and characterization of Staphylococcus aureus strains from a Paso del Norte dairy.
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mutation in DNA gyrase gene leading to ciprofloxacin resistance
Novel pseudo-staphylococcal cassette chromosome mec element (ψSCCmec57395) in methicillin-resistant Staphylococcus pseudintermedius CC45.
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Prophage-Mediated Disruption of Genetic Competence in Staphylococcus pseudintermedius.
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Mutations in GyrA contribute to fluoroquinolone resistance.
The Antimicrobial Activity of Ciprofloxacin-Loaded Niosomes against Ciprofloxacin-Resistant and Biofilm-Forming Staphylococcus aureus.
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Delafloxacin: A Review in Acute Bacterial Skin and Skin Structure Infections.
Review
Outbreak of methicillin-resistant Staphylococcus aureus sequence type 1, spa type t1784, in an equine hospital in Japan.
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Molecular Mechanisms of Drug Resistance in Staphylococcus aureus.
Review
Clonal distribution and antimicrobial resistance of methicillin-susceptible and -resistant Staphylococcus aureus strains isolated from broiler farms, slaughterhouses, and retail chicken meat.
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Staphylococcus aureus associated with surgical site infections in Western Kenya reveals genomic hotspots for pathogen evolution.
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Antimicrobial Resistance in Coagulase-Negative Staphylococci: Resistome, Mobiloome, and Relatedness
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Mutations in gyrA contribute to ciprofloxacin resistance in multiple CoNS isolates.
DNA gyrase gyrA mutations in ciprofloxacin-resistant strains of Staphylococcus aureus: close similarity with quinolone resistance mutations in Escherichia coli.
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GyrA sequence analysis of Staphylococcus aureus and methicillin-resistant S. aureus strains selected, in vitro, for high-level ciprofloxacin resistance.
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Topoisomerase mutations that are associated with high-level resistance to earlier fluoroquinolones in Staphylococcus aureus have less effect on the antibacterial activity of besifloxacin.
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Staphylococcus aureus gyrA conferring resistance to fluoroquinolones; CARD accession: CARD:3003296
Multiple interspecies recombination events documented by whole-genome sequencing in multidrug-resistant Haemophilus influenzae clinical isolates.
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gyrA
Emerging carbapenem-resistant Klebsiella pneumoniae sequence type 16 causing multiple outbreaks in a tertiary hospital in southern Vietnam.
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Mutations in gyrA contribute to fluoroquinolone resistance.
Fluoroquinolone and other antimicrobial resistance in invasive pneumococci, Hong Kong, 1995-2001.
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Mutations in gyrA contribute to fluoroquinolone resistance.
Informal genomic surveillance of regional distribution of Salmonella Typhi genotypes and antimicrobial resistance via returning travellers.
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Mutations in the quinolone resistance determining region (QRDR) of gyrA and parC are associated with reduced susceptibility to fluoroquinolones.
A retrospective investigation of the population structure and geospatial distribution of Salmonella Paratyphi A in Kathmandu, Nepal.
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Mutations in gyrA were associated with reduced susceptibility to fluoroquinolones.
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