Browse AMR Mutations
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
Overview
Structural insights into the quinolone resistance mechanism of Mycobacterium tuberculosis DNA gyrase.
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Mutations in the quinolone resistance-determining regions (QRDR) of GyrA and GyrB.
GenoType MTBDRsl for molecular detection of second-line-drug and ethambutol resistance in Mycobacterium tuberculosis strains and clinical samples.
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Mutations in gyrA were associated with resistance to fluoroquinolones.
Characterization of gyrA and gyrB mutations and fluoroquinolone resistance in Mycobacterium tuberculosis clinical isolates from Hubei Province, China.
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Dominant incidence of multidrug and extensively drug-resistant specific Mycobacterium tuberculosis clones in Osaka Prefecture, Japan.
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The variability and reproducibility of whole genome sequencing technology for detecting resistance to anti-tuberculous drugs.
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Computational modeling and bioinformatic analyses of functional mutations in drug target genes in Mycobacterium tuberculosis.
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Prevalence of extensively drug-resistant tuberculosis in a Chinese multidrug-resistant TB cohort after redefinition.
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Whole-genome sequencing of Mycobacterium tuberculosis for prediction of drug resistance.
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Mutations in gyrA were associated with ofloxacin resistance.
Rifampicin and isoniazid resistance not promote fluoroquinolone resistance in Mycobacterium smegmatis.
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Multiplex PCR amplimer conformation analysis for rapid detection of gyrA mutations in fluoroquinolone-resistant Mycobacterium tuberculosis clinical isolates.
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Evaluation of a new line probe assay for rapid identification of gyrA mutations in Mycobacterium tuberculosis.
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associated with fluoroquinolone resistance
Sequence analyses of just four genes to detect extensively drug-resistant Mycobacterium tuberculosis strains in multidrug-resistant tuberculosis patients undergoing treatment.
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Comparative study on genotypic and phenotypic second-line drug resistance testing of Mycobacterium tuberculosis complex isolates.
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mutations detected in 7 strains
Rapid diagnosis of extensively drug-resistant tuberculosis by use of a reverse line blot hybridization assay.
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Incidence of moxifloxacin resistance in clinical Mycobacterium tuberculosis isolates in Houston, Texas.
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Drug-resistant tuberculosis in Central Mozambique: the role of a rapid genotypic susceptibility testing.
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Molecular characteristics of ofloxacin mono-resistant Mycobacterium tuberculosis isolates from new and previously treated tuberculosis patients.
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Fluoroquinolone Resistance Mutation Detection Is Equivalent to Culture-Based Drug Sensitivity Testing for Predicting Multidrug-Resistant Tuberculosis Treatment Outcome: A Retrospective Cohort Study.
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Mutations in gyrA and gyrB are associated with fluoroquinolone resistance in Mycobacterium tuberculosis.
Xpert MTB/XDR: a 10-Color Reflex Assay Suitable for Point-of-Care Settings To Detect Isoniazid, Fluoroquinolone, and Second-Line-Injectable-Drug Resistance Directly from Mycobacterium tuberculosis-Positive Sputum.
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Increasing prevalence of resistance to second-line drugs among multidrug-resistant Mycobacterium tuberculosis isolates in Kuwait.
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Evolution and emergence of multidrug-resistant Mycobacterium tuberculosis in Chisinau, Moldova.
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Multiple gyrA mutations (D94G, D94A, A90V) confer resistance to fluoroquinolones.
Analysis on Drug-Resistance-Associated Mutations among Multidrug-Resistant Mycobacterium tuberculosis Isolates in China.
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A modified decision tree approach to improve the prediction and mutation discovery for drug resistance in Mycobacterium tuberculosis.
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Application of Amplicon-Based Targeted NGS Technology for Diagnosis of Drug-Resistant Tuberculosis Using FFPE Specimens.
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high-confidence mutation
Whole genome sequencing analysis of Mycobacterium tuberculosis reveals circulating strain types and drug-resistance mutations in the Philippines.
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Common mutations underlying fluoroquinolone resistance.
Whole-genome sequencing reveals transmission pattern and drug resistance of Mycobacterium tuberculosis intra- or inter-hosts.
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Identification and quantification of gyrA variants in fluoroquinolone-resistant Mycobacterium tuberculosis in a MeltArray reaction.
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All mutations are in the quinolone resistance-determining region (QRDR) of gyrA.
Genomic characterization of XDR Mycobacterium tuberculosis isolates in Argentina (2006-2015).
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Association of mutation patterns in gyrA/B genes and ofloxacin resistance levels in Mycobacterium tuberculosis isolates from East China in 2009.
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The S95T mutation in gyrA was a natural polymorphism and not considered a resistance mechanism.
FIND Tuberculosis Strain Bank: a Resource for Researchers and Developers Working on Tests To Detect Mycobacterium tuberculosis and Related Drug Resistance.
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Some Synonymous and Nonsynonymous gyrA Mutations in Mycobacterium tuberculosis Lead to Systematic False-Positive Fluoroquinolone Resistance Results with the Hain GenoType MTBDRsl Assays.
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Mutations in gyrA lead to false-positive fluoroquinolone resistance results
Correlation of gyr Mutations with the Minimum Inhibitory Concentrations of Fluoroquinolones among Multidrug-Resistant Mycobacterium tuberculosis Isolates in Bangladesh.
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Mutations in the gyrA gene are associated with fluoroquinolone resistance in MDR-TB isolates.
Performance of GenoType MTBDRsl assay for detection of second-line drugs and ethambutol resistance directly from sputum specimens of MDR-TB patients in Bangladesh.
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Use of Whole-Genome Sequencing to Predict Mycobacterium tuberculosis Complex Drug Resistance from Early Positive Liquid Cultures.
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Whole genomic analysis uncovers high genetic diversity of rifampicin-resistant Mycobacterium tuberculosis strains in Botswana.
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Evaluation of the Xpert MTB/XDR test for detection of isoniazid, fluoroquinolones, and second-line injectable drugs resistance to Mycobacterium tuberculosis-Anhui Province, China.
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A novel one-tube nested fluorescence melting curve analysis for rapid detection of drug-resistant Mycobacterium tuberculosis.
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All mutations were confirmed by DNA sequencing.
Characterization of extensively drug-resistant Mycobacterium tuberculosis isolates circulating in Siberia.
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associated with ofloxacin resistance
Unraveling Mycobacterium tuberculosis genomic diversity and evolution in Lisbon, Portugal, a highly drug resistant setting.
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Mutations in gyrA are associated with fluoroquinolone resistance.
Correlating Minimum Inhibitory Concentrations of ofloxacin and moxifloxacin with gyrA mutations using the genotype MTBDRsl assay.
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Mutations in gyrA are associated with fluoroquinolone resistance in Mycobacterium tuberculosis.
Molecular diagnosis of fluoroquinolone resistance in Mycobacterium tuberculosis.
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Mutations in gyrA are associated with fluoroquinolone resistance.
Frequency and geographic distribution of gyrA and gyrB mutations associated with fluoroquinolone resistance in clinical Mycobacterium tuberculosis isolates: a systematic review.
Review
Mutations in gyrA are associated with fluoroquinolone resistance in Mycobacterium tuberculosis.
Comparative Evaluation of Sloppy Molecular Beacon and Dual-Labeled Probe Melting Temperature Assays to Identify Mutations in Mycobacterium tuberculosis Resulting in Rifampin, Fluoroquinolone and Aminoglycoside Resistance.
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Correlation between GyrA substitutions and ofloxacin, levofloxacin, and moxifloxacin cross-resistance in Mycobacterium tuberculosis.
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Mutations in gyrA QRDR correlate with increased MICs for fluoroquinolones.
Diagnostic Performance of the New Version (v2.0) of GenoType MTBDRsl Assay for Detection of Resistance to Fluoroquinolones and Second-Line Injectables Drugs: a Multicenter Study.
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Determination of MICs of levofloxacin for Mycobacterium tuberculosis with gyrA mutations.
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Mutations in gyrA were correlated with levofloxacin resistance.
Gyrase Mutations Are Associated with Variable Levels of Fluoroquinolone Resistance in Mycobacterium tuberculosis.
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MTBDRplus and MTBDRsl Assays: Absence of Wild-Type Probe Hybridization and Implications for Detection of Drug-Resistant Tuberculosis.
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Development and evaluation of novel bio-safe filter paper-based kits for sputum microscopy and transport to directly detect Mycobacterium tuberculosis and associated drug resistance.
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Prevalence, risk and genetic characteristics of drug-resistant tuberculosis in a tertiary care tuberculosis hospital in China.
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Whole genome sequencing of drug resistant Mycobacterium tuberculosis isolates from a high burden tuberculosis region of North West Pakistan.
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Phenotypic and genotypic characterization of levofloxacin- and moxifloxacin-resistant Mycobacterium tuberculosis clinical isolates in southern China.
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Novel mutations detected in gyrA and gyrB genes.
Epidemiological cut-offs for Sensititre susceptibility testing of Mycobacterium tuberculosis: interpretive criteria cross validated with whole genome sequencing.
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Rapid detection of multidrug resistance in tuberculosis using nanopore-based targeted next-generation sequencing: a multicenter, double-blind study.
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Common mutation in gyrA
Patterns and profiles of drug resistance-conferring mutations in Mycobacterium tuberculosis genotypes isolated from tuberculosis-suspected attendees of spiritual holy water sites in Northwest Ethiopia.
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Only mutation found in FLQ-resistant isolates
Predicting extensively drug-resistant Mycobacterium tuberculosis phenotypes with genetic mutations.
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Evaluation of the AID TB resistance line probe assay for rapid detection of genetic alterations associated with drug resistance in Mycobacterium tuberculosis strains.
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Pyrosequencing for rapid detection of tuberculosis resistance in clinical isolates and sputum samples from re-treatment pulmonary tuberculosis patients.
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Whole-Genome Sequencing of Drug-Resistant Mycobacterium tuberculosis Strains, Tunisia, 2012-2016.
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In silico evaluation of WHO-endorsed molecular methods to detect drug resistant tuberculosis.
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Mutations in gyrA associated with fluoroquinolone resistance
Rapid detection of fluoroquinolone resistance in Mycobacterium tuberculosis using a novel multienzyme isothermal rapid assay.
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Mutations in codons 90 and 94 of gyrA are associated with fluoroquinolone resistance.
Monitoring of First-line Drug Resistance Mutations Outside the Scope of Xpert MTB/RIF Ultra is Needed for Successful Control of DR-TB in Southern Mozambique.
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A systematic review of gyrase mutations associated with fluoroquinolone-resistant Mycobacterium tuberculosis and a proposed gyrase numbering system.
Review
Mutations in gyrA codons 90, 91, and 94 are commonly associated with fluoroquinolone resistance.
High-resolution melting analysis for the rapid detection of fluoroquinolone and streptomycin resistance in Mycobacterium tuberculosis.
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Mutations in gyrA were associated with fluoroquinolone resistance.
Rapid diagnosis of drug resistance to fluoroquinolones, amikacin, capreomycin, kanamycin and ethambutol using genotype MTBDRsl assay: a meta-analysis.
Review
Mutations in gyrA gene confer resistance to fluoroquinolones.
Detection of second-line drug resistance in Mycobacterium tuberculosis using oligonucleotide microarrays.
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Primary multidrug-resistant Mycobacterium tuberculosis in 2 regions, Eastern Siberia, Russian Federation.
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Fluoroquinolones, gyrA Not performed
Role of gyrB Mutations in Pre-extensively and Extensively Drug-Resistant Tuberculosis in Thai Clinical Isolates.
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Mutations in gyrA contribute to quinolone resistance in Mycobacterium tuberculosis.
Sequence Analysis of Fluoroquinolone Resistance-Associated Genes gyrA and gyrB in Clinical Mycobacterium tuberculosis Isolates from Patients Suspected of Having Multidrug-Resistant Tuberculosis in New Delhi, India.
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Heterozygous mutations were observed in 4/27 (14.8%) mutations.
Multi-clonal evolution of multi-drug-resistant/extensively drug-resistant Mycobacterium tuberculosis in a high-prevalence setting of Papua New Guinea for over three decades.
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Mutations promoted from gene entry 'gyrA' (model emitted mutations_found inside genes).
Whole-Genome Analysis of Mycobacterium tuberculosis from Patients with Tuberculous Spondylitis, Russia.
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Interaction between rpsL and gyrA mutations affects the fitness and dual resistance of Mycobacterium tuberculosis clinical isolates against streptomycin and fluoroquinolones.
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Antibiotic resistance prediction for Mycobacterium tuberculosis from genome sequence data with Mykrobe.
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Variant D94A in gyrA gene causes resistance to ciprofloxacin.
Metabolic Changes of Mycobacterium tuberculosis during the Anti-Tuberculosis Therapy.
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Multidrug- and Extensively Drug-Resistant Mycobacterium tuberculosis Beijing Clades, Ukraine, 2015.
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Mutations promoted from gene entry 'gyrA' (model emitted mutations_found inside genes).
Resistance-Conferring Mutations on Whole-Genome Sequencing of Fluoroquinolone-resistant and -Susceptible Mycobacterium tuberculosis Isolates: A Proposed Threshold for Identifying Resistance.
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Mutations in gyrA and gyrB are the most frequent mechanism of fluoroquinolone resistance.
Fluoroquinolone resistance and mutational profile of gyrA in pulmonary MDR tuberculosis patients.
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Mutations in gyrA are associated with high-level resistance to fluoroquinolones.
Antimicrobial Susceptibility and Characterization of Resistance Mechanisms of Corynebacterium urealyticum Clinical Isolates.
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A data compendium associating the genomes of 12,289 Mycobacterium tuberculosis isolates with quantitative resistance phenotypes to 13 antibiotics.
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mutations in gyrA are associated with fluoroquinolone resistance
Mycobacterium tuberculosis gyrA conferring resistance to fluoroquinolones; CARD accession: CARD:3003295
Whole-genome sequencing for surveillance of fluoroquinolone resistance in rifampicin-susceptible tuberculosis in a rural district of Shanghai: A 10-year retrospective study.
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Mutations in gyrA were associated with fluoroquinolone resistance in Mycobacterium tuberculosis.
Whole Genome Sequencing of Mycobacterium tuberculosis under routine conditions in a high-burden area of multidrug-resistant tuberculosis in Peru.
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Characterization of mutations in multi- and extensive drug resistance among strains of Mycobacterium tuberculosis clinical isolates in Republic of Korea.
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Genome sequencing of 161 Mycobacterium tuberculosis isolates from China identifies genes and intergenic regions associated with drug resistance.
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Triplex real-time PCR melting curve analysis for detecting Mycobacterium tuberculosis mutations associated with resistance to second-line drugs in a single reaction.
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Detection of streptomycin and quinolone resistance in Mycobacterium tuberculosis by a low-density DNA array.
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Detection of first- and second-line drug resistance in Mycobacterium tuberculosis clinical isolates by pyrosequencing.
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Evaluation of genotype MTBDRsl assay to detect drug resistance associated with fluoroquinolones, aminoglycosides and ethambutol on clinical sediments.
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Tuberculosis drug resistance mutation database.
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Systematic review of allelic exchange experiments aimed at identifying mutations that confer drug resistance in Mycobacterium tuberculosis.
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Integrating standardized whole genome sequence analysis with a global Mycobacterium tuberculosis antibiotic resistance knowledgebase.
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Mycobacterium tuberculosis gyrA conferring resistance to fluoroquinolones; CARD accession: CARD:3003295
Molecular detection of mutations associated with first- and second-line drug resistance compared with conventional drug susceptibility testing of Mycobacterium tuberculosis.
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Mycobacterium tuberculosis gyrA conferring resistance to fluoroquinolones; CARD accession: CARD:3003295
Mycobacterium tuberculosis gyrA conferring resistance to fluoroquinolones; CARD accession: CARD:3003295
Globally diverse Mycobacterium tuberculosis resistance acquisition: a retrospective geographical and temporal analysis of whole genome sequences.
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Anti-tuberculosis drug resistance in Slovakia, 2018-2019: The first whole-genome epidemiological study.
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Potential of nanopore sequencing for tuberculosis diagnosis and drug resistance detection.
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Translating drug resistant tuberculosis treatment guidelines to reality in war-torn Kandahar, Afghanistan: A retrospective cohort study.
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Mutations in gyrA were identified in 7 (24.1%) of patients.
c-di-AMP signaling plays important role in determining antibiotic tolerance phenotypes of Mycobacterium smegmatis.
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Mutation in the quinolone resistance-determining region (QRDR) of gyrA leads to ciprofloxacin resistance.
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