ResLit - Antimicrobial Resistance Gene & Mutation Database

Protein ChangeG147D

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: abolishing phosphatidylglycerophosphate synthase activity
Resistance To: Daptomycin
Organisms: Corynebacterium striatum
Papers: 1

Paper Information1

Rapid acquisition of daptomycin resistance in a Corynebacterium striatum osteoarticular infection: case report and discussion on antimicrobial resistance.

PMID 41244273 · 2025

The G147D mutation introduces a premature stop codon in the active site of the PgsA enzyme, abolishing phosphatidylglycerophosphate synthase activity.

Mutation Information

pgsA: p.G147D

Protein Change: G147D
Organisms: Corynebacterium striatum
Confers Resistance To

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Mutation Information