Browse AMR Mutations
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
Overview
Detection of rpoB mutations associated with rifampin resistance in Mycobacterium tuberculosis using denaturing gradient gel electrophoresis.
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all mutations are in the rpoB gene and confer resistance to rifampin
The beginning of the rpoB gene in addition to the rifampin resistance determination region might be needed for identifying rifampin/rifabutin cross-resistance in multidrug-resistant Mycobacterium tuberculosis isolates from Southern China.
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Rapid detection of rpoB mutations in rifampin resistant M. tuberculosis from sputum samples by denaturing gradient gel electrophoresis.
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mutations in rpoB gene associated with rifampin resistance
Study of the rifampin monoresistance mechanism in Mycobacterium tuberculosis.
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Mutations in the rpoB gene are responsible for rifampin resistance.
DNA Breaks-Mediated Fitness Cost Reveals RNase HI as a New Target for Selectively Eliminating Antibiotic-Resistant Bacteria.
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Rif R mutation
Antimicrobial Resistance in Mycobacterium tuberculosis Clinical Isolates from HIV-Positive and HIV-Negative Patients in Russia
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Positive epistasis drives the acquisition of multidrug resistance.
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Mutation analysis of mycobacterial rpoB genes and rifampin resistance using recombinant Mycobacterium smegmatis.
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All mutations were experimentally validated in this study.
Rapid and accurate detection of RMP- and INH- resistant Mycobacterium tuberculosis in spinal tuberculosis specimens by CapitalBio™ DNA microarray: a prospective validation study.
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Mutations in rpoB were detected in RMP-resistant M. tuberculosis isolates.
Assessment of a 96-Well Plate Assay of Quantitative Drug Susceptibility Testing for Mycobacterium Tuberculosis Complex in China.
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Direct Detection of Rifampin and Isoniazid Resistance in Sputum Samples from Tuberculosis Patients by High-Resolution Melt Curve Analysis.
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Plasmid-based high-resolution melting analysis for accurate detection of rpoB mutations in Mycobacterium tuberculosis isolates from Moroccan patients.
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Five rifampicin-resistant isolates lacked mutations in the rpoB amplified region.
A Rapid Drug Resistance Genotyping Workflow for Mycobacterium tuberculosis, Using Targeted Isothermal Amplification and Nanopore Sequencing.
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Mutations in rpoB confer resistance to rifampin
Molecular evidence for heterogeneity of the multiple-drug-resistant Mycobacterium tuberculosis population in Scotland (1990 to 1997).
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Mutations in rpoB are associated with rifampin resistance.
New real-time PCR able to detect in a single tube multiple rifampin resistance mutations and high-level isoniazid resistance mutations in Mycobacterium tuberculosis.
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Mutations in rpoB gene associated with rifampin resistance
Evaluation of the TB-Biochip oligonucleotide microarray system for rapid detection of rifampin resistance in Mycobacterium tuberculosis.
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High-resolution melting curve analysis for rapid detection of rifampin and isoniazid resistance in Mycobacterium tuberculosis clinical isolates.
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Mutations in rpoB gene are associated with rifampin resistance.
Frequency and Type of Disputed rpoB Mutations in Mycobacterium tuberculosis Isolates from South Korea.
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Disputed rpoB mutations causing low-level resistance to rifampin
The New Xpert MTB/RIF Ultra: Improving Detection of Mycobacterium tuberculosis and Resistance to Rifampin in an Assay Suitable for Point-of-Care Testing.
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Mutations in rpoB were analyzed for their effect on rifampin resistance.
Mutations in rpoB and katG genes of multidrug resistant mycobacterium tuberculosis undetectable using genotyping diagnostic methods.
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All mutations were identified through sequencing and are associated with rifampicin resistance.
Dynamics of Extensive Drug Resistance Evolution of Mycobacterium tuberculosis in a Single Patient During 9 Years of Disease and Treatment.
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Disputed rpoB Mutations in Mycobacterium tuberculosis and Tuberculosis Treatment Outcomes.
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Mutations in the rpoB gene were associated with rifampin resistance in Mycobacterium tuberculosis.
Discordance in genotypic and phenotypic drug susceptibility results: time to reconsider critical concentration of rifampicin.
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Commonest mutation
Nanopore-based targeted next-generation sequencing (tNGS): A versatile technology specialized in detecting low bacterial load clinical specimens.
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All mutations were identified in the rpoB gene, with 20 located in the rifampicin resistance-determining region (RRDR) and one outside the RRDR.
Patterns of compensatory mutations in rpoA/B/C genes of multidrug resistant M. tuberculosis in Uganda.
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Mutations in rpoB are associated with rifampicin resistance.
Patterns of compensatory mutations in rpoA/B/C genes of multidrug resistant M. tuberculosis in Uganda.
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Some mutations are classified as low-level resistance-conferring.
A novel one-tube nested fluorescence melting curve analysis for rapid detection of drug-resistant Mycobacterium tuberculosis.
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All mutations were confirmed by DNA sequencing.
Comparative Evaluation of Sloppy Molecular Beacon and Dual-Labeled Probe Melting Temperature Assays to Identify Mutations in Mycobacterium tuberculosis Resulting in Rifampin, Fluoroquinolone and Aminoglycoside Resistance.
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Predicting differential rifamycin resistance in clinical Mycobacterium tuberculosis isolates by specific rpoB mutations.
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Rifabutin and rifampin resistance levels and associated rpoB mutations in clinical isolates of Mycobacterium tuberculosis complex.
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Molecular characterization of multidrug-resistant Mycobacterium tuberculosis isolated from south-central in China.
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mutations in the rpoB gene are associated with rifampicin resistance
Correlation between genotypic and phenotypic testing for resistance to rifampin in Mycobacterium tuberculosis clinical isolates in Haiti: investigation of cases with discrepant susceptibility results.
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all mutations are in the rpoB gene
Profiling of rpoB mutations and MICs for rifampin and rifabutin in Mycobacterium tuberculosis.
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mutations in rpoB are associated with resistance to rifampin and rifabutin
Mechanisms of fitness cost reduction for rifampicin-resistant strains with deletion or duplication mutations in rpoB.
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A rapid, accurate, and low-cost method for detecting Mycobacterium tuberculosis and its drug-resistant genes in pulmonary tuberculosis: Applications of MassARRAY DNA mass spectrometry.
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Poor correlation with phenotype
Prevalence of Mycobacterium tuberculosis mutations associated with isoniazid and rifampicin resistance: A systematic review and meta-analysis.
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Molecular Analysis of Anti-Tuberculosis Drug Resistance of Mycobacterium tuberculosis Isolated in the Republic of Korea.
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Rapid Microarray-Based Detection of Rifampin, Isoniazid, and Fluoroquinolone Resistance in Mycobacterium tuberculosis by Use of a Single Cartridge.
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Mutations in rpoB, katG, and gyrA were analyzed for their association with resistance to rifampin, isoniazid, and fluoroquinolones.
Absence of hybridization with the wild-type and mutant rpoB probes in the Genotype MTBDRplus assay detects 'disputed' rifampicin mutations.
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Mutations in rpoB were identified in isolates that failed to hybridize to rpoB wild-type probes, and some of these mutations were 'disputed' as they did not consistently correlate with rifampicin resistance.
Genotypic drug resistance using whole-genome sequencing of Mycobacterium tuberculosis clinical isolates from North-western Tanzania.
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compensatory mutation in MDR-TB isolate
Mutations of rpoB, katG, inhA and ahp genes in rifampicin and isoniazid-resistant Mycobacterium tuberculosis in Kyrgyz Republic.
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Validation of the FluoroType MTBDR Assay for Detection of Rifampin and Isoniazid Resistance in Mycobacterium tuberculosis Complex Isolates.
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Prevalence and patterns of rifampicin and isoniazid resistance conferring mutations in Mycobacterium tuberculosis isolates from Uganda.
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Mutations in rpoB RRDR region associated with rifampicin resistance.
Frequency of genomic mutations mediating resistance of Mycobacterium tuberculosis isolates to rifampicin in Northern Morocco.
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Mutations in the rpoB gene were identified as the primary cause of rifampicin resistance in Mycobacterium tuberculosis isolates.
Interpretation of Discordant Rifampicin Susceptibility Test Results Obtained Using GeneXpert vs Phenotypic Drug Susceptibility Testing.
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mutations in the rifampin resistance-determining region of the rpoB gene
Compensatory evolution in rifampin-resistant Escherichia coli.
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rpoB
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