ResLit - Antimicrobial Resistance Gene & Mutation Database

a gene which contributes to membrane charge through lysinylation of PG

Protein ChangeG61V

Validation StatusConfirmed2+ DBs

Databases

Card DatabaseReference Gene CatalogReslit

Overview

Mechanism: gain-in-function, single resistance variant, bifunctional lysylphosphatidylglycerol flippase/synthetase MprF
Resistance To: daptomycin
Organisms: Staphylococcus aureus
Papers: 2

Paper Information2

Whole genome characterization of the mechanisms of daptomycin resistance in clinical and laboratory derived isolates of Staphylococcus aureus.

Research Article

Staphylococcus aureus mprF with mutation conferring resistance to daptomycin; CARD accession: CARD:3003319

Prevalence and Genetic Basis of Antimicrobial Resistance in Non-aureus Staphylococci Isolated from Canadian Dairy Herds.

Research Article

Residue substitutions in mprF associated with daptomycin resistance.

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