Browse AMR Mutations
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
Overview
Multiple rpoB mutants of Mycobacterium tuberculosis and second-order selection.
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Mutations in rpoB are associated with rifampin resistance in M. tuberculosis.
Cross-resistance of Escherichia coli RNA polymerases conferring rifampin resistance to different antibiotics.
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Mutations in the rpoB gene encoding the beta subunit of RNA polymerase confer resistance to rifampin and related antibiotics.
Detection of rpoB mutations associated with rifampin resistance in Mycobacterium tuberculosis using denaturing gradient gel electrophoresis.
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all mutations are in the rpoB gene and confer resistance to rifampin
Acquisition of rifabutin resistance by a rifampicin resistant mutant of Mycobacterium tuberculosis involves an unusual spectrum of mutations and elevated frequency.
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Mutations in the rpoB gene were identified through sequencing of gene fragments.
Emergence and molecular characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates from the Delhi Region in India.
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Previously reported
Rapid Detection of Multidrug-Resistant Mycobacterium tuberculosis by Use of Real-Time PCR and High-Resolution Melt Analysis.
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The beginning of the rpoB gene in addition to the rifampin resistance determination region might be needed for identifying rifampin/rifabutin cross-resistance in multidrug-resistant Mycobacterium tuberculosis isolates from Southern China.
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Rapid detection of rpoB mutations in rifampin resistant M. tuberculosis from sputum samples by denaturing gradient gel electrophoresis.
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mutations in rpoB gene associated with rifampin resistance
Genetic determinants of drug-resistant tuberculosis among HIV-infected patients in Nigeria.
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Sequence analysis of the rifampicin resistance determining region (RRDR) of rpoB gene in multidrug resistance confirmed and newly diagnosed tuberculosis patients of Punjab, Pakistan.
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mutations in rpoB gene associated with rifampicin resistance
Emergence and clonal transmission of multi-drug-resistant tuberculosis among patients in Chad.
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DNA Breaks-Mediated Fitness Cost Reveals RNase HI as a New Target for Selectively Eliminating Antibiotic-Resistant Bacteria.
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Rif R mutation
Dependence of Xpert MTB/RIF Accuracy for Detecting Rifampin Resistance in Bronchoalveolar Lavage Fluid on Bacterial Load: A Retrospective Study in Beijing, China.
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Mutations identified in rpoB gene associated with rifampicin resistance.
Antimicrobial Resistance in Mycobacterium tuberculosis Clinical Isolates from HIV-Positive and HIV-Negative Patients in Russia
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Mutations in the rpoB Gene of Rifampin-Resistant Mycobacterium tuberculosis Strains Isolated Mostly in Asian Countries and Their Rapid Detection by Line Probe Assay.
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Genetic antagonism and hypermutability in Mycobacterium smegmatis.
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reverted to wild type at high frequency
Rapid detection of rpoB gene mutations in rifampin-resistant Mycobacterium tuberculosis isolates in shanghai by using the amplification refractory mutation system.
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Genetic and phenotypic characterization of drug-resistant Mycobacterium tuberculosis isolates in Hong Kong.
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Detected in multiple isolates
Positive epistasis drives the acquisition of multidrug resistance.
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Selection of mutations to detect multidrug-resistant Mycobacterium tuberculosis strains in Shanghai, China.
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Use of the GenoType(R) MTBDRplus assay to assess drug resistance of Mycobacterium tuberculosis isolates from patients in rural Uganda.
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Rapid diagnosis of extensively drug-resistant tuberculosis by use of a reverse line blot hybridization assay.
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Study of Genetic Evolution in Mycobacterium tuberculosis Isolates from Patients with Active Pulmonary Tuberculosis in the Iran and Belarus.
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mutations in rpoB gene confer resistance to rifampicin
Mutation analysis of mycobacterial rpoB genes and rifampin resistance using recombinant Mycobacterium smegmatis.
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All mutations were experimentally validated in this study.
Visual detection of rpoB mutations in rifampin-resistant Mycobacterium tuberculosis strains by use of an asymmetrically split peroxidase DNAzyme.
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mutations in rpoB gene confer rifampin resistance
Drug-resistant tuberculosis in Central Mozambique: the role of a rapid genotypic susceptibility testing.
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Assessment of a 96-Well Plate Assay of Quantitative Drug Susceptibility Testing for Mycobacterium Tuberculosis Complex in China.
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Direct Detection of Rifampin and Isoniazid Resistance in Sputum Samples from Tuberculosis Patients by High-Resolution Melt Curve Analysis.
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Use of DNA microarray chips for the rapid detection of Mycobacterium tuberculosis resistance to rifampicin and isoniazid.
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Combination of commercially available molecular assays and culture based methods in diagnosis of tuberculosis and drug resistant tuberculosis.
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Among the five isolates that were resistant to RMP various mutations of the rpoB gene were detected. The types of mutations were similar to those found in a previous study from Greek patients affecting most commonly codons 531 and 526.
Plasmid-based high-resolution melting analysis for accurate detection of rpoB mutations in Mycobacterium tuberculosis isolates from Moroccan patients.
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Five rifampicin-resistant isolates lacked mutations in the rpoB amplified region.
Detection of mutations in the rpoB gene of rifampicin-resistant Mycobacterium tuberculosis strains inhibiting wild type probe hybridization in the MTBDR plus assay by DNA sequencing directly from clinical specimens.
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Mutations in the rpoB gene associated with rifampicin resistance
Genotypic Distribution and a Potential Diagnostic Assay of Multidrug-Resistant Tuberculosis in Northern Thailand.
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High-throughput method characterizes hundreds of previously unknown antibiotic resistance mutations.
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rpoB mutations were selected for by rifampicin
Molecular evidence for heterogeneity of the multiple-drug-resistant Mycobacterium tuberculosis population in Scotland (1990 to 1997).
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Mutations in rpoB are associated with rifampin resistance.
Physiological cost of rifampin resistance induced in vitro in Mycobacterium tuberculosis.
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Characterization of mutations in the rpoB gene associated with rifampin resistance in Rhodococcus equi isolated from foals.
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Mutations in the rpoB gene are associated with rifampin resistance in Rhodococcus equi.
New real-time PCR able to detect in a single tube multiple rifampin resistance mutations and high-level isoniazid resistance mutations in Mycobacterium tuberculosis.
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Mutations in rpoB gene associated with rifampin resistance
Emergence of rifampin-resistant Rhodococcus equi with several types of mutations in the rpoB gene among AIDS patients in northern Thailand.
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Novel mutation in R. equi
Effect of rpoB Mutations Conferring Rifampin Resistance on Fitness of Mycobacterium tuberculosis.
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Multidrug-resistant tuberculosis detection, Latvia.
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Mutations detected by line probe assay for rpoB gene.
Evaluation of the TB-Biochip oligonucleotide microarray system for rapid detection of rifampin resistance in Mycobacterium tuberculosis.
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Multidrug-resistant Mycobacterium tuberculosis, Bangui, Central African Republic.
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Mutations in rpoB are responsible for rifampin resistance.
Characterization of RPO B gene for detection of rifampicin drug resistance by SSCP and sequence analysis.
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Mutations in the rpoB gene were associated with rifampicin resistance.
Associations between Mycobacterium tuberculosis strains and phenotypes.
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Mutations in rpoB gene associated with rifampin resistance
High-resolution melting curve analysis for rapid detection of rifampin and isoniazid resistance in Mycobacterium tuberculosis clinical isolates.
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Mutations in rpoB gene are associated with rifampin resistance.
Use of multiplex allele-specific polymerase chain reaction (MAS-PCR) to detect multidrug-resistant tuberculosis in Panama.
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Detected in 53/67 isolates
Structural basis for rifamycin resistance of bacterial RNA polymerase by the three most clinically important RpoB mutations found in Mycobacterium tuberculosis.
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The wild-type rpoB gene is susceptible to rifampicin.
Multidrug-resistant bacteria compensate for the epistasis between resistances.
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Confers resistance to rifampicin
The New Xpert MTB/RIF Ultra: Improving Detection of Mycobacterium tuberculosis and Resistance to Rifampin in an Assay Suitable for Point-of-Care Testing.
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Mutations in rpoB were analyzed for their effect on rifampin resistance.
Dynamics of Extensive Drug Resistance Evolution of Mycobacterium tuberculosis in a Single Patient During 9 Years of Disease and Treatment.
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Extreme Antagonism Arising from Gene-Environment Interactions.
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Mutations in rpoB confer resistance to rifampicin
Analysing the fitness cost of antibiotic resistance to identify targets for combination antimicrobials.
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The H526Y mutation in rpoB was identified as a cause of rifampicin resistance.
Identification of echinoderm metabolites as potential inhibitors targeting wild-type and mutant forms of Escherichia coli RNA polymerase (RpoB) for tuberculosis treatment.
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Mutations in RpoB were analyzed for their impact on binding affinity of echinoderm metabolites.
Nanopore-based targeted next-generation sequencing (tNGS): A versatile technology specialized in detecting low bacterial load clinical specimens.
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All mutations were identified in the rpoB gene, with 20 located in the rifampicin resistance-determining region (RRDR) and one outside the RRDR.
Patterns of compensatory mutations in rpoA/B/C genes of multidrug resistant M. tuberculosis in Uganda.
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Mutations in rpoB are associated with rifampicin resistance.
Patterns of compensatory mutations in rpoA/B/C genes of multidrug resistant M. tuberculosis in Uganda.
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Some mutations are classified as low-level resistance-conferring.
A novel one-tube nested fluorescence melting curve analysis for rapid detection of drug-resistant Mycobacterium tuberculosis.
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All mutations were confirmed by DNA sequencing.
Assessment of the genotype MTBDRplus assay for rifampin and isoniazid resistance detection on sputum samples in Cote d'Ivoire.
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Defining multidrug-resistant tuberculosis: correlating GenoType MTBDRplus assay results with minimum inhibitory concentrations.
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mutations in the rpoB gene are associated with rifampicin resistance
Modified Proofreading PCR for Detection of Point Mutations, Insertions and Deletions Using a ddNTP-Blocked Primer.
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Detected in Mycobacterium tuberculosis
Comparative Evaluation of Sloppy Molecular Beacon and Dual-Labeled Probe Melting Temperature Assays to Identify Mutations in Mycobacterium tuberculosis Resulting in Rifampin, Fluoroquinolone and Aminoglycoside Resistance.
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The impact of drug resistance on Mycobacterium tuberculosis physiology: what can we learn from rifampicin?
Review
Mutations in rpoB are associated with rifampicin resistance in Mycobacterium tuberculosis.
Molecular analysis of rpoB gene mutations in rifampicin resistant Mycobacterium tuberculosis isolates by multiple allele specific polymerase chain reaction in Puducherry, South India.
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Mutations in the rpoB gene were associated with rifampicin resistance in Mycobacterium tuberculosis isolates.
Molecular profiling of drug resistant isolates of Mycobacterium tuberculosis in the state of Santa Catarina, southern Brazil.
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Mutations in rpoB are associated with rifampicin resistance.
Phenotypic and genotypic analysis of anti-tuberculosis drug resistance in Mycobacterium tuberculosis isolates in Myanmar.
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Whole genome sequencing reveals genomic heterogeneity and antibiotic purification in Mycobacterium tuberculosis isolates.
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Prevalence and molecular characteristics of drug-resistant Mycobacterium tuberculosis in Beijing, China: 2006 versus 2012.
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Rifampin Resistance Mutations Are Associated with Broad Chemical Remodeling of Mycobacterium tuberculosis.
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Molecular characterization of pre-extensive drug resistant Mycobacterium tuberculosis in Northeast Brazil.
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Dysbiosis individualizes the fitness effect of antibiotic resistance in the mammalian gut.
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Confers resistance to rifampicin
Patterns and profiles of drug resistance-conferring mutations in Mycobacterium tuberculosis genotypes isolated from tuberculosis-suspected attendees of spiritual holy water sites in Northwest Ethiopia.
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Most frequent mutation in RIF-resistant isolates
Transmission characteristics in Tuberculosis by WGS: nationwide cross-sectional surveillance in China.
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Mutations in rpoB were identified in MDR/RR-TB isolates.
Genotypic and phenotypic drug resistance patterns of Mycobacterium tuberculosis isolated from presumptive pulmonary tuberculosis patients in Ethiopia: A multicenter study.
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Predicting extensively drug-resistant Mycobacterium tuberculosis phenotypes with genetic mutations.
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Rifampicin mono-resistant tuberculosis in France: a 2005-2010 retrospective cohort analysis.
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Mutations identified in rpoB were associated with rifampicin resistance.
Correlation between genotypic and phenotypic testing for resistance to rifampin in Mycobacterium tuberculosis clinical isolates in Haiti: investigation of cases with discrepant susceptibility results.
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all mutations are in the rpoB gene
Comparison of Xpert MTB/RIF with line probe assay for detection of rifampin-monoresistant Mycobacterium tuberculosis.
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Pyrosequencing for rapid detection of tuberculosis resistance in clinical isolates and sputum samples from re-treatment pulmonary tuberculosis patients.
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Profiling of rpoB mutations and MICs for rifampin and rifabutin in Mycobacterium tuberculosis.
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mutations in rpoB are associated with resistance to rifampin and rifabutin
Mutations of rpob Gene Associated with Rifampin Resistance among Mycobacterium Tuberculosis Isolated in Tuberculosis Regional Reference Laboratory in Northeast of Iran during 2015-2016.
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Performance of an Xpert-based diagnostic algorithm for the rapid detection of drug-resistant tuberculosis among high-risk populations in a low-incidence setting.
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Phenotypic and genomic comparison of Photorhabdus luminescens subsp. laumondii TT01 and a widely used rifampicin-resistant Photorhabdus luminescens laboratory strain.
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Mutations in rpoB confer rifampicin resistance
Ultrasensitive Detection of Multidrug-Resistant Mycobacterium tuberculosis Using SuperSelective Primer-Based Real-Time PCR Assays.
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A rapid, accurate, and low-cost method for detecting Mycobacterium tuberculosis and its drug-resistant genes in pulmonary tuberculosis: Applications of MassARRAY DNA mass spectrometry.
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Poor correlation with phenotype
Epistasis decreases with increasing antibiotic pressure but not temperature.
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Mutations in rpoB confer resistance to rifampicin by altering the binding site.
Prevalence of Mycobacterium tuberculosis mutations associated with isoniazid and rifampicin resistance: A systematic review and meta-analysis.
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Using Microfluidic Chip and Allele-Specific PCR to Rapidly Identify Drug Resistance-Associated Mutations of Mycobacterium tuberculosis.
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Pervasive genotype-by-environment interactions shape the fitness effects of antibiotic resistance mutations.
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All mutations are in the rpoB gene, which encodes the beta subunit of RNA polymerase.
A preliminary evaluation of targeted nanopore sequencing technology for the detection of Mycobacterium tuberculosis in bronchoalveolar lavage fluid specimens.
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Drug susceptibility of Mycobacterium tuberculosis Beijing genotype and association with MDR TB.
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Mutations in rpoB were identified in rifampin-resistant mutants.
Resistance of Mycobacterium tuberculosis to antibiotics in Lao PDR: first multicentric study conducted in 3 hospitals.
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The H526Y mutation in rpoB is a known mutation associated with rifampicin resistance.
A simple, rapid and economic method for detecting multidrug-resistant tuberculosis.
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Detected in 80 isolates
Systematic review of allelic exchange experiments aimed at identifying mutations that confer drug resistance in Mycobacterium tuberculosis.
Review
Mutations in rpoB confer resistance to rifampicin
Correlation between the BACTEC MGIT 960 culture system with Genotype MTBDRplus and TB-SPRINT in multidrug resistant Mycobacterium tuberculosis clinical isolates from Brazil.
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Prevalence of rifampicin-resistant Mycobacterium tuberculosis among human-immunodeficiency-virus-seropositive patients and their treatment outcomes.
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Mutations in the rpoB gene were associated with rifampicin resistance.
Performance of MTBDRplus assay in detecting multidrug resistant tuberculosis at hospital level.
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Mutations in rpoB gene infer RIF resistance
Rapid Microarray-Based Detection of Rifampin, Isoniazid, and Fluoroquinolone Resistance in Mycobacterium tuberculosis by Use of a Single Cartridge.
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Mutations in rpoB, katG, and gyrA were analyzed for their association with resistance to rifampin, isoniazid, and fluoroquinolones.
Efflux Activity Differentially Modulates the Levels of Isoniazid and Rifampicin Resistance among Multidrug Resistant and Monoresistant Mycobacterium tuberculosis Strains.
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Mutations of rpoB, katG, inhA and ahp genes in rifampicin and isoniazid-resistant Mycobacterium tuberculosis in Kyrgyz Republic.
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Prevalence and patterns of rifampicin and isoniazid resistance conferring mutations in Mycobacterium tuberculosis isolates from Uganda.
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Mutations in rpoB RRDR region associated with rifampicin resistance.
Frequency of first and second-line drug resistance-associated mutations among resistant Mycobacterium tuberculosis clinical isolates from São Paulo, Brazil.
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Frequency of genomic mutations mediating resistance of Mycobacterium tuberculosis isolates to rifampicin in Northern Morocco.
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Mutations in the rpoB gene were identified as the primary cause of rifampicin resistance in Mycobacterium tuberculosis isolates.
Radial Expansion Facilitates the Maintenance of Double Antibiotic Resistances
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Molecular detection of multidrug resistance pattern and associated gene mutations in M. tuberculosis isolates from newly diagnosed pulmonary tuberculosis patients in Addis Ababa, Ethiopia.
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Mapping and sequencing of mutations in the Escherichia coli rpoB gene that lead to rifampicin resistance.
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Escherichia coli rpoB mutants conferring resistance to rifampicin; CARD accession: CARD:3003288
rpoB
Real-time PCR and high-resolution melt analysis for rapid detection of Mycobacterium leprae drug resistance mutations and strain types.
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Detected in clinical strains
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