Browse AMR Mutations
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
Overview
Use of applied biosystems 7900HT sequence detection system and Taqman assay for detection of quinolone-resistant Neisseria gonorrhoeae.
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associated with ciprofloxacin resistance
Cultivation of Neisseria gonorrhoeae in liquid media and determination of its in vitro susceptibilities to quinolones.
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Susceptibility Trends of Zoliflodacin against Multidrug-Resistant Neisseria gonorrhoeae Clinical Isolates in Nanjing, China, 2014 to 2018.
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Molecular Epidemiology, Antimicrobial Surveillance, and PK/PD Analysis to Guide the Treatment of Neisseria gonorrhoeae Infections.
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Mutations in the gyrA gene contribute to ciprofloxacin resistance.
The antimicrobial resistance landscape of Neisseria gonorrhoeae in New Zealand from November 2018 to March 2019 and the role of sexual orientation in transmission.
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Mutations in gyrA contribute to resistance to ciprofloxacin.
Evaluation of the Allplex NG & DR assay for molecular prediction of ciprofloxacin and azithromycin resistance in Neisseria gonorrhoeae.
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The S91F mutation in gyrA is associated with ciprofloxacin resistance.
Antimicrobial resistance of Neisseria gonorrhoeae and high prevalence of ciprofloxacin-resistant isolates in Japan, 1993 to 1998.
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Mutations in gyrA contribute to ciprofloxacin resistance in Neisseria gonorrhoeae
Molecular basis of high-level ciprofloxacin resistance in Neisseria gonorrhoeae strains isolated in Denmark from 1995 to 1998.
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Molecular characterization of Neisseria gonorrhoeae identifies transmission and resistance of one ciprofloxacin-resistant strain.
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Two nonsynonymous SNPs in the QRDR of the gyrA gene, Ser91 and Asp95.
Molecular epidemiology of drug-resistant Neisseria gonorrhoeae in Russia (Current Status, 2015).
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Neisseria gonorrhoeae gyrA with mutations conferring resistance to fluoroquinolones; CARD accession: CARD:3003928
In Vitro Activity of Gepotidacin (GSK2140944) against Neisseria gonorrhoeae.
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Mutation identified in isolate 12
WGS to predict antibiotic MICs for Neisseria gonorrhoeae.
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Exploration of the Neisseria Resistome Reveals Resistance Mechanisms in Commensals That May Be Acquired by N. gonorrhoeae through Horizontal Gene Transfer.
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Shanghai Neisseria gonorrhoeae Isolates Exhibit Resistance to Extended-Spectrum Cephalosporins and Clonal Distribution.
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GyrA substitutions S91F and D95A are associated with ciprofloxacin resistance.
Genomic surveillance of Neisseria gonorrhoeae in the Philippines, 2013-2014.
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First National Genomic Epidemiological Study of Neisseria gonorrhoeae Strains Spreading Across Sweden in 2016.
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Characterization of a Neisseria gonorrhoeae Ciprofloxacin panel for an antimicrobial resistant Isolate Bank.
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Mutation at position 272 (C272T) leading to S91F in gyrA
Correlation of in vitro susceptibilities to newer quinolones of naturally occurring quinolone-resistant Neisseria gonorrhoeae strains with changes in GyrA and ParC.
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Comparison of mismatch amplification mutation assay with DNA sequencing for characterization of fluoroquinolone resistance in Neisseria gonorrhoeae.
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Mutations in gyrA are associated with fluoroquinolone resistance in N. gonorrhoeae.
Detection of gyrA and parC mutations associated with ciprofloxacin resistance in Neisseria gonorrhoeae by use of oligonucleotide biochip technology.
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Disseminated gonococcal infection in an immunocompetent patient caused by an imported Neisseria gonorrhoeae multidrug-resistant strain.
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Distinguishing importation from diversification of quinolone-resistant Neisseria gonorrhoeae by molecular evolutionary analysis.
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Mutations in gyrA and parC were identified as determinants of quinolone resistance.
Relation between genetic markers of drug resistance and susceptibility profile of clinical Neisseria gonorrhoeae strains.
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High prevalence of mutations in quinolone-resistance-determining regions and mtrR loci in polyclonal Neisseria gonorrhoeae isolates at a tertiary hospital in Southern Taiwan.
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Mutations in gyrA were associated with ciprofloxacin resistance.
Reflex Detection of Ciprofloxacin Resistance in Neisseria gonorrhoeae by Use of the SpeeDx ResistancePlus GC Assay.
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Wild-type gyrA is susceptible to ciprofloxacin
Molecular characterization of a ceftriaxone-resistant Neisseria gonorrhoeae strain found in Switzerland: a case report.
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Antimicrobial Resistance Profiling and Phylogenetic Analysis of Neisseria gonorrhoeae Clinical Isolates From Kenya in a Resource-Limited Setting.
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Mutations in GyrA disrupt hydrogen bonding with ciprofloxacin.
Hydrogel Droplet Microarray for Genotyping Antimicrobial Resistance Determinants in Neisseria gonorrhoeae Isolates.
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Neisseria gonorrhoeae FC428 Subclone, Vietnam, 2019-2020.
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associated with ciprofloxacin resistance
Susceptibility of Neisseria gonorrhoeae to Zoliflodacin and Quinolones in Hyogo Prefecture, Japan.
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associated with high non-susceptibility to quinolones
Inhibition of Neisseria gonorrhoeae Type II Topoisomerases by the Novel Spiropyrimidinetrione AZD0914.
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Mutation S91F in GyrA confers resistance to fluoroquinolones.
Summary and Trends of the Russian Gonococcal Antimicrobial Surveillance Programme, 2005 to 2016.
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Improved determination of Neisseria gonorrhoeae gyrase A genotype results in clinical specimens.
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The study focuses on the detection of gyrA mutations, particularly at codon 91, which is associated with ciprofloxacin resistance.
Genotypic and Phenotypic Characterization of Antimicrobial Resistance in Neisseria gonorrhoeae: a Cross-Sectional Study of Isolates Recovered from Routine Urine Cultures in a High-Incidence Setting.
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Temporal evolution of antimicrobial resistance among Neisseria gonorrhoeae clinical isolates in the most populated South American Metropolitan Region.
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Antimicrobial resistance genetic factor identification from whole-genome sequence data using deep feature selection.
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Genomic evolution of Neisseria gonorrhoeae since the preantibiotic era (1928-2013): antimicrobial use/misuse selects for resistance and drives evolution.
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Antimicrobial resistance and heterogeneity of Neisseria gonorrhoeae isolated from patients attending sexually transmitted infection clinics in Lusaka, Zambia.
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Target enrichment improves culture-independent detection of Neisseria gonorrhoeae and antimicrobial resistance determinants direct from clinical samples with Nanopore sequencing.
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Target-Mediated Fluoroquinolone Resistance in Neisseria gonorrhoeae: Actions of Ciprofloxacin against Gyrase and Topoisomerase IV.
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Drift in susceptibility of Neisseria gonorrhoeae to ciprofloxacin and emergence of therapeutic failure.
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Molecular basis of high-level ciprofloxacin resistance in Neisseria gonorrhoeae strains from Shandong Province, China.
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Gonorrhoea treatment failure caused by a Neisseria gonorrhoeae strain with combined ceftriaxone and high-level azithromycin resistance, England, February 2018.
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The isolate had the S91F and D95A mutations in gyrA, reducing quinolone binding to DNA gyrase.
Whole-Genome Sequencing of Russian Neisseria Gonorrhoeae Isolates Related to ST 1407 Genogroup.
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Multidrug-resistant Neisseria gonorrhoeae isolate, belonging to the internationally spreading Japanese FC428 clone, with ceftriaxone resistance and intermediate resistance to azithromycin, Ireland, August 2018.
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causes high-level resistance to ciprofloxacin
Genome-wide discovery of epistatic loci affecting antibiotic resistance in Neisseria gonorrhoeae using evolutionary couplings.
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Known resistance locus
Antimicrobial resistance prediction and phylogenetic analysis of Neisseria gonorrhoeae isolates using the Oxford Nanopore MinION sequencer.
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Mutation in gyrA leads to resistance to ciprofloxacin.
Detection in the United Kingdom of the Neisseria gonorrhoeae FC428 clone, with ceftriaxone resistance and intermediate resistance to azithromycin, October to December 2018.
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gyrA and parC mutations in fluoroquinolone-resistant Neisseria gonorrhoeae isolates from Kenya.
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Assessment of Antibiotic Resistance and Efflux Pump Gene Expression in Neisseria Gonorrhoeae Isolates from South Africa by Quantitative Real-Time PCR and Regression Analysis.
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associated with decreased expression
Current Susceptibility Surveillance and Distribution of Antimicrobial Resistance in N. gonorrheae within WHO Regions.
Review
gyrA mutations are associated with resistance to fluoroquinolones.
Extra-genital Neisseria gonorrhoeae infections with genetic mutations conferring ciprofloxacin resistance among men who have sex with men and transgender women in Lima, Peru.
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Mutation at codon Ser91 of the gyrA gene confers ciprofloxacin resistance.
Pre-exposure to azithromycin enhances gonococcal resilience to subsequent ciprofloxacin exposure: an in vitro study.
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Mutation observed in lineages exposed to GC broth followed by ciprofloxacin.
Genomic analysis of 1710 surveillance-based Neisseria gonorrhoeae isolates from the USA in 2019 identifies predominant strain types and chromosomal antimicrobial-resistance determinants.
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Dissemination of Neisseria gonorrhoeae with decreased susceptibility to extended-spectrum cephalosporins in Southern China, 2021: a genome-wide surveillance from 20 cities.
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Antimicrobial susceptibilities and genomic epidemiology of Neisseria gonorrhoeae in Stockholm, Sweden.
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Whole genome analysis and antimicrobial resistance of Neisseria gonorrhoeae isolates from Ghana.
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Mutations in gyrA were linked to fluoroquinolone resistance.
Phenotypic and genotypic characterization of Neisseria gonorrhoeae isolates from Yaoundé, Cameroon, 2019 to 2020.
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Prevalence of mutations associated with macrolide and fluoroquinolone resistance in Neisseria gonorrhoeae with Allplex NG-DR Assay (Seegene) in a tertiary hospital from Madrid, Spain.
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Detected in 67 (59.8%) strains of NG.
Antimicrobial susceptibility and genetic characteristics of Neisseria gonorrhoeae isolates from India, Pakistan and Bhutan in 2007-2011.
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Mutations in the gyrA gene contribute to resistance to ciprofloxacin.
Antimicrobial resistance in Neisseria gonorrhoeae in the 21st century: past, evolution, and future.
Review
Results in resistance to ciprofloxacin.
Genomic epidemiology and antimicrobial resistance of Neisseria gonorrhoeae in New Zealand.
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Exploring quinolone resistance-determining region in Neisseria gonorrhoeae isolates from across India.
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Whole-genome sequencing reveals transmission of gonococcal antibiotic resistance among men who have sex with men: an observational study.
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Cephalosporin-Resistant Neisseria gonorrhoeae Clone, China
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Public health surveillance of multidrug-resistant clones of Neisseria gonorrhoeae in Europe: a genomic survey.
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associated with ciprofloxacin resistance
Horizontal Gene Transfer of Fluoroquinolone Resistance-Conferring Genes From Commensal Neisseria to Neisseria gonorrhoeae: A Global Phylogenetic Analysis of 20,047 Isolates.
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Substitution S91F in gyrA was associated with high-level resistance to ciprofloxacin.
Extensively drug-resistant (XDR) Neisseria gonorrhoeae causing possible gonorrhoea treatment failure with ceftriaxone plus azithromycin in Austria, April 2022.
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The novel 2024 WHO Neisseria gonorrhoeae reference strains for global quality assurance of laboratory investigations and superseded WHO N. gonorrhoeae reference strains-phenotypic, genetic and reference genome characterization.
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carried various mutations leading to fluoroquinolone resistance
Interactions between Zoliflodacin and Neisseria gonorrhoeae Gyrase and Topoisomerase IV: Enzymological Basis for Cellular Targeting.
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Mutations in gyrA increase susceptibility to zoliflodacin.
Emergence of Extensively Drug-Resistant Neisseria gonorrhoeae, France, 2023.
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Mutations in gyrA, gyrB, parC, and parE in quinolone-resistant strains of Neisseria gonorrhoeae.
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Mutation often seen together with D95N/G mutation (PMID: 23347339)
Neisseria gonorrhoeae acquires mutations in analogous regions of gyrA and parC in fluoroquinolone-resistant isolates.
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gyrA
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