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© 2026 ResLit. Data sourced from PubMed literature analysis.

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Browse Mutations rpoBS442Y

GenerpoB

Protein ChangeS442Y

Nucleotide ChangeC1325A

Validation StatusConfirmed2+ DBs

Databases

Reference Gene CatalogReslit

Overview

Mechanism: The mutation causes a serine to tyrosine substitution at position 442, leading to a more hydrophobic environment in the rifampin binding pocket, which reduces the effectiveness of rifampin., DNA-directed RNA polymerase subunit beta RpoB
Resistance To: Rifampin, RIFAMYCIN
Organisms: Streptomyces albus, Corynebacterium diphtheriae
Papers: 2

Paper Information2

1

Innovative approach for improvement of an antibiotic-overproducing industrial strain of Streptomyces albus.

PMID 14602594 · 2003

The rpoB mutations may affect antibiotic production by altering the initiation of secondary metabolism.

Mutation Information

rpoB: p.S442Y / c.C1325A

Protein Change: S442Y
Nucleotide Change: C1325A
Organisms: Streptomyces albus

ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

Confers Resistance To

Rifampin

Source Database

Reslit

2

Infection by a multidrug-resistant Corynebacterium diphtheriae strain: prediction of virulence factors, CRISPR-Cas system analysis, and structural implications of mutations conferring rifampin resistance.

PMID 39196424 · 2024

Mutation in rpoB gene causes rifampin resistance

Mutation Information

Protein Change: S442Y
Organisms: Corynebacterium diphtheriae
Confers Resistance To: Rifampin
Effect on Function: The mutation causes a serine to tyrosine substitution at position 442, leading to a more hydrophobic environment in the rifampin binding pocket, which reduces the effectiveness of rifampin.
Source Database: Reslit

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© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research