Browse AMR Mutations
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
Overview
In vitro selection of resistance to clinafloxacin, ciprofloxacin, and trovafloxacin in Streptococcus pneumoniae.
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Activities of clinafloxacin, gatifloxacin, gemifloxacin, and trovafloxacin against recent clinical isolates of levofloxacin-resistant Streptococcus pneumoniae.
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Genetic relatedness of levofloxacin-nonsusceptible Streptococcus pneumoniae isolates from North America.
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Mutant prevention concentrations for single-step fluoroquinolone-resistant mutants of wild-type, efflux-positive, or ParC or GyrA mutation-containing Streptococcus pneumoniae isolates.
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Horizontal transfer of fluoroquinolone resistance genes in Streptococcus pneumoniae
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Mutations in gyrA are associated with fluoroquinolone resistance.
In vitro activity of DC-159a, a new broad-spectrum fluoroquinolone, compared with that of other agents against drug-susceptible and -resistant pneumococci.
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Mutation detected in quinolone-resistant strains
Comparative study of the mutant prevention concentrations of moxifloxacin, levofloxacin, and gemifloxacin against pneumococci.
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mutations in quinolone resistance-determining region associated with resistance to fluoroquinolones
In vitro antibacterial activities of JNJ-Q2, a new broad-spectrum fluoroquinolone.
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Rapid pneumococcal evolution in response to clinical interventions.
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Clonal spread of levofloxacin-resistant streptococcus pneumoniae invasive isolates in Madrid, Spain, 2007 to 2009.
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Present in 21 isolates
Antibiotic resistance and population structure of Staphylococcus epidermidis from prosthetic joint infections in Sweden and France.
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Engineering the specificity of antibacterial fluoroquinolones: benzenesulfonamide modifications at C-7 of ciprofloxacin change its primary target in Streptococcus pneumoniae from topoisomerase IV to gyrase.
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Mutation in gyrA confers resistance to fluoroquinolones in S. pneumoniae.
Sub-inhibitory concentrations of vancomycin prevent quinolone-resistance in a penicillin-resistant isolate of Streptococcus pneumoniae.
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Mechanism of fluoroquinolone resistance is an important factor in determining the antimicrobial effect of gemifloxacin against Streptococcus pneumoniae in an in vitro pharmacokinetic model.
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Antimicrobial susceptibility and serotype distribution of Streptococcus pneumoniae and molecular characterization of multidrug-resistant serotype 19F, 6B, and 23F Pneumococci in northern Thailand.
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Mutation in gyrA gene associated with ciprofloxacin resistance.
Levofloxacin-resistant invasive Streptococcus pneumoniae in the United States: evidence for clonal spread and the impact of conjugate pneumococcal vaccine.
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Nonmolecular test for detection of low-level resistance to fluoroquinolones in Streptococcus pneumoniae.
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Molecular characterization of increasing fluoroquinolone resistance in Streptococcus pneumoniae isolates in Canada, 1997 to 2005.
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Molecular characterization of emerging non-levofloxacin-susceptible pneumococci isolated from children in South Africa.
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Fluoroquinolone Resistance in Streptococcus dysgalactiae subsp. equisimilis and Evidence for a Shared Global Gene Pool with Streptococcus pyogenes.
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High Prevalence of Macrolide-resistance and Molecular Characterization of Streptococcus pyogenes Isolates Circulating in China from 2009 to 2016.
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Population and Whole Genome Sequence Based Characterization of Invasive Group A Streptococci Recovered in the United States during 2015.
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Features of Streptococcus agalactiae strains recovered from pregnant women and newborns attending different hospitals in Ethiopia.
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Update on the Mechanisms of Antibiotic Resistance and the Mobile Resistome in the Emerging Zoonotic Pathogen Streptococcus suis.
Review
Contributions of the 8-Methoxy Group of Gatifloxacin to Resistance Selectivity, Target Preference, and Antibacterial Activity against Streptococcus pneumoniae.
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Genetic analyses of mutations contributing to fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae.
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In vitro activities of novel nonfluorinated quinolones PGE 9262932 and PGE 9509924 against clinical isolates of Staphylococcus aureus and Streptococcus pneumoniae with defined mutations in DNA gyrase and topoisomerase IV.
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Mutations in gyrA are associated with quinolone resistance.
Activities of mutant prevention concentration-targeted moxifloxacin and levofloxacin against Streptococcus pneumoniae in an in vitro pharmacodynamic model.
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Ciprofloxacin Dimers Target Gyrase in Streptococcus pneumoniae.
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Mutation in gyrA confers resistance to ciprofloxacin dimers and ciprofloxacin.
Fluoroquinolone and other antimicrobial resistance in invasive pneumococci, Hong Kong, 1995-2001.
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Mutations in gyrA contribute to fluoroquinolone resistance.
Prevalence and molecular analysis of macrolide and fluoroquinolone resistance among isolates of Streptococcus pneumoniae collected during the 2000-2001 PROTEKT US Study.
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Relative fitness of fluoroquinolone-resistant Streptococcus pneumoniae.
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The Anti-Methicillin-Resistant Staphylococcus aureus Quinolone WCK 771 Has Potent Activity against Sequentially Selected Mutants, Has a Narrow Mutant Selection Window against Quinolone-Resistant Staphylococcus aureus, and Preferentially Targets DNA Gyrase
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Mutations in gyrA confer resistance to WCK 771 and other quinolones.
Fitness costs of fluoroquinolone resistance in Streptococcus pneumoniae.
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Pneumococci can persistently colonize adult patients with chronic respiratory disease.
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Novel Levofloxacin-Resistant Multidrug-Resistant Streptococcus pneumoniae Serotype 11A Isolates, South Korea.
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Molecular characterization of fluoroquinolone resistance in invasive clinical isolates of Streptococcus pneumoniae susceptible to delafloxacin.
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Mutations in gyrA are associated with fluoroquinolone resistance
Fluoroquinolone-resistant pneumococci: dynamics of serotypes and clones in Spain in 2012 compared with those from 2002 and 2006.
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Efflux-mediated resistance identified among norfloxacin resistant clinical strains of group B Streptococcus from South Korea.
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Mutations in gyrA were associated with fluoroquinolone resistance.
Spread of Streptococcus pneumoniae serotype 8-ST63 multidrug-resistant recombinant Clone, Spain.
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Capsule Switching and Antimicrobial Resistance Acquired during Repeated Streptococcus pneumoniae Pneumonia Episodes.
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Serotype Changes and Drug Resistance in Invasive Pneumococcal Diseases in Adults after Vaccinations in Children, Japan, 2010-2013.
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Ser81Phe substitution in GyrA
Reactive Oxygen Species Contribute to the Bactericidal Effects of the Fluoroquinolone Moxifloxacin in Streptococcus pneumoniae.
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Mutation in gyrA (S81F) was identified in strain T2, which shows increased resistance to moxifloxacin.
Invasive Streptococcus suis isolated in Spain contain a highly promiscuous and dynamic resistome.
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associated with fluoroquinolone resistance
Resistome, mobilome, and virulome explored in clinical isolates derived from acne patients in Egypt: unveiling unique traits of an emerging coagulase-negative Staphylococcus pathogen.
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Sparfloxacin resistance in clinical isolates of Streptococcus pneumoniae: involvement of multiple mutations in gyrA and parC genes.
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Fluoroquinolone resistance mutations in the parC, parE, and gyrA genes of clinical isolates of viridans group streptococci.
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Mutations in gyrA transformed S. pneumoniae only when mutations in parC were present
Persistence and complex evolution of fluoroquinolone-resistant Streptococcus pneumoniae clone.
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Genomic Analysis Reveals New Integrative Conjugal Elements and Transposons in GBS Conferring Antimicrobial Resistance.
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Recombination-mediated dissemination of Methicillin-resistant S. aureus clonal complex 1 in the Egyptian health care settings.
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associated with CC8 and CC361 isolates
Molecular Analysis of Rising Fluoroquinolone Resistance in Belgian Non-Invasive Streptococcus pneumoniae Isolates (1995-2014).
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Allele-specific collateral and fitness effects determine the dynamics of fluoroquinolone resistance evolution.
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Mutations in gyrA contribute to fluoroquinolone resistance in S. pneumoniae.
Distinct impact of antibiotics on the gut microbiome and resistome: a longitudinal multicenter cohort study.
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Detected in one patient (ID 512) under ciprofloxacin treatment.
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