ResLit - Antimicrobial Resistance Gene & Mutation Database

GeneciaH

histidine kinase sensor

Protein ChangeT230P

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: activates the CiaRH system
Resistance To: Cefotaxime
Organisms: Streptococcus pneumoniae
Papers: 1

Paper Information1

The CiaRH system of Streptococcus pneumoniae prevents lysis during stress induced by treatment with cell wall inhibitors and by mutations in pbp2x involved in beta-lactam resistance.

PMID 16484208 · 2006

The T230→P mutation in ciaH activates the CiaRH system, leading to resistance to cefotaxime.

Mutation Information

ciaH: p.T230P

Protein Change: T230P
Organisms: Streptococcus pneumoniae
Confers Resistance To

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Mutation Information