Browse AMR Mutations
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
Overview
Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes clinical isolates with alterations in GyrA and ParC proteins.
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mutations in gyrA are associated with fluoroquinolone resistance
Development and validation of a diagnostic DNA microarray to detect quinolone-resistant Escherichia coli among clinical isolates.
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Single nucleotide exchange at position 83
Antimicrobial resistance types and genes in Salmonella enterica infantis isolates from retail raw chicken meat and broiler chickens on farms.
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Mutations in the quinolone resistance-determining region of gyrA contribute to nalidixic acid resistance.
Quinolone Resistance of Salmonella enterica Serovar Virchow Isolates from Humans and Poultry in Israel: Evidence for Clonal Expansion.
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The Asp87Tyr substitution was observed in all resistant isolates.
Multiple regulatory pathways associated with high-level ciprofloxacin and multidrug resistance in Salmonella enterica serovar enteritidis: involvement of ramA and other global regulators.
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Single mutation in all high-level nalidixic acid-resistant strains.
Multidrug-resistant Salmonella enterica serovar Infantis, Israel.
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associated with nalidixic acid resistance
A Multifactorial Approach for Surveillance of Shigella spp. and Entero-Invasive Escherichia coli Is Important for Detecting (Inter)national Clusters.
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Shared and Unique Evolutionary Trajectories to Ciprofloxacin Resistance in Gram-Negative Bacterial Pathogens.
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Mutations in gyrA are responsible for ciprofloxacin resistance in E. coli, A. baumannii, and P. aeruginosa.
Genomic surveillance of Pseudomonas aeruginosa in the Philippines, 2013-2014.
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Multidrug Resistance Dynamics in Salmonella in Food Animals in the United States: An Analysis of Genomes from Public Databases.
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Mutational Diversity in the Quinolone Resistance-Determining Regions of Type-II Topoisomerases of Salmonella Serovars.
Review
Common mutation in S. Typhi and other Salmonella serovars.
Mutations in gyrA are common in quinolone-resistant Salmonella isolates.
Genome and antibiotic resistance characteristics of Shigella clinical isolates in Fujian Province, Southeast China, 2005-2019.
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Mutations in gyrA and parC contribute to quinolone resistance.
Detection of antimicrobial resistance in Glaesserella parasuis in South China using whole-genome sequencing.
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Molecular epidemiology of Salmonella Enteritidis in humans and animals in Spain.
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associated with quinolone resistance
A global atlas and drivers of antimicrobial resistance in Salmonella during 1900-2023.
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Unveiling the Genetic Diversity and Antimicrobial Resistance Profiles of Salmonella Population From 2016 to 2020 in Thai Canal Water.
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Double amino acid substitutions in both positions of GyrA (S83F, D87N) and ParC (T57S, S80I) were observed in only S. Kentucky ST198 strains.
Antimicrobial resistance and plasmid-associated virulence genes in Salmonella isolated from pigs, pork, and humans in border provinces of Thailand and neighboring countries.
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Mutation in the quinolone resistance-determining region of gyrA leads to resistance to nalidixic acid.
Prevalence and genetic basis of extended-spectrum β-lactamase-producing Escherichia coli carriage in broiler farms in the United Arab Emirates.
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Detection of Decreased Fluoroquinolone Susceptibility in Salmonellas and Validation of Nalidixic Acid Screening Test
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Use of a LightCycler gyrA mutation assay for rapid identification of mutations conferring decreased susceptibility to ciprofloxacin in multiresistant Salmonella enterica serotype Typhimurium DT104 isolates.
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Mutations in gyrA confer decreased susceptibility to ciprofloxacin in multiresistant Salmonella enterica serotype Typhimurium DT104 isolates.
Alterations in DNA gyrase and topoisomerase IV in resistant mutants of Clostridium perfringens found after in vitro treatment with fluoroquinolones.
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Clonal Expansion May Account for High Levels of Quinolone Resistance in Salmonella enterica Serovar Enteritidis
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The G259T mutation in the gyrA gene was responsible for nalidixic acid resistance in most isolates.
Ciprofloxacin-resistant Salmonella Kentucky in travelers.
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Mutations in gyrA lead to ciprofloxacin resistance.
High-level fluoroquinolone resistance in ophthalmic clinical isolates belonging to the species Corynebacterium macginleyi.
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Mutations in the QRDRs of the gyrA gene were responsible for fluoroquinolone resistance in Corynebacterium macginleyi.
Novel approach for comparing the abilities of quinolones to restrict the emergence of resistant mutants during quinolone exposure.
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Mutations in gyrA were identified as key determinants of quinolone resistance in E. coli.
Multilocus variable-number tandem-repeat analysis, pulsed-field gel electrophoresis, and antimicrobial susceptibility patterns in discrimination of sporadic and outbreak-related strains of Yersinia enterocolitica.
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Mutations in gyrA were associated with resistance to nalidixic acid and reduced susceptibility to ciprofloxacin.
Differential epigenetic compatibility of qnr antibiotic resistance determinants with the chromosome of Escherichia coli.
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This mutation was found in strains MBS230 and MBS231, which evolved under alternating selective pressure from carbenicillin and ofloxacin.
Prevalence of plasmid-mediated quinolone resistance in Escherichia coli isolated from diseased animals in Taiwan.
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Antimicrobial Resistance of Salmonella enterica Serovar Typhimurium in Shanghai, China.
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Mutations in gyrA and parC genes contribute to ciprofloxacin resistance.
Evolution of Antibiotic Resistance in Surrogates of Francisella tularensis (LVS and Francisella novicida): Effects on Biofilm Formation and Fitness.
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Mutations in gyrA are associated with ciprofloxacin resistance.
A Multidrug-Resistant Salmonella Infantis Clone is Spreading and Recombining in the United States.
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mutation in gyrA confers fluoroquinolone resistance
Prevalence and Characterization of Quinolone-Resistance Determinants in Escherichia coli Isolated from Food-Producing Animals and Animal-Derived Food in the Philippines.
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The genomic epidemiology of multi-drug resistant invasive non-typhoidal Salmonella in selected sub-Saharan African countries.
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Mutations in gyrA confer resistance to fluoroquinolones.
Genomic Epidemiology of Multidrug-Resistant Nontyphoidal Salmonella in Young Children Hospitalized for Gastroenteritis.
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Multiple Novel Traits without Immediate Benefits Originate in Bacteria Evolving on Single Antibiotics.
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Mutations in gyrA confer resistance to quinolone antibiotics.
Genomic diversity of antimicrobial resistance in non-typhoidal Salmonella in Victoria, Australia.
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Antimicrobial susceptibility and virulence gene analysis of Shigella species causing dysentery in Iranian children: Implications for fluroquinolone resistance.
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Most common mutation in Shigella isolates
Molecular Characterization of Multidrug-Resistant Escherichia coli from Fecal Samples of Wild Animals.
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Retrospective analysis of antimicrobial resistance associated with bovine respiratory disease.
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Ribosome Phenotypes Can Be Used to Classify Ciprofloxacin-Resistant Clinical E. coli Isolates
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Mutation in gyrA leads to ciprofloxacin resistance
Stool carriage of CTX-M/CMY-producing Salmonella enterica in a Chinese tertiary hospital in Shenzhen, China.
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Comparative genomic analysis of Flavobacterium species causing columnaris disease of freshwater fish in Thailand: insights into virulence and resistance mechanisms.
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Mutations in gyrA were associated with decreased susceptibility to quinolones and fluoroquinolones.
Mechanisms of fluoroquinolone resistance among Escherichia coli isolates from urinary tract infections in Thailand.
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Genomic insights into antibiotic-resistant non-typhoidal Salmonella isolates from outpatients in Minhang District in Shanghai.
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Molecular Characteristics of Epidemiologically Successful Salmonella Enteritidis in Poland.
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Global genomic survey of Salmonella Kentucky: discovery of a chromosomeborne bla(NDM-5) and the emergence of ST314, an MDR clone mediated by the IncR plasmid.
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Gatifloxacin activity against quinolone-resistant gyrase: allele-specific enhancement of bacteriostatic and bactericidal activities by the C-8-methoxy group.
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Multidrug resistance in Salmonella enterica serotype Typhimurium from humans in France (1993 to 2003).
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Fitness costs and stability of a high-level ciprofloxacin resistance phenotype in Salmonella enterica serotype enteritidis: reduced infectivity associated with decreased expression of Salmonella pathogenicity island 1 genes.
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Increased survival of antibiotic-resistant Escherichia coli inside macrophages.
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The mutation was found to confer resistance to nalidixic acid.
Whole-Genome Sequencing of Drug-Resistant Salmonella enterica Isolates from Dairy Cattle and Humans in New York and Washington States Reveals Source and Geographic Associations.
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Mutations in gyrA are associated with quinolone resistance.
Time-Resolved Tracking of Mutations Reveals Diverse Allele Dynamics during Escherichia coli Antimicrobial Adaptive Evolution to Single Drugs and Drug Pairs.
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Epidemic characterization and molecular genotyping of Shigella flexneri isolated from calves with diarrhea in Northwest China.
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Mutations in gyrA and parC contribute to fluoroquinolone resistance.
Phylogenetic and Evolutionary Analysis Reveals the Recent Dominance of Ciprofloxacin-Resistant Shigella sonnei and Local Persistence of S. flexneri Clones in India.
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Mutations in gyr A contribute to fluoroquinolone resistance.
Selection of Resistant Bacteria in Mallards Exposed to Subinhibitory Concentrations of Ciprofloxacin in Their Water Environment.
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Both mutations were shown to confer resistance to ciprofloxacin in the study.
Molecular characterization of fluoroquinolone-resistant Escherichia coli from broiler breeder farms.
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Mutations in gyrA are associated with high-level fluoroquinolone resistance.
Emergence of mcr-1-Harboring Salmonella enterica Serovar Sinstorf Type ST155 Isolated From Patients With Diarrhea in Jiangsu, China.
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Mutations in gyrA contribute to ciprofloxacin resistance.
Extensive Drug-Resistant Salmonella enterica Isolated From Poultry and Humans: Prevalence and Molecular Determinants Behind the Co-resistance to Ciprofloxacin and Tigecycline.
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Mutations in gyrA gene were detected at codon S83 or D87 or both in 89.66% of XDR Salmonella.
Research note: The resistome of commensal Escherichia coli isolated from broiler carcasses "produced without the use of antibiotics"(a).
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Global population structure of the Serratia marcescens complex and identification of hospital-adapted lineages in the complex.
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Characterisation of Salmonella Enteritidis ST11 and ST1925 Associated with Human Intestinal and Extra-Intestinal Infections in Singapore.
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Mutational Switch-Backs Can Accelerate Evolution of Francisella to a Combination of Ciprofloxacin and Doxycycline.
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Genomic perspective on the bacillus causing paratyphoid B fever.
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Mutations in quinolone resistance-determining regions of gyrA and gyrB
Targeting efflux pumps prevents the multi-step evolution of high-level resistance to fluoroquinolone in Pseudomonas aeruginosa.
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Prevalence and characterization of ciprofloxacin-resistant Salmonella enterica spp. isolated from food animals during 2010-2023 in South Korea.
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Genomic analyses reveal presence of extensively drug-resistant Salmonella enterica serovars isolated from clinical samples in Guizhou province, China, 2019-2023.
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Mutations in quinolone resistance-determining regions (QRDRs)
Exploring the potential role of GyrA inhibiting quinoline analog: an in silico study.
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All mutations are in the quinolone resistance-determining region (QRDR) of gyrA.
Plasmid-driven clonal expansion of multidrug-resistant monophasic Salmonella Typhimurium in a Global Food Trade Hub.
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Genomic evolution of Salmonella Dublin in cattle and humans in the United States.
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The effect of commonly used non-antibiotic medications on antimicrobial resistance development in Escherichia coli.
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Mutations in GyrA are associated with fluoroquinolone resistance, leading to reduced susceptibility to ciprofloxacin.
Mutations in gyrA, such as S83L and D87G, reduce susceptibility to fluoroquinolones, contributing to ciprofloxacin resistance.
Characteristics of quinolone resistance in Escherichia coli isolated from wildlife in Poland.
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Mutations in QRDR region are associated with high MIC values
Genomic and epidemiological characteristics of Shigella boydii in Australia, 1991-2022.
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A contemporary genomic snapshot of Salmonella Paratyphi A in Pakistan.
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Multiple point mutations in gyrA were identified, contributing to ciprofloxacin resistance.
Molecular characterization of mcr-1.1-harboring multidrug-resistant Escherichia coli isolates from chicken in the United Arab Emirates: implications for one health surveillance.
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Mutations in gyrA contribute to fluoroquinolone resistance
Structure based in silico analysis of quinolone resistance in clinical isolates of Salmonella Typhi from India.
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Mutations in the QRDR of gyrA are responsible for quinolone resistance in S. Typhi.
Mutations in DNA Gyrase alter the characteristics of the binding pocket resulting in the loss of crucial molecular interactions and consequently decrease the binding affinity of fluoroquinolones with the target protein.
Informal genomic surveillance of regional distribution of Salmonella Typhi genotypes and antimicrobial resistance via returning travellers.
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Mutations in the quinolone resistance determining region (QRDR) of gyrA and parC are associated with reduced susceptibility to fluoroquinolones.
Ciprofloxacin-Resistant Salmonella enterica Serovar Kentucky ST198 in Broiler Chicken Supply Chain and Patients, China, 2010-2016.
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Mutations in gyrA contribute to nalidixic acid resistance.
Genetic Diversity of Salmonella enterica subsp. enterica Serovar Enteritidis from Human and Non-Human Sources in Portugal.
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Antimicrobial resistance and population genomics of emerging multidrug-resistant Salmonella 4,[5],12:i:- in Guangdong, China.
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Fluoroquinolone resistance in Salmonella: insights by whole-genome sequencing.
Review
chromosomal mutations in gyrA contribute to fluoroquinolone resistance
Salmonella enterica Serovar Typhi in Bangladesh: Exploration of Genomic Diversity and Antimicrobial Resistance.
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Mutations in gyrA are associated with ciprofloxacin resistance.
Genomic Investigation of the Emergence of Invasive Multidrug-Resistant Salmonella enterica Serovar Dublin in Humans and Animals in Canada.
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Mutations in gyrA lead to fluoroquinolone resistance.
Global phylogenomics of multidrug-resistant Salmonella enterica serotype Kentucky ST198.
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Chromosomally and Plasmid-Located mcr in Salmonella from Animals and Food Products in China.
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Quinolone-resistant Escherichia coli at the interface between humans, poultry and their shared environment- a potential public health risk.
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Single substitution
Genomic Characterization and Genetic Profiles of Salmonella Gallinarum Strains Isolated from Layers with Fowl Typhoid in Colombia.
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Multidrug-resistant non-typhoidal Salmonella of public health significance recovered from migratory birds in Bangladesh.
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Whole-genome sequencing and phylogenetic analysis capture the emergence of a multi-drug resistant Salmonella enterica serovar Infantis clone from diagnostic animal samples in the United States.
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Mutation in gyr A gene conferring reduced susceptibility to ciprofloxacin
Genomic analysis and antimicrobial activity of β-lactam/β-lactamase inhibitors and other agents against KPC-producing Klebsiella pneumoniae clinical isolates from Brazilian hospitals.
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Phenotypic and genotypic antimicrobial resistance correlation and plasmid characterization in Salmonella spp. isolates from Italy reveal high heterogeneity among serovars.
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The Drug-Specific Propensity Regarding the Acquisition of Fluoroquinolone Resistance in Escherichia coli: An in vitro Challenge and DNA Mutation Analysis.
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Ongoing diversification of the global fish pathogen Piscirickettsia salmonis through genetic isolation and transposition bursts.
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Mutation leads to ciprofloxacin resistance
Molecular epidemiology and pathogenomics of extended-spectrum beta-lactamase producing- Escherichia coli and - Klebsiella pneumoniae isolates from bulk tank milk in Tennessee, USA.
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Mutations in gyrA contribute to fluoroquinolone resistance.
Antibiotic resistance of Helicobacter pylori in Nanjing, China: a cross-section study from 2018 to 2023.
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Multiple gyrA mutations were identified, including single, double, and one triple site mutation.
Antimicrobial resistance in invasive non-typhoid Salmonella from the Democratic Republic of the Congo: emergence of decreased fluoroquinolone susceptibility and extended-spectrum beta lactamases.
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mutations in codon 87 of the gyrA gene
Mechanisms of reduced susceptibility to ciprofloxacin in Escherichia coli isolates from Canadian hospitals.
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Mutations in the quinolone resistance-determining regions of gyrA and parC in Enterobacteriaceae isolates from Brazil.
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Multiple mutations in gyrA and parC genes are associated with high-level fluoroquinolone resistance.
Overview of the development of quinolone resistance in Salmonella species in China, 2005-2016.
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mutations in QRDRs of gyrA are associated with reduced CIP susceptibility
Phylogenetic Analysis Indicates a Longer Term Presence of the Globally Distributed H58 Haplotype of Salmonella Typhi in Southern India.
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Population structure and antimicrobial resistance patterns of Salmonella Typhi isolates in urban Dhaka, Bangladesh from 2004 to 2016.
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Prevalence of Salmonella Isolates and Their Distribution Based on Whole-Genome Sequence in a Chicken Slaughterhouse in Jiangsu, China.
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Mutation in the quinolone resistance-determining region (QRDR) of gyrA.
Molecular epidemiology of Salmonella Infantis in Europe: insights into the success of the bacterial host and its parasitic pESI-like megaplasmid.
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Epidemiological Study on Prevalence, Serovar Diversity, Multidrug Resistance, and CTX-M-Type Extended-Spectrum β-Lactamases of Salmonella spp. from Patients with Diarrhea, Food of Animal Origin, and Pets in Several Provinces of China.
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Genomic profiling of antimicrobial resistance genes in clinical isolates of Salmonella Typhi from patients infected with Typhoid fever in India.
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Antimicrobial Resistance in Salmonella enterica Serovar Paratyphi B Variant Java in Poultry from Europe and Latin America.
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The prevalence and mechanism of fluoroquinolone resistance in Escherichia coli isolated from swine farms in China.
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Mutations in the QRDR region
High relatedness of invasive multi-drug resistant non-typhoidal Salmonella genotypes among patients and asymptomatic carriers in endemic informal settlements in Kenya.
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Antimicrobial Resistance Profiles of Non-typhoidal Salmonella From Retail Meat Products in California, 2018.
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Mutation in the quinolone resistance-determining region (QRDR) of gyrA confers resistance to nalidixic acid and reduced susceptibility to ciprofloxacin.
Emergence of Resistant Escherichia coli Mutants in Microfluidic On-Chip Antibiotic Gradients.
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Mutations in gyrA, leading to fluoroquinolone resistance.
Genomic Analysis of Two MDR Isolates of Salmonella enterica Serovar Infantis from a Spanish Hospital Bearing the bla(CTX-M-65) Gene with or without fosA3 in pESI-like Plasmids.
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Spread of Carbapenem-Resistant Klebsiella pneumoniae Clinical Isolates Producing NDM-Type Metallo-β-Lactamase in Myanmar.
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A retrospective investigation of the population structure and geospatial distribution of Salmonella Paratyphi A in Kathmandu, Nepal.
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Mutations in gyrA were associated with reduced susceptibility to fluoroquinolones.
A multicenter genomic epidemiological investigation in Brazil, Chile, and Mexico reveals the diversity and persistence of Salmonella populations in surface waters.
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The origins of haplotype 58 (H58) Salmonella enterica serovar Typhi.
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Mutations in the quinolone resistance determining region (QRDR) of gyrA are associated with decreased fluoroquinolone susceptibility.
Investigation of gyrA and parC mutations and the prevalence of plasmid-mediated quinolone resistance genes in Klebsiella pneumoniae clinical isolates.
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Characterization of a Salmonella enterica serovar Typhimurium lineage with rough colony morphology and multidrug resistance.
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Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms.
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Mutations in gyrA are associated with resistance to fluoroquinolones.
Mutations in gyrA and parC genes in nalidixic acid-resistant Escherichia coli strains from food products, humans and animals.
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D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Detection of mutations in the gyrA and parC genes in Escherichia coli isolates carrying plasmid-mediated quinolone resistance genes from diseased food-producing animals.
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D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
4-Quinolone resistance mutations in the DNA gyrase of Escherichia coli clinical isolates identified by using the polymerase chain reaction.
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D87G or D87Y confer resistance to nalidixic acid only, if occurring alone. Unknown phenotype if D87H occurs alone
Comparative studies of mutations in animal isolates and experimental in vitro- and in vivo-selected mutants of Salmonella spp. suggest a counterselection of highly fluoroquinolone-resistant strains in the field.
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Salmonella typhimurium gyrA mutations associated with fluoroquinolone resistance.
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[Resistance to quinolones and beta-lactams in Salmonella enterica due to mutations in topoisomerase-encoding genes, altered cell permeability and expression of an active efflux system].
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Association between double mutation in gyrA gene of ciprofloxacin-resistant clinical isolates of Escherichia coli and MICs.
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Escherichia coli gyrA conferring resistance to fluoroquinolones; CARD accession: CARD:3003294
gyrA
Characterisation of novel mutations involved in quinolone resistance in Escherichia coli isolated from imported shrimp.
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Escherichia coli gyrA conferring resistance to fluoroquinolones; CARD accession: CARD:3003294
Prevalence of gyrA Mutations in Nalidixic Acid-Resistant Strains of Salmonella Enteritidis Isolated from Humans, Food, Chickens, and the Farm Environment in Brazil.
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Salmonella enterica gyrA conferring resistance to fluoroquinolones; CARD accession: CARD:3003926
High-level resistance to fluoroquinolones and cephalosporins in Burkholderia pseudomallei and closely related species.
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gyrA
Genetic evidence for a role of parC mutations in development of high-level fluoroquinolone resistance in Escherichia coli.
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gyrA
Contributions of individual mechanisms to fluoroquinolone resistance in 36 Escherichia coli strains isolated from humans and animals.
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gyrA
Molecular epidemiology and mutations at gyrA and parC genes of ciprofloxacin-resistant Escherichia coli isolates from a Taiwan medical center.
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gyrA
Mutation rate and evolution of fluoroquinolone resistance in Escherichia coli isolates from patients with urinary tract infections.
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gyrA
Mutations in GyrA, ParC, MexR and NfxB in clinical isolates of Pseudomonas aeruginosa.
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gyrA
Mechanisms of quinolone resistance in Escherichia coli and Salmonella: recent developments.
Review
gyrA
Antibiotic resistance among Escherichia coli and Salmonella isolated from dairy cattle feces in Texas.
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confers resistance to quinolones
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