Browse AMR Mutations
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
Overview
Rapid direct detection of multiple rifampin and isoniazid resistance mutations in Mycobacterium tuberculosis in respiratory samples by real-time PCR.
Research Article
Isoniazid-resistance conferring mutations in Mycobacterium tuberculosis KatG: catalase, peroxidase, and INH-NADH adduct formation activities.
Research Article
Mutations in KatG are associated with isoniazid resistance through reduced INH-NADH adduct formation.
Mycobacterium tuberculosis katG mutations conferring resistance to isoniazid; CARD accession: CARD:3003392
Computational modeling and bioinformatic analyses of functional mutations in drug target genes in Mycobacterium tuberculosis.
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Screening and characterization of mutations in isoniazid-resistant Mycobacterium tuberculosis isolates obtained in Brazil.
Research Article
Multiple mutations in katG codon 315 were identified, including S315T, S315N, and S315R.
Performance of the genotype MTBDR assay for molecular detection of multidrug-resistant strains of Mycobacterium tuberculosis.
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The S531L mutation was most common (21 of 35, 60%) in rpoB, and the S315T mutation was detected in 22 of 35 (63%) MDR-TB strains.
Selection of mutations to detect multidrug-resistant Mycobacterium tuberculosis strains in Shanghai, China.
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Improved rapid molecular diagnosis of multidrug-resistant tuberculosis using a new reverse hybridization assay, REBA MTB-MDR.
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Genotypic characterization of drug resistant Mycobacterium tuberculosis in Quebec, 2002-2012.
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most common mutation
Direct Detection of Rifampin and Isoniazid Resistance in Sputum Samples from Tuberculosis Patients by High-Resolution Melt Curve Analysis.
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Prevalence and Molecular Characteristics Based on Whole Genome Sequencing of Mycobacterium tuberculosis Resistant to Four Anti-Tuberculosis Drugs from Southern Xinjiang, China.
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Mutations in the katG gene are associated with isoniazid resistance.
Analysis on Drug-Resistance-Associated Mutations among Multidrug-Resistant Mycobacterium tuberculosis Isolates in China.
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A modified decision tree approach to improve the prediction and mutation discovery for drug resistance in Mycobacterium tuberculosis.
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Transmission of multidrug-resistant Mycobacterium tuberculosis in Wuhan, China: A retrospective molecular epidemiological study.
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Genetic diversity and transmission pattern of multidrug-resistant tuberculosis based on whole-genome sequencing in Wuhan, China.
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Comprehensive analysis of mutations associated with rifampicin- and isoniazid-resistant tuberculosis in a high-burden setting.
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associated with resistance
Use of real-time PCR and fluorimetry for rapid detection of rifampin and isoniazid resistance-associated mutations in Mycobacterium tuberculosis.
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Mutations Prevalent among Rifampin- and Isoniazid-Resistant Mycobacterium tuberculosis Isolates from a Hospital in Vietnam.
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Detection of multidrug resistance in Mycobacterium tuberculosis.
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mutations in katG are associated with isoniazid resistance
Molecular characteristics of rifampin- and isoniazid-resistant mycobacterium tuberculosis strains isolated in Vietnam.
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Comparative Analytical Evaluation of Four Centralized Platforms for the Detection of Mycobacterium tuberculosis Complex and Resistance to Rifampicin and Isoniazid.
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In-host population dynamics of Mycobacterium tuberculosis complex during active disease.
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Evolution and spread of a highly drug resistant strain of Mycobacterium tuberculosis in Papua New Guinea.
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associated with Isoniazid resistance
Fluoroquinolones and rifampin combination in the backdrop of heteroresistant tuberculosis.
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detected in inoculum and non-treated controls
Characterization of Drug Resistance Patterns, Mutation Profiles and Prevalence of Mycobacterium tuberculosis in Shaoxing.
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Whole genome sequencing based characterization of extensively drug-resistant Mycobacterium tuberculosis isolates from Pakistan.
Research Article
Mutations in the katG gene associated with isoniazid resistance
Integration of published information into a resistance-associated mutation database for Mycobacterium tuberculosis.
Review
Resistance to Isoniazid and Ethionamide in Mycobacterium tuberculosis: Genes, Mutations, and Causalities.
Review
Evaluation of GenoType MTBDRplus for the rapid detection of drug-resistant tuberculosis in Ghana.
Research Article
Mycobacterium tuberculosis whole genome sequencing and protein structure modelling provides insights into anti-tuberculosis drug resistance.
Research Article
Molecular characterisation of multidrug-resistant Mycobacterium tuberculosis isolates from a high-burden tuberculosis state in Brazil.
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Mutations in codon 315 were found in 106 isolates (80.9%).
Molecular characterization of multidrug-resistant Mycobacterium tuberculosis (MDR-TB) isolates identifies local transmission of infection in Kuwait, a country with a low incidence of TB and MDR-TB.
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Prevalence and genetic profiles of isoniazid resistance in tuberculosis patients: A multicountry analysis of cross-sectional data.
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Pyrosequencing for rapid detection of tuberculosis resistance in clinical isolates and sputum samples from re-treatment pulmonary tuberculosis patients.
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Sequence analysis for detection of drug resistance in Mycobacterium tuberculosis complex isolates from the Central Region of Cameroon.
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mutated in high level INH-resistant isolates
Application of next-generation sequencing to detect variants of drug-resistant Mycobacterium tuberculosis: genotype-phenotype correlation.
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Genomic analysis of the emergence of drug-resistant strains of Mycobacterium tuberculosis in the Middle East.
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Isoniazid Resistance in Mycobacterium tuberculosis Is a Heterogeneous Phenotype Composed of Overlapping MIC Distributions with Different Underlying Resistance Mechanisms.
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Mutations in katG contribute to isoniazid resistance.
Prevalence and molecular characterization of multidrug-resistant M. tuberculosis in Jiangxi province, China.
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In silico evaluation of WHO-endorsed molecular methods to detect drug resistant tuberculosis.
Research Article
Mutations at codon 315 of katG
Prevalence and genetic basis of first-line drug resistance of Mycobacterium tuberculosis in Ca Mau, Vietnam.
Research Article
Prevalence of Mycobacterium tuberculosis mutations associated with isoniazid and rifampicin resistance: A systematic review and meta-analysis.
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Using Microfluidic Chip and Allele-Specific PCR to Rapidly Identify Drug Resistance-Associated Mutations of Mycobacterium tuberculosis.
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Comparative Study on Tuberculosis Drug Resistance and Molecular Detection Methods Among Different Mycobacterium Tuberculosis Lineages.
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Antimicrobial drug resistant features of Mycobacterium tuberculosis associated with treatment failure.
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A precision overview of genomic resistance screening in Ecuadorian isolates of Mycobacterium tuberculosis using web-based bioinformatics tools.
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Correlation between the BACTEC MGIT 960 culture system with Genotype MTBDRplus and TB-SPRINT in multidrug resistant Mycobacterium tuberculosis clinical isolates from Brazil.
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Mutations of rpoB, katG, inhA and ahp genes in rifampicin and isoniazid-resistant Mycobacterium tuberculosis in Kyrgyz Republic.
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Validation of the FluoroType MTBDR Assay for Detection of Rifampin and Isoniazid Resistance in Mycobacterium tuberculosis Complex Isolates.
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Rational Design of Biosafety Level 2-Approved, Multidrug-Resistant Strains of Mycobacterium tuberculosis through Nutrient Auxotrophy.
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Mycobacterium tuberculosis Complex Lineage 3 as Causative Agent of Pulmonary Tuberculosis, Eastern Sudan
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The Hidden Epidemic of Isoniazid-Resistant Tuberculosis in South Africa.
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The catalogue of Mycobacterium tuberculosis mutations associated with drug resistance to 12 drugs in China from a nationwide survey: a genomic analysis.
Research Article
Integrating standardized whole genome sequence analysis with a global Mycobacterium tuberculosis antibiotic resistance knowledgebase.
Research Article
Mycobacterium tuberculosis katG mutations conferring resistance to isoniazid; CARD accession: CARD:3003392
A data compendium associating the genomes of 12,289 Mycobacterium tuberculosis isolates with quantitative resistance phenotypes to 13 antibiotics.
Research Article
Mycobacterium tuberculosis katG mutations conferring resistance to isoniazid; CARD accession: CARD:3003392
Mycobacterium tuberculosis katG mutations conferring resistance to isoniazid; CARD accession: CARD:3003392
Detection of novel mutations associated with independent resistance and cross-resistance to isoniazid and prothionamide in Mycobacterium tuberculosis clinical isolates.
Research Article
Mycobacterium tuberculosis katG mutations conferring resistance to prothionamide; CARD accession: CARD:3005102
Identification of a predominant genotype of Mycobacterium tuberculosis in Brazilian indigenous population.
Research Article
Mutations in katG are associated with isoniazid resistance.
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