ResLit - Antimicrobial Resistance Gene & Mutation Database

GenerpoB

Protein ChangeS455F

Nucleotide ChangeTCA->TTC

Validation StatusConfirmed2+ DBs

Databases

Card DatabaseReference Gene CatalogResFinder DatabaseReslit

Overview

Resistance To: rifampicin
Organisms: Acinetobacter baylyi, Escherichia coli
Papers: 2

Paper Information2

Horizontal Gene Transfer, Fitness Costs and Mobility Shape the Spread of Antibiotic Resistance Genes into Experimental Populations of Acinetobacter Baylyi.

Research Article

PMID 36788632 · 2023

Mutation Information

rpoB: p.S455F / c.TCA->TTC

Protein Change: S455F
Nucleotide Change: TCA->TTC
Organisms: Acinetobacter baylyi
Confers Resistance To: rifampicin
Validation Method: PCR amplification and transformation into A. baylyi ADP1 followed by selection on rifampicin-containing plates
Source Database: Reslit

Pervasive genotype-by-environment interactions shape the fitness effects of antibiotic resistance mutations.

Research Article

PMID 37583318 · 2023

All mutations are in the rpoB gene, which encodes the beta subunit of RNA polymerase.

Mutation Information

rpoB: p.S531F / c.TCA->TTC

Protein Change: S531F
Nucleotide Change: TCA->TTC
Organisms: Escherichia coli
Confers Resistance To: rifampicin
Validation Method: growth curves and MIC measurements
Source Database: Reslit

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