Browse AMR Mutations
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
Overview
Fluoromycobacteriophages for rapid, specific, and sensitive antibiotic susceptibility testing of Mycobacterium tuberculosis.
Prediction of antimicrobial resistance in clinical Campylobacter jejuni isolates from whole-genome sequencing data.
Identification of drug resistance mutations among Mycobacterium bovis lineages in the Americas.
Drug-Resistant Mycobacterium tuberculosis Isolates from New and Previously Treated TB Patients in China, 2017-2020.
DNA Breaks-Mediated Fitness Cost Reveals RNase HI as a New Target for Selectively Eliminating Antibiotic-Resistant Bacteria.
Str R mutation
High-throughput sequencing reveals genetic determinants associated with antibiotic resistance in Campylobacter spp. from farm-to-fork.
associated with aminoglycoside resistance
Practical approach to detection and surveillance of emerging highly resistant Mycobacterium tuberculosis Beijing 1071-32-cluster.
Mutation in rpsL
The whole-genome sequencing in predicting Mycobacterium tuberculosis drug susceptibility and resistance in Papua, Indonesia.
Whole-genome sequencing of Mycobacterium tuberculosis for prediction of drug resistance.
Mutations in rpsL were associated with streptomycin resistance.
Yersinia pestis antibiotic resistance: a systematic review.
Mutation in rpsl gene causes high-level streptomycin resistance
Snapshot of Mycobacterium tuberculosis Phylogenetics from an Indian State of Arunachal Pradesh Bordering China.
Molecular Epidemiology of Mycobacterium tuberculosis Complex Strains in Urban and Slum Settings of Nairobi, Kenya.
Transmission of multidrug-resistant tuberculosis in Jiangxi, China, and associated risk factors.
Potential of nanopore sequencing for tuberculosis diagnosis and drug resistance detection.
Clinical and Mycobacterium tuberculosis strain characteristics of tuberculosis patients with diabetes mellitus in Changping District, Beijing, China.
Outbreak Caused by Multidrug-Resistant Mycobacterium Tuberculosis with Unusual Combination of Resistance Mutations, Northern Argentina, 2006-2022.
associated with resistance
Nanopore-based targeted sequencing (NTS) for drug-resistant tuberculosis: an integrated tool for personalized treatment strategies and guidance for new drug development.
Key resistance-associated mutations in multidrug-resistant tuberculosis: a genomic study from Shanghai, China, with a focus on aminoglycosides.
Genetic antagonism and hypermutability in Mycobacterium smegmatis.
reverted to wild type at high frequency
Positive epistasis drives the acquisition of multidrug resistance.
Genomic diversity among drug sensitive and multidrug resistant isolates of Mycobacterium tuberculosis with identical DNA fingerprints.
Mutation leads to high level resistance.
Dynamic population changes in Mycobacterium tuberculosis during acquisition and fixation of drug resistance in patients.
Drug resistance-conferring mutations in Mycobacterium tuberculosis from Madang, Papua New Guinea.
Mycobacterium tuberculosis rpsL mutations conferring resistance to Streptomycin; CARD accession: CARD:3003395
Whole-genome sequencing of multidrug-resistant Mycobacterium tuberculosis isolates from Myanmar.
Draft genome sequence of Mycobacterium tuberculosis strain B9741 of Beijing B0/W lineage from HIV positive patient from Siberia.
Unveiling Antibiotic Resistance: Genome Sequencing of Streptomycin-Resistant Erwinia amylovora Isolate.
The mutation was identified in the EaSmR strain compared to the parental strain TS3128 and the reference genome CFBP1430.
A joint cross-border investigation of a cluster of multidrug-resistant tuberculosis in Austria, Romania and Germany in 2014 using classic, genotyping and whole genome sequencing methods: lessons learnt.
Genotypes and drug resistance pattern of Mycobacterium tuberculosis complex among clinically diagnosed pulmonary tuberculosis patients.
Prevalence and extent of heteroresistance by next generation sequencing of multidrug-resistant tuberculosis.
Genomic Analysis Reveals the Genetic Determinants Associated With Antibiotic Resistance in the Zoonotic Pathogen Campylobacter spp. Distributed Globally.
Mutations in rpsL are associated with streptomycin resistance.
Evolution of Antibiotic Resistance in Surrogates of Francisella tularensis (LVS and Francisella novicida): Effects on Biofilm Formation and Fitness.
Mutations in rpsL are associated with streptomycin resistance.
Clusters of Drug-Resistant Mycobacterium tuberculosis Detected by Whole-Genome Sequence Analysis of Nationwide Sample, Thailand, 2014-2017.
mutation in rpsL associated with streptomycin resistance
Whole-genome sequencing reveals transmission pattern and drug resistance of Mycobacterium tuberculosis intra- or inter-hosts.
Genomic Profiling of Mycobacterium tuberculosis Strains, Myanmar.
Prevalence and Molecular Characteristics Based on Whole Genome Sequencing of Mycobacterium tuberculosis Resistant to Four Anti-Tuberculosis Drugs from Southern Xinjiang, China.
Mutations in the rpsL gene are associated with streptomycin resistance.
Performance Evaluation of GeneLEAD/Deeplex Myc-TB for Mycobacterium tuberculosis Complex Diagnosis and Drug Susceptibility Testing
The Neglected Contribution of Streptomycin to the Tuberculosis Drug Resistance Problem.
Associated with high resistance levels.
Application of Amplicon-Based Targeted NGS Technology for Diagnosis of Drug-Resistant Tuberculosis Using FFPE Specimens.
high-confidence mutation
Proteomic Signatures of Antimicrobial Resistance in Yersinia pestis and Francisella tularensis.
Mutation in rpsL leads to streptomycin resistance in FSC016.
Mycobacterium tuberculosis Lineages Associated with Mutations and Drug Resistance in Isolates from India.
Whole genome sequencing analysis of Mycobacterium tuberculosis reveals circulating strain types and drug-resistance mutations in the Philippines.
Mutations associated with streptomycin resistance.
Genetic diversity and transmission pattern of multidrug-resistant tuberculosis based on whole-genome sequencing in Wuhan, China.
Clinical characteristics and genomic epidemiological survey of tuberculosis in Wuzhou, China, 2022.
Genomic characterization of multidrug-resistant tuberculosis in Shanghai, China: antibiotic resistance, virulence and transmission.
Whole-Genome Sequence-Based Diversity of Mycobacterium tuberculosis Strains Isolated from a Central Western Region of Mexico.
Evolution and spread of a highly drug resistant strain of Mycobacterium tuberculosis in Papua New Guinea.
associated with Streptomycin resistance
Detection of multidrug resistance in Mycobacterium tuberculosis.
mutations in rpsL are associated with streptomycin resistance
Prevalence and detailed mapping of the gonococcal genetic island in Neisseria meningitidis.
Mutation in rpsL confers streptomycin resistance.
A scalable metabolite supplementation strategy against antibiotic resistant pathogen Chromobacterium violaceum induced by NAD(+)/NADH(+) imbalance.
A missense mutation (K43R) in RpsL was identified in the streptomycin-resistant strain.
Dynamics of Extensive Drug Resistance Evolution of Mycobacterium tuberculosis in a Single Patient During 9 Years of Disease and Treatment.
Genome analyses of 174 strains of Mycobacterium tuberculosis provide insight into the evolution of drug resistance and reveal potential drug targets.
A novel mechanism of streptomycin resistance in Yersinia pestis: Mutation in the rpsL gene.
The mutation leads to high-level streptomycin resistance
Whole genome sequencing of clinical samples reveals extensively drug resistant tuberculosis (XDR TB) strains from the Beijing lineage in Nigeria, West Africa.
Antimicrobial Resistance in Campylobacter coli and Campylobacter jejuni from Human Campylobacteriosis in Taiwan, 2016 to 2019.
Mutations in rpsL confer resistance to streptomycin.
Whole genomic analysis uncovers high genetic diversity of rifampicin-resistant Mycobacterium tuberculosis strains in Botswana.
A comprehensive evaluation of a novel targeted-sequencing workflow for Mycobacterium species identification and anti-tuberculosis drug-resistance detection.
not covered by TB Pro assay
Transmission dynamics of drug-resistant tuberculosis in Ningbo, China: an epidemiological and genomic analysis.
Characterization of extensively drug-resistant Mycobacterium tuberculosis isolates circulating in Siberia.
associated with high-level streptomycin resistance
Molecular epidemiology of tuberculosis in Kaohsiung City located at southern Taiwan, 2000-2008.
Evaluation of gene mutations involved in drug resistance in mycobacterium tuberculosis strains derived from tuberculosis patients in mazandaran, iran, 2013.
Added value of whole-genome sequencing for management of highly drug-resistant TB.
Strong evidence for a causal association with a drug-resistant phenotype
GWAMAR: genome-wide assessment of mutations associated with drug resistance in bacteria.
Whole genome sequencing based characterization of extensively drug-resistant Mycobacterium tuberculosis isolates from Pakistan.
Mutations in the rpsL gene associated with streptomycin resistance
Clinical application of whole-genome sequencing to inform treatment for multidrug-resistant tuberculosis cases.
Transmitted Extended-Spectrum Extensively Drug-Resistant Tuberculosis in Beijing, China, with Discordant Whole-Genome Sequencing Analysis Results.
Mycobacterium tuberculosis whole genome sequencing and protein structure modelling provides insights into anti-tuberculosis drug resistance.
Prevalence and molecular characteristics of drug-resistant Mycobacterium tuberculosis in Beijing, China: 2006 versus 2012.
Mycobacterium tuberculosis whole genome sequencing provides insights into the Manila strain and drug-resistance mutations in the Philippines.
Confirmed in the study
Genetic Diversity and Molecular Epidemiology of Mycobacterium tuberculosis in Roraima State, Brazil.
Prevalence, risk and genetic characteristics of drug-resistant tuberculosis in a tertiary care tuberculosis hospital in China.
Molecular characterization of multidrug-resistant Mycobacterium tuberculosis (MDR-TB) isolates identifies local transmission of infection in Kuwait, a country with a low incidence of TB and MDR-TB.
A retrospective genomic analysis of drug-resistant strains of M. tuberculosis in a high-burden setting, with an emphasis on comparative diagnostics and reactivation and reinfection status.
Genomic Analysis of Mycobacterium tuberculosis Isolates and Construction of a Beijing Lineage Reference Genome.
The K43R mutation in rpsL was found in TCDC11, TCDC5, TCDC4, and TCDC10.
Evaluation of Mutations Related to Streptomycin Resistance in Mycobacterium tuberculosis Clinical Isolates.
Rapid detection of multidrug resistance in tuberculosis using nanopore-based targeted next-generation sequencing: a multicenter, double-blind study.
Common mutation in rpsL
Identification of knowledge gaps in whole-genome sequence analysis of multi-resistant thermotolerant Campylobacter spp.
Development of a multiplex droplet digital PCR method for detection and monitoring of Mycobacterium tuberculosis and drug-resistant tuberculosis.
Drug Susceptibility and Mutation Profiles in Mycobacterium tuberculosis Isolates from a Tertiary Care Hospital in Kerala, India.
Evaluation of the AID TB resistance line probe assay for rapid detection of genetic alterations associated with drug resistance in Mycobacterium tuberculosis strains.
Pyrosequencing for rapid detection of tuberculosis resistance in clinical isolates and sputum samples from re-treatment pulmonary tuberculosis patients.
Prevalence and molecular characteristics of drug-resistant Mycobacterium tuberculosis in Hunan, China.
Sequence analysis for detection of drug resistance in Mycobacterium tuberculosis complex isolates from the Central Region of Cameroon.
mutated in SM-resistant isolates
Optimizing multiplex SNP-based data analysis for genotyping of Mycobacterium tuberculosis isolates.
Screening for streptomycin resistance-conferring mutations in Mycobacterium tuberculosis clinical isolates from Poland.
A complete high-quality MinION nanopore assembly of an extensively drug-resistant Mycobacterium tuberculosis Beijing lineage strain identifies novel variation in repetitive PE/PPE gene regions.
Detection of a streptomycin-resistant Mycobacterium bovis strain through antitubercular drug susceptibility testing of Tunisian Mycobacterium tuberculosis complex isolates from cattle.
Compensatory evolution drives multidrug-resistant tuberculosis in Central Asia.
Molecular drug susceptibility testing and strain typing of tuberculosis by DNA hybridization.
Longitudinal Outbreak of Multidrug-Resistant Tuberculosis in a Hospital Setting, Serbia.
Genomic analysis of the emergence of drug-resistant strains of Mycobacterium tuberculosis in the Middle East.
Genome-resolved insight into the reservoir of antibiotic resistance genes in aquatic microbial community.
Comparative genomics of drug-resistant strains of Mycobacterium tuberculosis in Ecuador.
FLASH-TB: an Application of Next-Generation CRISPR to Detect Drug Resistant Tuberculosis from Direct Sputum.
Clinical, Bacteriological, and Genetic Characterization of Bone and Joint Infections Involving Linezolid-Resistant Staphylococcus epidermidis: a Retrospective Multicenter Study in French Reference Centers.
Evolution and epidemic success of Mycobacterium tuberculosis in eastern China: evidence from a prospective study.
Mutations in rpsL are associated with streptomycin resistance.
Using Microfluidic Chip and Allele-Specific PCR to Rapidly Identify Drug Resistance-Associated Mutations of Mycobacterium tuberculosis.
Molecular Analysis of Anti-Tuberculosis Drug Resistance of Mycobacterium tuberculosis Isolated in the Republic of Korea.
Comparative Study on Tuberculosis Drug Resistance and Molecular Detection Methods Among Different Mycobacterium Tuberculosis Lineages.
Analysis of Drug-Resistance Characteristics and Genetic Diversity of Multidrug-Resistant Tuberculosis Based on Whole-Genome Sequencing on the Hainan Island, China.
Three genes controlling streptomycin susceptibility in Agrobacterium fabrum.
Genotypic and phenotypic comparison of drug resistance profiles of clinical multidrug-resistant Mycobacterium tuberculosis isolates using whole genome sequencing in Latvia.
The MAGMA pipeline for comprehensive genomic analyses of clinical Mycobacterium tuberculosis samples.
A preliminary evaluation of targeted nanopore sequencing technology for the detection of Mycobacterium tuberculosis in bronchoalveolar lavage fluid specimens.
Monitoring of First-line Drug Resistance Mutations Outside the Scope of Xpert MTB/RIF Ultra is Needed for Successful Control of DR-TB in Southern Mozambique.
A precision overview of genomic resistance screening in Ecuadorian isolates of Mycobacterium tuberculosis using web-based bioinformatics tools.
Machine learning and phylogenetic analysis allow for predicting antibiotic resistance in M. tuberculosis.
associated with resistance to aminoglycosides
High-resolution melting analysis for the rapid detection of fluoroquinolone and streptomycin resistance in Mycobacterium tuberculosis.
Mutations in rpsL were associated with streptomycin resistance.
Analysis of mutations in streptomycin-resistant strains reveals a simple and reliable genetic marker for identification of the Mycobacterium tuberculosis Beijing genotype.
Mutations in the rpsL gene are associated with streptomycin resistance.
Characterization of multi-drug resistant Mycobacterium tuberculosis from immigrants residing in the USA using Ion Torrent full-gene sequencing.
Cases 1 and 2
A streptomycin resistance marker in H. parasuis based on site-directed mutations in rpsL gene to perform unmarked in-frame mutations and to verify natural transformation.
Multi-clonal evolution of multi-drug-resistant/extensively drug-resistant Mycobacterium tuberculosis in a high-prevalence setting of Papua New Guinea for over three decades.
Whole-Genome Analysis of Mycobacterium tuberculosis from Patients with Tuberculous Spondylitis, Russia.
Signatures of Selection at Drug Resistance Loci in Mycobacterium tuberculosis.
dominant STR resistance mutation
Multi- and Extensively Drug Resistant Mycobacterium tuberculosis in South Africa: a Molecular Analysis of Historical Isolates.
Genotypic drug resistance using whole-genome sequencing of Mycobacterium tuberculosis clinical isolates from North-western Tanzania.
Interaction between rpsL and gyrA mutations affects the fitness and dual resistance of Mycobacterium tuberculosis clinical isolates against streptomycin and fluoroquinolones.
Molecular Targets Related Drug Resistance Mechanisms in MDR-, XDR-, and TDR-Mycobacterium tuberculosis Strains.
K43R mutation is the most common mutation associated with STR resistance.
Accuracy of whole genome sequencing versus phenotypic (MGIT) and commercial molecular tests for detection of drug-resistant Mycobacterium tuberculosis isolated from patients in Brazil and Mozambique.
Most frequent mutation associated with streptomycin resistance in Mozambican isolates
Direct Whole-Genome Sequencing of Sputum Accurately Identifies Drug-Resistant Mycobacterium tuberculosis Faster than MGIT Culture Sequencing.
Whole genome sequencing of Mycobacterium tuberculosis isolates and clinical outcomes of patients treated for multidrug-resistant tuberculosis in Tanzania.
Mutation in rpsL gene associated with streptomycin resistance.
Phylogenomic assessment of drug-resistant Mycobacterium tuberculosis strains from Beira, Mozambique.
Mycobacterium tuberculosis Complex Lineage 3 as Causative Agent of Pulmonary Tuberculosis, Eastern Sudan
Antibiotic Susceptibility Profiles of Lactic Acid Bacteria from the Human Vagina and Genetic Basis of Acquired Resistances.
associated with streptomycin resistance
Detection of drug resistant Mycobacterium tuberculosis by high-throughput sequencing of DNA isolated from acid fast bacilli smears.
Mutations in rpsL are associated with streptomycin resistance.
Whole Genome and Transcriptome Sequencing of Two Multi-Drug Resistant Mycobacterium tuberculosis Strains to Facilitate Illustrating Their Virulence in vivo.
Emergence of multidrug-resistant Mycobacterium tuberculosis of the Beijing lineage in Portugal and Guinea-Bissau: a snapshot of moving clones by whole-genome sequencing.
Present in GC1 isolates.
Exploiting Homoplasy in Genome-Wide Association Studies to Enhance Identification of Antibiotic-Resistance Mutations in Bacterial Genomes.
Breaking the Rebellion: Photodynamic Inactivation against Erwinia amylovora Resistant to Streptomycin.
The rpsL mutation was identified as a mechanism of streptomycin resistance in E. amylovora SmR.
Drug resistant Mycobacterium tuberculosis in Oman: resistance-conferring mutations and lineage diversity.
Transmission of dominant strains of Campylobacter jejuni and Campylobacter coli between farms and retail stores in Ecuador: Genetic diversity and antimicrobial resistance.
Unpredictability of the Fitness Effects of Antimicrobial Resistance Mutations Across Environments in Escherichia coli.
rpsL
Integrating standardized whole genome sequence analysis with a global Mycobacterium tuberculosis antibiotic resistance knowledgebase.
Mycobacterium tuberculosis rpsL mutations conferring resistance to Streptomycin; CARD accession: CARD:3003395
A data compendium associating the genomes of 12,289 Mycobacterium tuberculosis isolates with quantitative resistance phenotypes to 13 antibiotics.
Mycobacterium tuberculosis rpsL mutations conferring resistance to Streptomycin; CARD accession: CARD:3003395
Mycobacterium tuberculosis rpsL mutations conferring resistance to Streptomycin; CARD accession: CARD:3003395
Mutations in the rpsL gene are involved in streptomycin resistance in Campylobacter coli.
Tuberculosis drug resistance mutation database.
Characterization of mutations in multi- and extensive drug resistance among strains of Mycobacterium tuberculosis clinical isolates in Republic of Korea.
Detection of streptomycin and quinolone resistance in Mycobacterium tuberculosis by a low-density DNA array.
Activation of the dormant secondary metabolite production by introducing gentamicin-resistance in a marine-derived Penicillium purpurogenum G59.
The rpsL mutation was responsible for the gentamicin resistance in the mutant 5-1-4.
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