Browse AMR Mutations
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
Overview
Sequence analysis of the gyrA and parC homologues of a wild-type strain of Vibrio parahaemolyticus and its fluoroquinolone-resistant mutants.
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gyrA
Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes clinical isolates with alterations in GyrA and ParC proteins.
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mutations in gyrA are associated with fluoroquinolone resistance
Role of active efflux in association with target gene mutations in fluoroquinolone resistance in clinical isolates of Vibrio cholerae.
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Mutations in gyrA are associated with fluoroquinolone resistance
gyrA
An unusually high level of quinolone resistance associated with type II topoisomerase mutations in quinolone resistance-determining regions of Aeromonas caviae isolated from diarrhoeal patients.
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Spontaneous quinolone resistance in the zoonotic serovar of Vibrio vulnificus.
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Mutation in gyrA leads to quinolone resistance
gyrA
Vibrio cholerae O1 variant with reduced susceptibility to ciprofloxacin, Western Africa.
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First description of the qnrS-like (qnrS5) gene and analysis of quinolone resistance-determining regions in motile Aeromonas spp. from diseased fish and water.
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Mutations in QRDR of gyrA contribute to quinolone resistance.
Predicting antimicrobial susceptibilities for Escherichia coli and Klebsiella pneumoniae isolates using whole genomic sequence data.
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associated with ciprofloxacin resistance
Novel multiple mutations in the topoisomerase gene of Haitian variant Vibrio cholerae O1.
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Single mutation in the gyrA gene contributes to ciprofloxacin resistance.
Thiophene antibacterials that allosterically stabilize DNA-cleavage complexes with DNA gyrase.
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Mutations in gyrA confer resistance to fluoroquinolones
In vivo selection of a multidrug-resistant Aeromonas salmonicida during medicinal leech therapy.
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DNA Gyrase and Topoisomerase IV Mutations and their effect on Quinolones Resistant Proteus mirabilis among UTIs Patients.
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The Impact of Selected Bacterial Sexually Transmitted Diseases on Pregnancy and Female Fertility.
Review
Distribution of fluoroquinolone resistance determinants in Carbapenem-resistant Klebsiella pneumoniae clinical isolates associated with bloodstream infections in China.
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Antimicrobial Resistance in Chlamydia trachomatis: Mechanisms and Mutations
Review
Mutations in gyrA are associated with fluoroquinolone resistance in C. trachomatis.
Mutational Diversity in the Quinolone Resistance-Determining Regions of Type-II Topoisomerases of Salmonella Serovars.
Review
Common mutation in S. Typhi and other Salmonella serovars.
The Evolutionary Trend and Genomic Features of an Emerging Lineage of Elizabethkingia anophelis Strains in Taiwan.
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associated with ciprofloxacin resistance
Antimicrobial Resistance and Virulence Characteristics of Klebsiella pneumoniae Isolates in Kenya by Whole-Genome Sequencing.
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Comprehensive genomic insights into a highly pathogenic clone ST656 of mcr8.1 containing multidrug-resistant Klebsiella pneumoniae from Bangladesh.
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Quinolone resistance in Riemerella anatipestifer from Thai ducks: Mutation analysis of gyrA, parC, and plasmid-mediated quinolone resistance genes.
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35 isolates
Genomic diversity and antimicrobial resistance of Vibrio cholerae isolates from Africa: a PulseNet Africa initiative using nanopore sequencing to enhance genomic surveillance.
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Specific patterns of gyrA mutations determine the resistance difference to ciprofloxacin and levofloxacin in Klebsiella pneumoniae and Escherichia coli.
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Mutations in gyrA are responsible for fluoroquinolone resistance.
Characterization of Multi-Drug Resistant Enterococcus faecalis Isolated from Cephalic Recording Chambers in Research Macaques (Macaca spp.).
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Single amino acid polymorphism in gyrA codon 83 (Ser to Ile)
Characterization and Genetic Variation of Vibrio cholerae Isolated from Clinical and Environmental Sources in Thailand.
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Vibrio cholerae O1 with Reduced Susceptibility to Ciprofloxacin and Azithromycin Isolated from a Rural Coastal Area of Bangladesh.
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Mutation in gyrA is associated with reduced susceptibility to ciprofloxacin.
Genomic features, phylogenetic relationships, and comparative genomics of Elizabethkingia anophelis strain EM361-97 isolated in Taiwan.
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Genomic evolution of the globally disseminated multidrug-resistant Klebsiella pneumoniae clonal group 147.
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Mutation in gyrA leads to decreased susceptibility to fluoroquinolones.
NDM-1 Introduction in Portugal through a ST11 KL105 Klebsiella pneumoniae Widespread in Europe.
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Healthcare-associated infections caused by chlorhexidine-tolerant Serratia marcescens carrying a promiscuous IncHI2 multi-drug resistance plasmid in a veterinary hospital.
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Mutation in GyrA conferring fluoroquinolone resistance
The GyrA mutation reported here is relatively rare in these genomes
WQ-3810, a fluoroquinolone with difluoropyridine derivative as the R1 group exerts high potency against quinolone-resistant Campylobacter jejuni.
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Molecular Epidemiology and Clinical Characterization of Carbapenemase-Producing Enterobacter Species From an International Cohort.
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Whole Genome Sequencing of Drug-Resistant Vibrio cholerae Serotype Ogawa from an Outbreak in Khyber Pakhtunkhwa.
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Type II topoisomerase quinolone resistance-determining regions of Aeromonas caviae, A. hydrophila, and A. sobria complexes and mutations associated with quinolone resistance.
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Mutation at position 83 in gyrA leads to quinolone resistance.
Mechanism of drug resistance in clonally related clinical isolates of Vibrio fluvialis isolated in Kolkata, India.
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Mutation in the quinolone resistance-determining region of gyrA
Drug-resistance mechanisms in Vibrio cholerae O1 outbreak strain, Haiti, 2010.
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Taxonomic Identification of Different Species of the Genus Aeromonas by Whole-Genome Sequencing and Use of Their Species-Specific β-Lactamases as Phylogenetic Markers.
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Molecular characterization of fluoroquinolone-resistant Escherichia coli from broiler breeder farms.
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Mutations in gyrA are associated with high-level fluoroquinolone resistance.
Phylogenetic and antimicrobial drug resistance analysis of Vibrio cholerae O1 isolates from Ghana.
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Mutations in the gyrA and parC genes were identified using CholeraeFinder with manual identification of mutations sites.
Transcriptional Response of Multidrug-Resistant Klebsiella pneumoniae Clinical Isolates to Ciprofloxacin Stress.
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Extensive Drug-Resistant Salmonella enterica Isolated From Poultry and Humans: Prevalence and Molecular Determinants Behind the Co-resistance to Ciprofloxacin and Tigecycline.
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Mutations in gyrA gene were detected at codon S83 or D87 or both in 89.66% of XDR Salmonella.
Global population structure of the Serratia marcescens complex and identification of hospital-adapted lineages in the complex.
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Outbreak of Imported Seventh Pandemic Vibrio cholerae O1 El Tor, Algeria, 2018.
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Molecular Epidemiology and In-Depth Characterization of Klebsiella pneumoniae Clinical Isolates from Armenia.
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Genomic characterization of multidrug-resistant extended-spectrum β-lactamase-producing Vibrio cholerae O1 strains from 2022 cholera outbreak in Kenya.
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Combating Klebsiella pneumoniae: from antimicrobial resistance mechanisms to phage-based combination therapies.
Review
Mutations in gyrA contribute to quinolone resistance.
Emergence and regional spread of extended-spectrum β-lactamase-producing Klebsiella pneumoniae ST307 at a Japanese tertiary-care hospital.
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A first look into the genomic characterization and fluoroquinolone resistance genotypes of Mycoplasma spp. in Colombian poultry.
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Mutations detected in MG field strains.
Comparative analysis of quinolone resistance in clinical isolates of Klebsiella pneumoniae and Escherichia coli from Chinese children and adults.
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Identification and characterisation of a novel plasmid-mediated quinolone resistance gene, qnrVC7, in Vibrio cholerae of seafood origin.
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Hybrid Vibrio cholerae El Tor lacking SXT identified as the cause of a cholera outbreak in the Philippines.
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Point mutation in the gyrase gene (gyrA)
Deoxynybomycins inhibit mutant DNA gyrase and rescue mice infected with fluoroquinolone-resistant bacteria.
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Mutations in GyrA are responsible for fluoroquinolone resistance and are targeted by deoxynybomycin.
Characterization and Genomic Analysis of Quinolone-Resistant Delftia sp. 670 Isolated from a Patient Who Died from Severe Pneumonia.
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Increasing prevalence of ciprofloxacin-resistant food-borne Salmonella strains harboring multiple PMQR elements but not target gene mutations.
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Single or double mutations in gyrA and/or parC
Stepwise evolution of pandrug-resistance in Klebsiella pneumoniae.
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The Lake Chad Basin, an Isolated and Persistent Reservoir of Vibrio cholerae O1: A Genomic Insight into the Outbreak in Cameroon, 2010.
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Interplay Between the Phenotype and Genotype, and Efflux Pumps in Drug-Resistant Strains of Riemerella anatipestifer.
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Mutations in gyrA were associated with fluoroquinolone resistance.
Molecular Epidemiology of Multidrug-Resistant Klebsiella pneumoniae Isolates in a Brazilian Tertiary Hospital.
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An Outbreak of Carbapenem-Resistant and Hypervirulent Klebsiella pneumoniae in an Intensive Care Unit of a Major Teaching Hospital in Wenzhou, China.
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Impact of co-existence of PMQR genes and QRDR mutations on fluoroquinolones resistance in Enterobacteriaceae strains isolated from community and hospital acquired UTIs.
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Whole-genome sequence and resistance determinants of four Elizabethkingia anophelis clinical isolates collected in Hanoi, Vietnam.
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Mutations in QRDR region of gyrA gene.
Sequencing of gyrase and topoisomerase IV quinolone-resistance-determining regions of Chlamydia trachomatis and characterization of quinolone-resistant mutants obtained In vitro.
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The mutation was found in both resistant strains L2-OFXR and L2-SPXR.
Vibrio fluvialis: an emerging human pathogen.
Review
Molecular analysis of ciprofloxacin resistance mechanisms in Malaysian ESBL-producing Klebsiella pneumoniae isolates and development of mismatch amplification mutation assays (MAMA) for rapid detection of gyrA and parC mutations.
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Resistance determinants and mobile genetic elements of an NDM-1-encoding Klebsiella pneumoniae strain.
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Cholera outbreaks (2012) in three districts of Nepal reveal clonal transmission of multi-drug resistant Vibrio cholerae O1.
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The draft genomes of Elizabethkingia anophelis of equine origin are genetically similar to three isolates from human clinical specimens.
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The wild-type gyrA gene was not experimentally validated as conferring resistance, but the mutation Ser83Ile was found to be associated with increased ciprofloxacin MIC.
Molecular typing and profiling of topoisomerase mutations causing resistance to ciprofloxacin and levofloxacin in Elizabethkingia species.
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Characterizing Mobilized Virulence Factors and Multidrug Resistance Genes in Carbapenemase-Producing Klebsiella pneumoniae in a Sri Lankan Hospital.
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Spread of GES-5 carbapenemase-producing Pseudomonas aeruginosa clinical isolates in Japan due to clonal expansion of ST235.
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Comparison of Clinical Manifestations, Antimicrobial Susceptibility Patterns, and Mutations of Fluoroquinolone Target Genes between Elizabethkingia meningoseptica and Elizabethkingia anophelis Isolated in Taiwan.
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Antimicrobial resistance of Vibrio cholerae from sub-Saharan Africa: A systematic review.
Review
Prevalence and mechanism of fluoroquinolone resistance in clinical isolates of Proteus mirabilis in Japan.
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Human pandemic K27-ST392 CTX-M-15 extended-spectrum β-lactamase-positive Klebsiella pneumoniae: A one health clone threatening companion animals.
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Omadacycline Is Highly Active In Vitro against Mycoplasma genitalium.
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Genomic Analysis of Klebsiella pneumoniae ST258 Strain Coproducing KPC-2 and CTX-M-14 Isolated from Poultry in the Brazilian Amazon Region.
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Carbapenem-Resistant and ESBL-Producing Enterobacterales Emerging in Central Texas.
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Mutations in gyrA contribute to fluoroquinolone resistance.
Whole-genome sequencing of Histophilus somni strains isolated in Russia.
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The Ser83Ile substitution was identified in the DNA topoisomerase II (gyrA) in H. somni strains 532-VIEV and 551-VIEV.
Situational analysis on fluoroquinolones use and characterization of high-level ciprofloxacin-resistant Enterococcus faecalis by integrated broiler operations in South Korea.
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A Nationwide Genomic Study of Clinical Klebsiella pneumoniae Carrying bla(OXA-232) and rmtF in China.
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Antibiotic-Resistant Vibrio cholerae O1 and Its SXT Elements Associated with Two Cholera Epidemics in Kenya in 2007 to 2010 and 2015 to 2016.
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Phenotypic and Genotypic Antimicrobial Susceptibility Testing of Chlamydia trachomatis Isolates from Patients with Persistent or Clinical Treatment Failure in Spain.
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No mutations were found in the gyrA gene.
Dissemination of the high-risk cloneST147 carbapenem-resistant klebsiella pneumoniae from a local tertiary care hospital in the Republic of Korea.
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Genomic analysis and antimicrobial activity of β-lactam/β-lactamase inhibitors and other agents against KPC-producing Klebsiella pneumoniae clinical isolates from Brazilian hospitals.
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Phylogenetic lineages and antimicrobial resistance determinants of clinical Klebsiella oxytoca spanning local to global scales.
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Unveiling the genome of a high-risk pandrug-resistant Klebsiella pneumoniae emerging in the Brazilian Amazon Region, 2022.
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Emergence and persistent spread of carbapenemase-producing Klebsiella pneumoniae high-risk clones in Greek hospitals, 2013 to 2022.
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Genome-based assessment of antimicrobial resistance reveals the lineage specificity of resistance and resistance gene profiles in Riemerella anatipestifer from China.
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Ciprofloxacin-resistant Aeromonas hydrophila cellulitis following leech therapy.
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gyrA mutation responsible for ciprofloxacin resistance
Clinical isolates of Vibrio cholerae O1 El Tor Ogawa of 2009 from Kolkata, India: preponderance of SXT element and presence of Haitian ctxB variant.
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Cholera outbreaks in Nigeria are associated with multidrug resistant atypical El Tor and non-O1/non-O139 Vibrio cholerae.
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Copy Number Change of the NDM-1 sequence in a multidrug-resistant Klebsiella pneumoniae clinical isolate.
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Multi-Drug Resistance Mediated by Class 1 Integrons in Aeromonas Isolated from Farmed Freshwater Animals.
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The Genomic Basis of Intrinsic and Acquired Antibiotic Resistance in the Genus Serratia.
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Resistome of carbapenem- and colistin-resistant Klebsiella pneumoniae clinical isolates.
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mutations in gyrA
Molecular Characteristics and Antimicrobial Susceptibility Profiles of Elizabethkingia Clinical Isolates in Shanghai, China.
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Genomic characterization of the non-O1/non-O139 Vibrio cholerae strain that caused a gastroenteritis outbreak in Santiago, Chile, 2018.
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Mutations S83I and A171S in GyrA confer resistance to nalidixic acid.
Spread of Carbapenem-Resistant Klebsiella pneumoniae Clinical Isolates Producing NDM-Type Metallo-β-Lactamase in Myanmar.
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The First Saudi Report of Novel and Common Mutations in the gyrA and parC Genes Among Pseudomonas Spp. Clinical Isolates Recovered from Taif Area.
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Common mutation in gyrA
Mycoplasma genitalium macrolide and fluoroquinolone resistance in pregnant women in Papua New Guinea.
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No macrolide resistance mutations were found.
Whole-genome sequencing-based prediction and analysis of antimicrobial resistance in Yersinia enterocolitica from Ningxia, China.
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Mutations in gyrA are associated with fluoroquinolone resistance.
Emergence of Carbapenem-resistant Clinical Isolates of Providencia Species.
Review
Investigation of gyrA and parC mutations and the prevalence of plasmid-mediated quinolone resistance genes in Klebsiella pneumoniae clinical isolates.
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Comparative in vitro activity of Delafloxacin and other antimicrobials against isolates from patients with acute bacterial skin, skin-structure infection and osteomyelitis.
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Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.
Review
Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone
Alterations in the GyrA subunit of DNA gyrase and the ParC subunit of DNA topoisomerase IV associated with quinolone resistance in Enterococcus faecalis.
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Phenotype described only in association with parC mutations, unknown phenotype if the present mutation occurs alone
Salmonella typhimurium gyrA mutations associated with fluoroquinolone resistance.
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Comparative studies of mutations in animal isolates and experimental in vitro- and in vivo-selected mutants of Salmonella spp. suggest a counterselection of highly fluoroquinolone-resistant strains in the field.
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Characterisation of novel mutations involved in quinolone resistance in Escherichia coli isolated from imported shrimp.
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Escherichia coli gyrA conferring resistance to fluoroquinolones; CARD accession: CARD:3003294
gyrA mutations associated with fluoroquinolone resistance in eight species of Enterobacteriaceae.
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gyrA
Amino Acid Substitution Ser83Ile in GyrA of DNA Gyrases Confers High-Level Quinolone Resistance to Nontyphoidal Salmonella Without Loss of Supercoiling Activity.
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gyrA
A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A.
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Mutations in gyrA are associated with decreased fluoroquinolone susceptibility.
Genetic Diversity, Distribution, and Genomic Characterization of Antibiotic Resistance and Virulence of Clinical Pseudomonas aeruginosa Strains in Kenya.
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Mutations in gyrA contribute to fluoroquinolone resistance.
Efficacy and potential for resistance selection of antipseudomonal treatments in a mouse model of lung infection by hypermutable Pseudomonas aeruginosa.
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GyrA Thr-83-Ile mutation was observed in in vitro and in vivo ciprofloxacin-resistant mutants.
Vibrio cholerae O47 associated with a cholera-like diarrheal outbreak concurrent with seasonal cholera in Bangladesh.
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Emergence of antibiotic resistance from multinucleated bacterial filaments.
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Determining antimicrobial susceptibility in Salmonella enterica serovar Typhimurium through whole genome sequencing: a comparison against multiple phenotypic susceptibility testing methods.
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Commonality of Multidrug-Resistant Klebsiella pneumoniae ST348 Isolates in Horses and Humans in Portugal.
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Present in isolates C1685 and Kp56
Detection of Chromosomal and Plasmid-Mediated Quinolone Resistance Among Escherichia coli Isolated from Urinary Tract Infection Cases; Zagazig University Hospitals, Egypt.
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Mutations at Ser-83 and Asp-87 in the gyrA gene were detected in 76.7% of isolates.
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