Browse AMR Mutations
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
Overview
Molecular characterization of multidrug-resistant isolates of Mycobacterium tuberculosis from patients in North India.
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Emergence and molecular characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates from the Delhi Region in India.
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Previously reported
Molecular drug susceptibility testing against the first-line (rifampin and isoniazid) and second-line (ciprofloxacin-amikacin and kanamycin) treatment in different subtypes of Mycobacterium simiae.
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Comprehensive Determination of Mycobacterium tuberculosis and Nontuberculous Mycobacteria From Targeted Capture Sequencing.
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Computational modeling and bioinformatic analyses of functional mutations in drug target genes in Mycobacterium tuberculosis.
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Emergence of multi-drug-resistant Mycobacterium tuberculosis in Niger: A snapshot based on whole-genome sequencing.
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Detected in M. tuberculosis Z229 (other, sub-lineage 4.6.2.2 Cameroon).
Drug resistant Mycobacterium tuberculosis strains have altered cell envelope hydrophobicity that influences infection outcomes in human macrophages.
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Mutations in gyrA are associated with fluoroquinolone resistance in pre-XDR strains.
Evaluation of a new line probe assay for rapid identification of gyrA mutations in Mycobacterium tuberculosis.
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associated with fluoroquinolone resistance
Genome sequence comparisons of serial multi-drug-resistant Mycobacterium tuberculosis isolates over 21 years of infection in a single patient.
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Whole genome analysis of extensively drug resistant Mycobacterium tuberculosis strains in Peru.
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Performance Evaluation of GeneLEAD/Deeplex Myc-TB for Mycobacterium tuberculosis Complex Diagnosis and Drug Susceptibility Testing
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Molecular Epidemiology and Polymorphism Analysis in Drug-Resistant Genes in M. tuberculosis Clinical Isolates from Western and Northern India.
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variable codons
Genetic diversities and drug resistance in Mycobacterium bovis isolates from zoonotic tuberculosis using whole genome sequencing.
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Detection of multidrug resistance in Mycobacterium tuberculosis.
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mutations in gyrA are associated with fluoroquinolone resistance
Effect of efflux pump inhibitors on drug susceptibility of ofloxacin resistant Mycobacterium tuberculosis isolates.
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Seven isolates showed mutations at codon Asp94Tyr, Asp94Val, Asp94Gly, Gly88Arg, Arg98Leu, and Ser95Thr.
Evaluation of the Xpert MTB/XDR test for detection of isoniazid, fluoroquinolones, and second-line injectable drugs resistance to Mycobacterium tuberculosis-Anhui Province, China.
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Characterization of extensively drug-resistant Mycobacterium tuberculosis isolates circulating in Siberia.
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associated with ofloxacin resistance
Clinical application of whole-genome sequencing to inform treatment for multidrug-resistant tuberculosis cases.
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Mutations conferring resistance to first- and second-line drugs in multidrug-resistant Mycobacterium tuberculosis clinical isolates in southeast Mexico.
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Draft Genome Sequence of Mycobacterium tuberculosis Strain E186hv of Beijing B0/W Lineage with Reduced Virulence.
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associated with ofloxacin resistance
Transmitted Extended-Spectrum Extensively Drug-Resistant Tuberculosis in Beijing, China, with Discordant Whole-Genome Sequencing Analysis Results.
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Genome Analysis of the First Extensively Drug-Resistant (XDR) Mycobacterium tuberculosis in Malaysia Provides Insights into the Genetic Basis of Its Biology and Drug Resistance.
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associated with fluoroquinolone resistance
Genomic Analysis of Mycobacterium tuberculosis Isolates and Construction of a Beijing Lineage Reference Genome.
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The G88C mutation in gyrA was found in TCDC4 and TCDC10.
Molecular characterization of pre-extensive drug resistant Mycobacterium tuberculosis in Northeast Brazil.
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MycoVarP: Mycobacterium Variant and Drug Resistance Prediction Pipeline for Whole-Genome Sequence Data Analysis.
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Genomic analysis of Mycobacterium tuberculosis variant bovis strains isolated from bovine in the state of Mato Grosso, Brazil.
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associated with quinolone resistance
Analysis of drug resistance among difficult-to-treat tuberculosis patients in Ghana identifies several pre-XDR TB cases.
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Clinical utility of target-based next-generation sequencing for drug-resistant TB.
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Mutations in gyrA were identified as a key determinant of fluoroquinolone resistance.
Detection of second-line drug resistance in Mycobacterium tuberculosis using oligonucleotide microarrays.
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Primary multidrug-resistant Mycobacterium tuberculosis in 2 regions, Eastern Siberia, Russian Federation.
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Fluoroquinolones, gyrA Not performed
Characterization of multi-drug resistant Mycobacterium tuberculosis from immigrants residing in the USA using Ion Torrent full-gene sequencing.
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Case 1
Wild-Type and Non-Wild-Type Mycobacterium tuberculosis MIC Distributions for the Novel Fluoroquinolone Antofloxacin Compared with Those for Ofloxacin, Levofloxacin, and Moxifloxacin.
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This mutation does not confer resistance and was excluded from the analysis.
Multi- and Extensively Drug Resistant Mycobacterium tuberculosis in South Africa: a Molecular Analysis of Historical Isolates.
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Genome sequence analysis of multidrug-resistant Mycobacterium tuberculosis from Malaysia.
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associated with fluoroquinolone resistance
Molecular mechanisms of underlying genetic factors and associated mutations for drug resistance in Mycobacterium tuberculosis.
Review
Translating drug resistant tuberculosis treatment guidelines to reality in war-torn Kandahar, Afghanistan: A retrospective cohort study.
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Mutations in gyrA were identified in 7 (24.1%) of patients.
Genomic Analysis of Multidrug-Resistant Mycobacterium tuberculosis Strains From Patients in Kazakhstan.
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Mutations found in all eight MDR-TB isolates.
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