ResLit - Antimicrobial Resistance Gene & Mutation Database

two-component system sensor histidine kinase

Protein ChangeS329L

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: constitutive activation of vraSR and upregulation of the genes involved in cell wall synthesis
Resistance To: vancomycin
Organisms: Staphylococcus aureus
Papers: 2

Paper Information2

Complete Reconstitution of the Vancomycin-Intermediate Staphylococcus aureus Phenotype of Strain Mu50 in Vancomycin-Susceptible S. aureus.

Research Article

Protein Change: S329L
Organisms: Staphylococcus aureus
Confers Resistance To: vancomycin
Effect on Function: constitutive activation of vraSR and upregulation of the genes involved in cell wall synthesis
Validation Method: mutant construction and MIC testing
Source Database: Reslit

Genome Sequence of a Highly Virulent pvl-positive Vancomycin-intermediate-resistant Staphylococcus aureus Sequence Type 30.

Research Article

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