Browse AMR Mutations
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
Overview
Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes clinical isolates with alterations in GyrA and ParC proteins.
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mutations in gyrA are associated with fluoroquinolone resistance
Fluoroquinolone resistance linked to GyrA, GyrB, and ParC mutations in Salmonella enterica typhimurium isolates in humans.
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Ciprofloxacin-resistant Salmonella enterica Typhimurium and Choleraesuis from pigs to humans, Taiwan.
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Suboptimal clinical response to ciprofloxacin in patients with enteric fever due to Salmonella spp. with reduced fluoroquinolone susceptibility: a case series.
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Five isolates had this mutation.
Fluoroquinolone resistance in Salmonella enterica serotype Choleraesuis, Taiwan, 2000-2003.
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Cephalosporin and ciprofloxacin resistance in Salmonella, Taiwan.
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Mutations in gyrA and parC contribute to ciprofloxacin resistance
Characterization of isolates of Salmonella enterica serovar typhimurium displaying high-level fluoroquinolone resistance in Japan.
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Clonal emergence of extended-spectrum beta-lactamase (CTX-M-2)-producing Salmonella enterica serovar Virchow isolates with reduced susceptibilities to ciprofloxacin among poultry and humans in Belgium and France (2000 to 2003).
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Single mutation in gyrA gene associated with reduced ciprofloxacin susceptibility.
Fluoroquinolone-resistant Salmonella sp. in carcasses.
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Impact of resistance selection and mutant growth fitness on the relative efficacies of streptomycin and levofloxacin for plague therapy.
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Mutations in gyrA were associated with reduced susceptibility to levofloxacin.
International spread of multidrug-resistant Salmonella Schwarzengrund in food products.
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Single base substitution in gyrA gene at codon 83 (Ser→Phe) and 87 (Asp→Asn)
Analysis of ciprofloxacin-resistant Salmonella strains from swine, chicken, and their carcasses in Taiwan and detection of parC resistance mutations by a mismatch amplification mutation assay PCR.
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Genetic diversity of Salmonella enteric serovar typhi and paratyphi in Shenzhen, China from 2002 through 2007.
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Multiple substitutions observed, including Ser83→Phe, Ser83→Pro, Ser83→Tyr, Asp87→Gly, and Asp87→Asn.
Azithromycin and ciprofloxacin resistance in Salmonella bloodstream infections in Cambodian adults.
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Mutations in gyrA were associated with decreased ciprofloxacin susceptibility.
GyrA ser83 and ParC trp106 Mutations in Salmonella enterica Serovar Typhi Isolated from Typhoid Fever Patients in Tertiary Care Hospital.
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Molecular Surveillance Identifies Multiple Transmissions of Typhoid in West Africa.
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The clinical and microbiological characteristics of enteric fever in Cambodia, 2008-2015.
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Emerging carbapenem-resistant Klebsiella pneumoniae sequence type 16 causing multiple outbreaks in a tertiary hospital in southern Vietnam.
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Mutations in gyrA contribute to fluoroquinolone resistance.
Genomic Identification of Multidrug-Resistant Salmonella Virchow Monophasic Variant Causing Human Septic Arthritis.
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A global resource for genomic predictions of antimicrobial resistance and surveillance of Salmonella Typhi at pathogenwatch.
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Distribution of fluoroquinolone resistance determinants in Carbapenem-resistant Klebsiella pneumoniae clinical isolates associated with bloodstream infections in China.
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Genotypic Diversity of Ciprofloxacin Nonsusceptibility and Its Relationship with Minimum Inhibitory Concentrations in Nontyphoidal Salmonella Clinical Isolates in Taiwan.
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Detected in 53.8% of isolates
The Evolution of Fluoroquinolone Resistance in Salmonella under Exposure to Sub-Inhibitory Concentration of Enrofloxacin.
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mutations in QRDR region
Mutational Diversity in the Quinolone Resistance-Determining Regions of Type-II Topoisomerases of Salmonella Serovars.
Review
Common mutation in S. Typhi and other Salmonella serovars.
Mutations in gyrA are common in quinolone-resistant Salmonella isolates.
Correlation between Phenotypic and In Silico Detection of Antimicrobial Resistance in Salmonella enterica in Canada Using Staramr.
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Antimicrobial Resistance and Virulence Characteristics of Klebsiella pneumoniae Isolates in Kenya by Whole-Genome Sequencing.
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Detection of antimicrobial resistance in Glaesserella parasuis in South China using whole-genome sequencing.
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Molecular epidemiology of Salmonella Enteritidis in humans and animals in Spain.
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Antimicrobial Resistance and Genomic Characterization of Salmonella Isolated from Pigeons in China.
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Mutations in quinolone resistance-determining region
Unveiling the Genetic Diversity and Antimicrobial Resistance Profiles of Salmonella Population From 2016 to 2020 in Thai Canal Water.
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Double amino acid substitutions in both positions of GyrA (S83F, D87N) and ParC (T57S, S80I) were observed in only S. Kentucky ST198 strains.
Whole-Genome Sequencing Analysis of Drug-Resistant Salmonella Typhi in Children.
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Genomic characterisation of multidrug-resistant Salmonella enterica serovar Kentucky ST198 isolates from various sources in Algeria, North Africa.
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Mutation in the quinolone-resistance-determining region of the gyrA gene
In vitro development of resistance to five quinolones and amoxicillin-clavulanate in Streptococcus pneumoniae.
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Detection of Decreased Fluoroquinolone Susceptibility in Salmonellas and Validation of Nalidixic Acid Screening Test
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Use of a LightCycler gyrA mutation assay for rapid identification of mutations conferring decreased susceptibility to ciprofloxacin in multiresistant Salmonella enterica serotype Typhimurium DT104 isolates.
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Mutations in gyrA confer decreased susceptibility to ciprofloxacin in multiresistant Salmonella enterica serotype Typhimurium DT104 isolates.
Energy-dependent accumulation of norfloxacin and porin expression in clinical isolates of Klebsiella pneumoniae and relationship to extended-spectrum beta-lactamase production.
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Life-threatening infantile diarrhea from fluoroquinolone-resistant Salmonella enterica typhimurium with mutations in both gyrA and parC.
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Levofloxacin treatment failure in Haemophilus influenzae pneumonia.
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Increasing prevalence of quinolone resistance in human nontyphoid Salmonella enterica isolates obtained in Spain from 1981 to 2003.
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Mutations in gyrA contribute to quinolone resistance.
Molecular characterization of multidrug-resistant Proteus mirabilis isolates from retail meat products.
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Ciprofloxacin-resistant Salmonella Kentucky in travelers.
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Mutations in gyrA lead to ciprofloxacin resistance.
Antimicrobial drug resistance of Salmonella enterica serovar typhi in asia and molecular mechanism of reduced susceptibility to the fluoroquinolones.
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Double amino acid substitutions in gyrA
Repression of invasion genes and decreased invasion in a high-level fluoroquinolone-resistant Salmonella typhimurium mutant.
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Mutations in QRDR of gyrA contribute to fluoroquinolone resistance
Temporal fluctuation of multidrug resistant salmonella typhi haplotypes in the mekong river delta region of Vietnam.
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The mutation was found in the sequenced H58-E2 isolate AG3.
Comparative genomics of Klebsiella pneumoniae strains with different antibiotic resistance profiles.
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Emergence of fluoroquinolone resistance in Salmonella enterica serovar Typhi in Andaman and Nicobar Islands, India.
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Mutations in gyrA and parC were identified in fluoroquinolone-resistant S. Typhi strains.
Specific patterns of gyrA mutations determine the resistance difference to ciprofloxacin and levofloxacin in Klebsiella pneumoniae and Escherichia coli.
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Mutations in gyrA are responsible for fluoroquinolone resistance.
Antimicrobial Resistance of Salmonella enterica Serovar Typhimurium in Shanghai, China.
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Mutations in gyrA and parC genes contribute to ciprofloxacin resistance.
Genomic Serotyping, Clinical Manifestations, and Antimicrobial Resistance of Nontyphoidal Salmonella Gastroenteritis in Hospitalized Children in Ho Chi Minh City, Vietnam.
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associated with ciprofloxacin resistance
Multiple Introductions of Salmonella enterica Serovar Typhi H58 with Reduced Fluoroquinolone Susceptibility into Chile.
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Mutations in lineage II
Genomic Analysis of Antimicrobial Resistance and Resistance Plasmids in Salmonella Serovars from Poultry in Nigeria.
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Genetic Determinants of Antibiotic Resistance in Francisella.
Review
Outbreak of NDM-1-producing Klebsiella pneumoniae in the intensive care unit during the COVID-19 pandemic: Another nightmare.
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Genomic Epidemiology of Multidrug-Resistant Nontyphoidal Salmonella in Young Children Hospitalized for Gastroenteritis.
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Quinolone Resistance of Actinobacillus pleuropneumoniae Revealed through Genome and Transcriptome Analyses.
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Anti-microbial resistance of Salmonella isolates from raw meat-based dog food in Japan.
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Mutation in quinolone resistance-determining region
Genetic and in-silico approaches for investigating the mechanisms of ciprofloxacin resistance in Salmonella typhi: Mutations, extrusion, and antimicrobial resistance.
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Genomic dynamics of high-risk carbapenem-resistant klebsiella pneumoniae clones carrying hypervirulence determinants in Egyptian clinical settings.
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found in some isolates
Insights into antibiotic resistance promoted by quinolone exposure.
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Mutations in gyrA conferred resistance to ciprofloxacin (CIP).
Molecular Epidemiology and Clinical Characterization of Carbapenemase-Producing Enterobacter Species From an International Cohort.
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An exploration of unusual antimicrobial resistance phenotypes in Salmonella Typhi from Blantyre, Malawi reveals the ongoing role of IncHI1 plasmids.
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gyrA_S83F mutation associated with reduced susceptibility to fluoroquinolones
Highly drug resistant clone of Salmonella Kentucky ST198 in clinical infections and poultry in Zimbabwe.
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Retrospective analysis of antimicrobial resistance associated with bovine respiratory disease.
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Stool carriage of CTX-M/CMY-producing Salmonella enterica in a Chinese tertiary hospital in Shenzhen, China.
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Non-typhoidal Salmonella transmission reservoirs in Sub-Saharan Africa: a genomic assessment from a one health perspective.
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Comparative genomic analysis of Flavobacterium species causing columnaris disease of freshwater fish in Thailand: insights into virulence and resistance mechanisms.
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Mutations in gyrA were associated with decreased susceptibility to quinolones and fluoroquinolones.
Molecular Characteristics of Epidemiologically Successful Salmonella Enteritidis in Poland.
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Mutations in Topoisomerase Genes of Fluoroquinolone-Resistant Salmonellae in Hong Kong.
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Salmonella enterica serotype Choleraesuis: epidemiology, pathogenesis, clinical disease, and treatment.
Review
Mutations in gyrA contribute to fluoroquinolone resistance
Single-nucleotide polymorphism mutation spectra and resistance to quinolones in Salmonella enterica serovar Enteritidis with a mutator phenotype.
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Mutations in the quinolone resistance-determining region (QRDR) of gyrA were associated with resistance to quinolones.
Fluoroquinolone-resistant Salmonella Paratyphi A.
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Multidrug resistance in Salmonella enterica serotype Typhimurium from humans in France (1993 to 2003).
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Ciprofloxacin-resistant Salmonella enterica serotype Typhimurium, China.
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A case of multidrug-resistant Salmonella enterica serovar Typhi treated with a bench to bedside approach.
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Salmonella enterica serovar Typhi with CTX-M beta-lactamase, Germany.
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Mutation in gyrA leads to reduced susceptibility to ciprofloxacin
Fitness costs and stability of a high-level ciprofloxacin resistance phenotype in Salmonella enterica serotype enteritidis: reduced infectivity associated with decreased expression of Salmonella pathogenicity island 1 genes.
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Antimicrobial resistance, class 1 integrons, and genomic island 1 in Salmonella isolates from Vietnam.
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Salmonella typhi in the democratic republic of the congo: fluoroquinolone decreased susceptibility on the rise.
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Mutations at codons 83 and 87 in the gyrA gene were associated with decreased ciprofloxacin susceptibility (DCS).
Abstracts from the 3rd International Genomic Medicine Conference (3rd IGMC 2015) : Jeddah, Kingdom of Saudi Arabia. 30 November - 3 December 2015.
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Wild type gyrA genes were found in 4/18 phenotypic FQ resistant NTS isolates
Genomic analysis of Salmonella enterica serotype Paratyphi A during an outbreak in Cambodia, 2013-2015.
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Mutation associated with decreased susceptibility to ciprofloxacin.
Molecular and Clinical Epidemiology of Salmonella Paratyphi A Isolated from Patients with Bacteremia in Nepal.
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All isolates had a same single mutation C248T in gyrA encoding Ser83Phe; however, no mutation was found in gyrB, parC, and parE.
Characterization of antimicrobial resistance markers & their stability in Salmonella enterica serovar Typhi.
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Mutations in gyrA were identified as the mechanism for nalidixic acid resistance.
The impact of therapeutic-dose induced intestinal enrofloxacin concentrations in healthy pigs on fecal Escherichia coli populations.
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Salmonella Typhi acquires diverse plasmids from other Enterobacteriaceae to develop cephalosporin resistance.
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Molecular Characterization and Survive Abilities of Salmonella Heidelberg Strains of Poultry Origin in Brazil.
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Mutation in gyrA subunit A
Multiple introductions of multidrug-resistant typhoid associated with acute infection and asymptomatic carriage, Kenya.
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detected in 33 genomes (23% of H58)
The molecular basis of extensively drug-resistant Salmonella Typhi isolates from pediatric septicemia patients.
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Emergence of mcr-1-Harboring Salmonella enterica Serovar Sinstorf Type ST155 Isolated From Patients With Diarrhea in Jiangsu, China.
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Mutations in gyrA contribute to ciprofloxacin resistance.
Genomic Analysis of Ciprofloxacin-Resistant Salmonella enterica Serovar Kentucky ST198 From Spanish Hospitals.
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Common mutation in ciprofloxacin-resistant isolates
Extensive Drug-Resistant Salmonella enterica Isolated From Poultry and Humans: Prevalence and Molecular Determinants Behind the Co-resistance to Ciprofloxacin and Tigecycline.
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Mutations in gyrA gene were detected at codon S83 or D87 or both in 89.66% of XDR Salmonella.
Genomics of human and chicken Salmonella isolates in Senegal: Broilers as a source of antimicrobial resistance and potentially invasive nontyphoidal salmonellosis infections.
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Whole Genome Sequence Analysis of Multidrug Resistant Escherichia coli and Klebsiella pneumoniae Strains in Kuwait.
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Characterisation of Salmonella Enteritidis ST11 and ST1925 Associated with Human Intestinal and Extra-Intestinal Infections in Singapore.
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Salmonella Typhi Haplotype 58 biofilm formation and genetic variation in isolates from typhoid fever patients with gallstones in an endemic setting in Kenya.
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Point mutation in the Quinolone Resistance-Determining Region (QRDR)
Genomic perspective on the bacillus causing paratyphoid B fever.
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Mutations in quinolone resistance-determining regions of gyrA and gyrB
Molecular Epidemiology and In-Depth Characterization of Klebsiella pneumoniae Clinical Isolates from Armenia.
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De novo acquisition of antibiotic resistance in six species of bacteria.
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Prevalence and characterization of ciprofloxacin-resistant Salmonella enterica spp. isolated from food animals during 2010-2023 in South Korea.
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Phenotypic and Genomic Assessment of Antimicrobial Resistance and Virulence Factors Determinants in Salmonella Heidelberg Isolated from Broiler Chickens.
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Genomic analyses reveal presence of extensively drug-resistant Salmonella enterica serovars isolated from clinical samples in Guizhou province, China, 2019-2023.
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Mutations in quinolone resistance-determining regions (QRDRs)
Brief antibiotic use drives human gut bacteria towards low-cost resistance.
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Mutations in gyrA were found to occur de novo within the gut and persist long after antibiotic exposure, with no measurable fitness cost.
Comprehensive analysis of extensive drug-resistant Salmonella Typhi in Gujarat region, India: genomic findings and prospective alternative therapy.
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mutation in QRDR region
Plasmid-driven clonal expansion of multidrug-resistant monophasic Salmonella Typhimurium in a Global Food Trade Hub.
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Genomic evolution of Salmonella Dublin in cattle and humans in the United States.
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Paratyphoid fever and the genomics of Salmonella enterica serovar Paratyphi A in Taiwan.
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Detected in 64 isolates.
A contemporary genomic snapshot of Salmonella Paratyphi A in Pakistan.
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Multiple point mutations in gyrA were identified, contributing to ciprofloxacin resistance.
Combating Klebsiella pneumoniae: from antimicrobial resistance mechanisms to phage-based combination therapies.
Review
Mutations in gyrA contribute to quinolone resistance.
Trends in serotype distribution and antimicrobial susceptibility in Salmonella enterica isolates from humans in Belgium, 2009 to 2013.
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A high-resolution genomic analysis of multidrug-resistant hospital outbreaks of Klebsiella pneumoniae.
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A novel technique for detecting antibiotic-resistant typhoid from rapid diagnostic tests.
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Mutations in gyrA are associated with fluoroquinolone resistance in S. Typhi.
Phylogeographical analysis of the dominant multidrug-resistant H58 clade of Salmonella Typhi identifies inter- and intracontinental transmission events.
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Structure based in silico analysis of quinolone resistance in clinical isolates of Salmonella Typhi from India.
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Mutations in the QRDR of gyrA are responsible for quinolone resistance in S. Typhi.
Mutations in DNA Gyrase alter the characteristics of the binding pocket resulting in the loss of crucial molecular interactions and consequently decrease the binding affinity of fluoroquinolones with the target protein.
Antimicrobial susceptibility of travel-related Salmonella enterica serovar Typhi isolates detected in Switzerland (2002-2013) and molecular characterization of quinolone resistant isolates.
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Next generation genome sequencing reveals phylogenetic clades with different level of virulence among Salmonella Typhimurium clinical human isolates in Hong Kong.
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Increasing prevalence of ciprofloxacin-resistant food-borne Salmonella strains harboring multiple PMQR elements but not target gene mutations.
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Single or double mutations in gyrA and/or parC
Alterations in the Quinolone Resistance-Determining Regions and Fluoroquinolone Resistance in Clinical Isolates and Laboratory-Derived Mutants of Mycoplasma bovis: Not All Genotypes May Be Equal.
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Use of whole-genome sequencing to trace, control and characterize the regional expansion of extended-spectrum β-lactamase producing ST15 Klebsiella pneumoniae.
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Emergence and Diversity of Salmonella enterica Serovar Indiana Isolates with Concurrent Resistance to Ciprofloxacin and Cefotaxime from Patients and Food-Producing Animals in China.
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Mycoplasma bovis: Mechanisms of Resistance and Trends in Antimicrobial Susceptibility.
Review
Mutations in gyrA are associated with fluoroquinolone resistance.
Endemic fluoroquinolone-resistant Salmonellaenterica serovar Kentucky ST198 in northern India.
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Mutation associated with ciprofloxacin resistance
S. Enteritidis and S. Typhimurium Harboring SPI-1 and SPI-2 Are the Predominant Serotypes Associated With Human Salmonellosis in Saudi Arabia.
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A systematic review of antimicrobial resistance of typhoidal Salmonella in India.
Review
Establishing Antimicrobial Resistance Surveillance & Research Network in India: Journey so far.
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Detected in Salmonella isolates
Analysis of isolates from Bangladesh highlights multiple ways to carry resistance genes in Salmonella Typhi.
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Mutations in gyrA are associated with ciprofloxacin resistance.
Characterization and whole genome sequencing of closely related multidrug-resistant Salmonella enterica serovar Heidelberg isolates from imported poultry meat in the Netherlands.
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associated with ciprofloxacin and nalidixic acid resistance
Genomic Features of High-Priority Salmonella enterica Serovars Circulating in the Food Production Chain, Brazil, 2000-2016.
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Expansion of Salmonella Typhi clonal lineages with ampicillin resistance and reduced ciprofloxacin susceptibility in Eastern China.
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Informal genomic surveillance of regional distribution of Salmonella Typhi genotypes and antimicrobial resistance via returning travellers.
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Mutations in the quinolone resistance determining region (QRDR) of gyrA and parC are associated with reduced susceptibility to fluoroquinolones.
Persistent circulation of a fluoroquinolone-resistant Salmonella enterica Typhi clone in the Indian subcontinent.
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Mutations in gyrA and parC contribute to fluoroquinolone resistance.
Diversity of Serotype, Genotype, and Antibiotic Susceptibility of Salmonella Prevalent in Pickled Ready-to-Eat Meat.
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Mutations in GyrA contribute to quinolone resistance.
Mutations in GyrA are associated with fluoroquinolone resistance.
Ciprofloxacin-Resistant Salmonella enterica Serovar Kentucky ST198 in Broiler Chicken Supply Chain and Patients, China, 2010-2016.
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Mutations in gyrA contribute to nalidixic acid resistance.
Pathogenomics and Evolutionary Epidemiology of Multi-Drug Resistant Clinical Klebsiella pneumoniae Isolated from Pretoria, South Africa.
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International lineages of Salmonella enterica serovars isolated from chicken farms, Wakiso District, Uganda.
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Genomic surveillance detects Salmonella enterica serovar Paratyphi A harbouring blaCTX-M-15 from a traveller returning from Bangladesh.
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mutation in gyrA conferring resistance to quinolones
Molecular characterization of metallo-β-lactamase- producing carbapenem-resistant Enterobacter cloacae complex isolated in Heilongjiang Province of China.
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Genomic Characterization of a Plasmid-Free and Highly Drug-Resistant Salmonella enterica Serovar Indiana Isolate in China.
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Phenotypic and genetic characterization of antimicrobial resistance in Salmonella enterica serovar Choleraesuis isolates from humans and animals in Spain from 2006 to 2021.
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Polymyxin Resistance in Salmonella: Exploring Mutations and Genetic Determinants of Non-Human Isolates.
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Genetic Diversity of Salmonella enterica subsp. enterica Serovar Enteritidis from Human and Non-Human Sources in Portugal.
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Genomic analysis of Salmonella isolated from canal water in Bangkok, Thailand.
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Persistent Colonization of Ciprofloxacin-Resistant and Extended-Spectrum β-Lactamase (ESBL)-Producing Salmonella enterica Serovar Kentucky ST198 in a Patient with Inflammatory Bowel Disease.
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Predominance of multidrug-resistant Salmonella Typhi genotype 4.3.1 with low-level ciprofloxacin resistance in Zanzibar.
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A Set of Multiresistant Isolates of Mycoplasma bovis Subtype ST-1 with a Variable Susceptibility to Quinolones Are Also Circulating in Spain.
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A novel variant in Salmonella genomic island 1 of multidrug-resistant Salmonella enterica serovar Kentucky ST198.
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Mutations in the quinolone resistance-determining region (QRDR) of gyrA.
Antimicrobial resistance and population genomics of emerging multidrug-resistant Salmonella 4,[5],12:i:- in Guangdong, China.
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Serovar and sequence type distribution and phenotypic and genotypic antimicrobial resistance of Salmonella originating from pet animals in Chongqing, China.
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Comparative analysis of the complete genome of KPC-2-producing Klebsiella pneumoniae Kp13 reveals remarkable genome plasticity and a wide repertoire of virulence and resistance mechanisms.
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double substitution
Lack of efflux mediated quinolone resistance in Salmonella enterica serovars Typhi and Paratyphi A.
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associated with resistance
Emergence of clinical Salmonella enterica serovar Typhimurium isolates with concurrent resistance to ciprofloxacin, ceftriaxone, and azithromycin.
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Molecular analysis of ciprofloxacin resistance mechanisms in Malaysian ESBL-producing Klebsiella pneumoniae isolates and development of mismatch amplification mutation assays (MAMA) for rapid detection of gyrA and parC mutations.
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Induction of resistant mutants of Salmonella enterica serotype Typhi under ciprofloxacin selective pressure.
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Single mutation in gyrA gene at S83
Antimicrobial resistance in Salmonella enterica Serovar Typhi isolates from Bangladesh, Indonesia, Taiwan, and Vietnam.
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Mutations in gyrA and parC contribute to quinolone resistance.
Rapid Emergence and Clonal Dissemination of CTX-M-15-Producing Salmonella enterica Serotype Virchow, South Korea.
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Single substitution within the quinolone resistance-determining region of GyrA at codon 83 (Ser→Phe)
Fluoroquinolone resistance in Salmonella: insights by whole-genome sequencing.
Review
chromosomal mutations in gyrA contribute to fluoroquinolone resistance
A systematic review of antimicrobial resistance in Salmonella enterica serovar Typhi, the etiological agent of typhoid.
Review
Salmonella enterica Serovar Typhi in Bangladesh: Exploration of Genomic Diversity and Antimicrobial Resistance.
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Mutations in gyrA are associated with ciprofloxacin resistance.
The phylogeography and incidence of multi-drug resistant typhoid fever in sub-Saharan Africa.
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Mutations in gyrA confer reduced susceptibility to fluoroquinolones.
Identifying the mechanism underlying treatment failure for Salmonella Paratyphi A infection using next-generation sequencing - a case report.
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Mutations in gyrA contribute to fluoroquinolone resistance
The first Canadian pediatric case of extensively drug-resistant Salmonella Typhi originating from an outbreak in Pakistan and its implication for empiric antimicrobial choices.
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chromosomal mutation
Salmonella Typhi From Blood Cultures in the Democratic Republic of the Congo: A 10-Year Surveillance.
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gyrA S83F substitution resulted in higher MIC values.
Molecular and Physiological Characterization of Fluoroquinolone-Highly Resistant Salmonella Enteritidis Strains.
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Mutations in gyrA are associated with fluoroquinolone resistance.
Genomic Investigation of the Emergence of Invasive Multidrug-Resistant Salmonella enterica Serovar Dublin in Humans and Animals in Canada.
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Mutations in gyrA lead to fluoroquinolone resistance.
Global phylogenomics of multidrug-resistant Salmonella enterica serotype Kentucky ST198.
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Ceftriaxone-resistant Salmonella enterica serotype Typhi in a pregnant traveller returning from Karachi, Pakistan to Denmark, 2019.
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Chromosomally and Plasmid-Located mcr in Salmonella from Animals and Food Products in China.
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Molecular Detection of gyrA Mutation in Clinical Strains of Klebsiella pneumoniae.
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Multiple amino acid substitutions at codons 83 and 87 were identified.
Molecular characterization of extended-spectrum cephalosporin and fluoroquinolone resistance genes in Salmonella and Shigella isolated from clinical specimens in Thailand.
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Pervasive Selection for Clinically Relevant Resistance and Media Adaptive Mutations at Very Low Antibiotic Concentrations.
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The genomic characterization of Salmonella Paratyphi A from an outbreak of enteric fever in Vadodara, India.
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74.35% of isolates had S83F substitution, 25.6% had S83Y substitution
Genomic analyses of drug-resistant Salmonella enterica serovar Heidelberg strains isolated from meat and related sources between 2013 and 2017 in the south region of Brazil.
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Whole-Genome Analysis of Antimicrobial-Resistant Salmonella enterica Isolated from Duck Carcasses in Hanoi, Vietnam.
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Editorial: Mobile genetic elements as dissemination drivers of multidrug-resistant Gram-negative bacteria
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Ceftriaxone resistant Salmonella enterica serovar Paratyphi A identified in a case of enteric fever: first case report from Pakistan.
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Mutation in the quinolone resistance determining region
A Nationwide Genomic Study of Clinical Klebsiella pneumoniae Carrying bla(OXA-232) and rmtF in China.
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Genomic Characterization and Genetic Profiles of Salmonella Gallinarum Strains Isolated from Layers with Fowl Typhoid in Colombia.
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Isolation, susceptibility profiles and genomic analysis of a colistin-resistant Salmonella enterica serovar Kentucky strain COL-R.
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mutation in gyrA gene
Multidrug-resistant non-typhoidal Salmonella of public health significance recovered from migratory birds in Bangladesh.
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Serotypes, Antimicrobial Resistance Profiles, and Virulence Factors of Salmonella Isolates in Chinese Edible Frogs (Hoplobatrachus rugulosus) Collected from Wet Markets in Hong Kong.
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Mutation in gyrA gene leading to fluoroquinolone resistance
Poultry production as the main reservoir of ciprofloxacin- and tigecycline-resistant extended-spectrum β-lactamase (ESBL)-producing Salmonella enterica serovar Kentucky ST198.2-2 causing human infections in China.
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Mutations in gyrA confer resistance to fluoroquinolones.
Genomic Characterization of Salmonella Isangi: A Global Perspective of a Rare Serovar.
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Salmonella isangi gyrA conferring resistance to fluoroquinolones; CARD accession: CARD:3007751
Genomic analysis and antimicrobial activity of β-lactam/β-lactamase inhibitors and other agents against KPC-producing Klebsiella pneumoniae clinical isolates from Brazilian hospitals.
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Global distribution of antimicrobial resistance in Salmonella Typhi
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associated with ciprofloxacin non-susceptibility
Phenotypic and genotypic antimicrobial resistance correlation and plasmid characterization in Salmonella spp. isolates from Italy reveal high heterogeneity among serovars.
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A One Health approach based on genomics for enhancing the Salmonella enterica surveillance in Colombia.
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Contribution of different mechanisms to the resistance to fluoroquinolones in clinical isolates of Salmonella enterica.
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Characterization of class 1 integrons and antibiotic resistance genes in multidrug-resistant Salmonella enterica isolates from foodstuff and related sources.
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Emergence of Resistance Mutations in Salmonella enterica Serovar Typhi Against Fluoroquinolones.
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Mutations in gyrA contribute to fluoroquinolone resistance
Molecular epidemiology of fluoroquinolone resistant Salmonella in Africa: A systematic review and meta-analysis.
Review
Most common mutation in quinolone resistant Salmonella.
Resistome Analysis of a Carbapenemase (OXA-48)-Producing and Colistin-Resistant Klebsiella pneumoniae Strain.
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Nonsynonymous mutations in the gyrA gene
Overview of the development of quinolone resistance in Salmonella species in China, 2005-2016.
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mutations in QRDRs of gyrA are associated with reduced CIP susceptibility
Laboratory and molecular surveillance of paediatric typhoidal Salmonella in Nepal: Antimicrobial resistance and implications for vaccine policy.
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Mutations in the QRDR of gyrA contribute to fluoroquinolone resistance.
Bacteriological profile and antimicrobial susceptibility patterns of urine culture isolates from patients in Ndjamena, Chad.
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Resistome of carbapenem- and colistin-resistant Klebsiella pneumoniae clinical isolates.
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mutations in gyrA
Phylogenetic Analysis Indicates a Longer Term Presence of the Globally Distributed H58 Haplotype of Salmonella Typhi in Southern India.
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HIV Drugs Inhibit Transfer of Plasmids Carrying Extended-Spectrum β-Lactamase and Carbapenemase Genes.
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Mutation in gyrA confers resistance to nalidixic acid.
Population structure and antimicrobial resistance patterns of Salmonella Typhi isolates in urban Dhaka, Bangladesh from 2004 to 2016.
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Importation of Extensively Drug-Resistant Salmonella enterica Serovar Typhi Cases in Ontario, Canada.
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Mutation in gyrA leads to reduced susceptibility to fluoroquinolones
Isolation of Drug-Resistant Gallibacterium anatis from Calves with Unresponsive Bronchopneumonia, Belgium.
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Molecular epidemiology of Salmonella Infantis in Europe: insights into the success of the bacterial host and its parasitic pESI-like megaplasmid.
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Systematic Evaluation of Whole Genome Sequence-Based Predictions of Salmonella Serotype and Antimicrobial Resistance.
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Non-synonymous mutation at amino acid 83 in gyrA correlates with quinolone resistance.
Discovery of seven novel mutations of gyrB, parC and parE in Salmonella Typhi and Paratyphi strains from Jiangsu Province of China.
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Mutations in gyrA contribute to quinolone resistance
Genomic profiling of antimicrobial resistance genes in clinical isolates of Salmonella Typhi from patients infected with Typhoid fever in India.
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Antimicrobial Resistance in Salmonella enterica Serovar Paratyphi B Variant Java in Poultry from Europe and Latin America.
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Mycoplasma bovis in Spanish Cattle Herds: Two Groups of Multiresistant Isolates Predominate, with One Remaining Susceptible to Fluoroquinolones.
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Frequency of Antimicrobial Resistance Genes in Salmonella From Brazil by in silico Whole-Genome Sequencing Analysis: An Overview of the Last Four Decades.
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Mutations in gyrA contribute to fluoroquinolone resistance.
Whole genome sequencing analyses revealed that Salmonella enterica serovar Dublin strains from Brazil belonged to two predominant clades.
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Detection of Antimicrobial Resistance Mechanisms in Third-Generation Cephalosporin and Ciprofloxacin Resistant Salmonella Isolates from Livestock Meat and Human Diarrhea Patients
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Spread of Carbapenem-Resistant Klebsiella pneumoniae Clinical Isolates Producing NDM-Type Metallo-β-Lactamase in Myanmar.
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Clustered Regularly Interspaced Short Palindromic Repeats Genotyping of Multidrug-Resistant Salmonella Heidelberg Strains Isolated From the Poultry Production Chain Across Brazil.
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Genomic and Evolutionary Analysis of Salmonella enterica Serovar Kentucky Sequence Type 198 Isolated From Livestock In East Africa.
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Mutations in gyrA and parC confer resistance to ciprofloxacin.
Dynamics of Antimicrobial Resistance and Genomic Epidemiology of Multidrug-Resistant Salmonella enterica Serovar Indiana ST17 from 2006 to 2017 in China.
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Mutations in gyrA contribute to fluoroquinolone resistance.
Antimicrobial resistance genes, virulence markers and prophage sequences in Salmonella enterica serovar Enteritidis isolated in Tunisia using whole genome sequencing.
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Mutations in gyrA gene confer resistance to nalidixic acid and pefloxacin.
The Resistance Mechanism of Mycoplasma bovis From Yaks in Tibet to Fluoroquinolones and Aminoglycosides.
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Molecular characterization of circulating Salmonella Typhi strains in an urban informal settlement in Kenya.
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Antimicrobial resistance of Salmonella Indiana from retail chickens in China and emergence of an mcr-1-harboring isolate with concurrent resistance to ciprofloxacin, cefotaxime, and colistin.
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A retrospective investigation of the population structure and geospatial distribution of Salmonella Paratyphi A in Kathmandu, Nepal.
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Mutations in gyrA were associated with reduced susceptibility to fluoroquinolones.
A multicenter genomic epidemiological investigation in Brazil, Chile, and Mexico reveals the diversity and persistence of Salmonella populations in surface waters.
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The origins of haplotype 58 (H58) Salmonella enterica serovar Typhi.
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Mutations in the quinolone resistance determining region (QRDR) of gyrA are associated with decreased fluoroquinolone susceptibility.
Investigation of gyrA and parC mutations and the prevalence of plasmid-mediated quinolone resistance genes in Klebsiella pneumoniae clinical isolates.
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Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms.
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Mutations in gyrA are associated with resistance to fluoroquinolones.
Bacterial Genomics for National Antimicrobial Resistance Surveillance in Cambodia.
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Comparative in vitro activity of Delafloxacin and other antimicrobials against isolates from patients with acute bacterial skin, skin-structure infection and osteomyelitis.
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Genome-Based Analysis of Genetic Diversity, Antimicrobial Susceptibility, and Virulence Gene Distribution in Salmonella Pullorum Isolates from Poultry in China.
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High prevalence of acquired quinolone-resistance genes among Enterobacteriaceae from Saudi Arabia with CTX-M-15 β-lactamase.
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Under development. Phenotype should be used with caution.
Salmonella typhimurium gyrA mutations associated with fluoroquinolone resistance.
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Comparative studies of mutations in animal isolates and experimental in vitro- and in vivo-selected mutants of Salmonella spp. suggest a counterselection of highly fluoroquinolone-resistant strains in the field.
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Quinolone-resistant gyrase mutants demonstrate decreased susceptibility to triclosan.
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Escherichia coli gyrA with mutation conferring resistance to triclosan; CARD accession: CARD:3004335
Salmonella enterica gyrA with mutation conferring resistance to triclosan; CARD accession: CARD:3004334
Prevalence of gyrA Mutations in Nalidixic Acid-Resistant Strains of Salmonella Enteritidis Isolated from Humans, Food, Chickens, and the Farm Environment in Brazil.
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Salmonella enterica gyrA conferring resistance to fluoroquinolones; CARD accession: CARD:3003926
gyrA mutations associated with fluoroquinolone resistance in eight species of Enterobacteriaceae.
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gyrA
Mechanisms of quinolone resistance in Escherichia coli and Salmonella: recent developments.
Review
gyrA
Prevalence, virulence, antimicrobial resistance, and molecular characterization of fluoroquinolone resistance of Vibrio parahaemolyticus from different types of food samples in China.
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gyrA
A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A.
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Mutations in gyrA are associated with decreased fluoroquinolone susceptibility.
Ciprofloxacin-resistant Salmonella enterica Serotype Typhi, United States, 1999-2008.
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Phylogenomics and antimicrobial resistance of Salmonella Typhi and Paratyphi A, B and C in England, 2016-2019.
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Mutations in gyrA contribute to fluoroquinolone resistance.
Unraveling Antimicrobial Resistance Dynamics in Mycoplasma gallisepticum: Insights Into Antibiotic and Disinfectant Interactions.
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Mutations in gyrA lead to fluoroquinolone resistance.
Diversity of Sequence Types and Impact of Fitness Cost among Carbapenem-Resistant Acinetobacter baumannii Isolates from Tripoli, Libya.
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Nalidixic acid-a good marker of fluoroquinolone resistance mechanisms in Escherichia coli.
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Comparative genomic analysis of Acinetobacter baumannii clinical isolates reveals extensive genomic variation and diverse antibiotic resistance determinants.
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Outbreak of Ciprofloxacin-Resistant Shigella sonnei Associated with Travel to Vietnam, Republic of Korea.
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Mutation GyrA(S83L)
Determining antimicrobial susceptibility in Salmonella enterica serovar Typhimurium through whole genome sequencing: a comparison against multiple phenotypic susceptibility testing methods.
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A Comprehensive Account of Escherichia coli Sequence Type 131 in Wastewater Reveals an Abundance of Fluoroquinolone-Resistant Clade A Strains.
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Mutations in gyrA were identified in clade A strains, contributing to fluoroquinolone resistance.
Multidrug-resistant Escherichia coli causing canine pyometra and urinary tract infections are genetically related but distinct from those causing prostatic abscesses.
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Variant O89 O-Antigen of E. coli Is Associated With Group 1 Capsule Loci and Multidrug Resistance.
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Mutations in gyrA contribute to quinolone resistance.
Genotypic antimicrobial resistance assays for use on E. coli isolates and stool specimens.
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Omadacycline Is Highly Active In Vitro against Mycoplasma genitalium.
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Genetic characterization of ESBL-producing and ciprofloxacin-resistant Escherichia coli from Belgian broilers and pigs.
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Mutations in QRDR of gyrA and parC were found in all ciproR-E. coli.
Molecular epidemiology and pathogenomics of extended-spectrum beta-lactamase producing- Escherichia coli and - Klebsiella pneumoniae isolates from bulk tank milk in Tennessee, USA.
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Mutations in gyrA contribute to fluoroquinolone resistance.
Antimicrobial Resistance in Swine Fecal Specimens Across Different Farm Management Systems.
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Whole Genome Sequencing and Characterization of Multidrug-Resistant (MDR) Bacterial Strains Isolated From a Norwegian University Campus Pond.
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found in E. coli strains
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