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© 2026 ResLit. Data sourced from PubMed literature analysis.

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Browse Mutations mmpR5S68G

transcriptional repressor of the MmpS5-MmpL5 efflux pump

Protein ChangeS68G

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: disables its transcriptional repressor function
Resistance To: Bedaquiline
Organisms: Mycobacterium tuberculosis, Mycobacterium bovis
Papers: 1

Paper Information1

1

Resistance against Membrane-Inserting MmpL3 Inhibitor through Upregulation of MmpL5 in Mycobacterium tuberculosis.

PMID 32958714 · 2020

Mutations in mmpR5 result in upregulation of mmpL5, leading to resistance.

Mutation Information

Protein Change: S68G
Organisms: Mycobacterium tuberculosis, Mycobacterium bovis
Confers Resistance To

ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

Bedaquiline

Effect on Function

disables its transcriptional repressor function

Source Database

Reslit

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© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research