ResLit - Antimicrobial Resistance Gene & Mutation Database

GenegraS

two-component sensor histidine kinase

Protein ChangeF38G

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: The F38G mutation reduces the ability of GraS to sense and respond to cationic antimicrobial peptides, leading to decreased resistance to polymyxin B.
Resistance To: Polymyxin b
Organisms: Staphylococcus aureus
Papers: 1

Paper Information1

Role of the Staphylococcus aureus Extracellular Loop of GraS in Resistance to Distinct Human Defense Peptides in PMN and Invasive Cardiovascular infections.

PMID 34227840 · 2021

Mutation in the extracellular loop of GraS affects resistance to polymyxin B and other cationic peptides.

Mutation Information

graS: p.F38G

Protein Change: F38G
Organisms: Staphylococcus aureus
Confers Resistance To

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Mutation Information