ResLit - Antimicrobial Resistance Gene & Mutation Database

GenepirA

siderophore-drug receptor

Protein ChangeY636*

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: premature termination of the protein translation and alters the structure of the β-barrel
Resistance To: Cefiderocol
Organisms: Pseudomonas aeruginosa
Papers: 1

Paper Information1

Novel PiuC, PirA, and PiuA mutations leading to in vivo cefiderocol resistance progression in IMP-16- and KPC-2-producing Pseudomonas aeruginosa from a leukemic patient.

PMID 39873515 · 2025

Nonsense mutation in PirA

Mutation Information

pirA: p.Y636*

Protein Change: Y636*
Organisms: Pseudomonas aeruginosa
Confers Resistance To: Cefiderocol

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Mutation Information