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© 2026 ResLit. Data sourced from PubMed literature analysis.

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Browse Mutations rpoBR548H

GenerpoB

Protein ChangeR548H

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: increased MIC for rifampin
Resistance To: Rifampin
Organisms: Mycobacterium tuberculosis, Mycobacterium smegmatis
Papers: 1

Paper Information1

1

Molecular analysis of codon 548 in the rpoB gene involved in Mycobacterium tuberculosis resistance to rifampin.

PMID 25534743 · 2015

The mutation was found in a clinical isolate and validated by constructing recombinant strains.

Mutation Information

Protein Change: R548H
Organisms: Mycobacterium tuberculosis, Mycobacterium smegmatis
Confers Resistance To

ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

Rifampin

Effect on Function

increased MIC for rifampin

Source Database

Reslit

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© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research